RESUMO
Intravenous injection of nonselective antagonists of opioid receptors (OR) naltrexone (5 mg/kg) and naloxone methiodide (5 mg/kg), selective δ1-OR antagonist BNTX (0.7 mg/kg), selective δ2-OR blocker naltriben (0.3 mg/kg), selective κ-OR antagonist norbinaltorphimine (2 mg/kg), and selective blocker of ORL1 opioid receptors JTC-801 (0.1 mg/kg) produced no effect on reperfusion injury to the heart in rats narcotized with α-chloralose. In contrast, selective µ-OR antagonist CTAP (1 mg/kg) limited the infarct size, although this effect was not observed at a lower CTAP concentration of 0.1 mg/kg. Probably, the myocardial infarct size-limiting effect of CTAP was associated with activation of the non-opioid receptors. It was hypothesized that endogenous OR agonists did not affect heart resistance to reperfusion injury in unadapted rats.
Assuntos
Traumatismo por Reperfusão Miocárdica/metabolismo , Receptores Opioides/fisiologia , Analgésicos Opioides/farmacologia , Animais , Cardiotônicos/farmacologia , Resistência à Doença , Frequência Cardíaca , Masculino , Miocárdio/patologia , Antagonistas de Entorpecentes/farmacologia , Fragmentos de Peptídeos/farmacologia , Fragmentos de Peptídeos/fisiologia , Fatores de Proteção , Ratos Wistar , Somatostatina/farmacologia , Somatostatina/fisiologiaRESUMO
Intrauterine Candida albicans infection in mouse fetuses affected the type of granulomatous inflammation induced by BCG vaccine during the postnatal period. It manifested in increased formation of granulomas and variations in their cellular composition.
Assuntos
Candida albicans , Candidíase/imunologia , Granuloma/imunologia , Hepatopatias/imunologia , Fagócitos/imunologia , Tuberculose/imunologia , Animais , Vacina BCG/toxicidade , Candidíase/complicações , Modelos Animais de Doenças , Feminino , Granuloma/microbiologia , Hepatopatias/microbiologia , Camundongos , Monócitos/imunologia , Gravidez , Lesões Pré-Natais/imunologia , Lesões Pré-Natais/microbiologia , Tuberculose/complicações , Útero/microbiologiaRESUMO
Genetically determined peculiarities of the reaction of the mononuclear phagocyte system to BCG vaccine manifested in CBA and C57Bl/6 mice by differences in the number and size of granulomas and time course of changes in the cellular composition of granulomas, peripheral blood, and bone marrow.
Assuntos
Leucócitos Mononucleares/fisiologia , Fagócitos/fisiologia , Fagocitose , Animais , Células da Medula Óssea/metabolismo , Modelos Animais de Doenças , Granulócitos/metabolismo , Granuloma/metabolismo , Leucócitos Mononucleares/microbiologia , Macrófagos/metabolismo , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Camundongos Endogâmicos CBA , Modelos Biológicos , Neurônios/metabolismo , Fagócitos/microbiologia , Fenótipo , Especificidade da Espécie , Tuberculose/patologiaRESUMO
Morphological study of the effects of semisynthetic derivatives of betulin (betulonic acid and [3-oxo-20(29)-lupene-28-oyl]-3-aminopropionic acid) on the liver of CBA/Lac mice with transplanted RLS lymphoma was studied in the control and after cytostatic polychemotherapy. The number of small focal necroses decreased, while the counts of hepatocytes in a state of slight hyaline droplet degeneration increased. Morphometry of the main elements of liver parenchyma showed that alanine amide derivative of betulonic acid decreases the severity of necrotic and degenerative changes in the liver parenchyma, induced by cytostatic polychemotherapy. Betulonic acid exhibited no appreciable hepatoprotective effect under these conditions.