1.
Synlett
; 32(6): 601-604, 2021.
Artigo
em Inglês
| MEDLINE
| ID: mdl-34366570
RESUMO
A highly efficient synthesis of a ß-vinylserine synthetic equivalent is reported that exploits the stereodirecting effect of the N-toluenesulfonamide in an anti-diastereoselective (8.5:1) vinyl Grignard addition to an analogue of Garner's aldehyde. Both aryl and alkyl Grignards are shown to give increased anti-selectivity compared with N-Boc Garner's aldehyde.