RESUMO
A concise and efficient approach to the synthesis of structurally diverse 6,8a-dihydropyrido[2,3-d]pyrimidine derivatives has been accomplished by a three-component reaction involving sulfonyl acetonitrile, an aromatic aldehyde, and 6-aminouracil. The method involves the domino Knoevenagel condensation/Michael addition/cyclization cascade in the presence of triethylamine in refluxing ethanol.
Assuntos
Pirimidinas/química , Pirimidinas/síntese química , Aldeídos/química , Catálise , Técnicas de Química Sintética , Ciclização , Estereoisomerismo , Uracila/análogos & derivados , Uracila/químicaRESUMO
A copper catalyzed one-pot, three component reaction between barbituric acid, aldehydes and terminal alkynes has been developed for the construction of pyrano[2,3-d]pyrimidines via a tandem conjugative alkynylation/6-endo cyclization pattern. Screening of barbituric acid derived organic acceptors in conjugative alkynylation reaction and the synthetic applicability of conjugative addition products under one-pot conditions were documented for the first time.
RESUMO
A novel method for the construction of ß,ß-disubstituted indanones has been developed via tandem Nakamura addition-hydroarylation-decarboxylation process. Indium(III) triflate was demonstrated as a versatile multitasking catalyst, which catalyzes three different chemical transformations under one-pot conditions.
Assuntos
Indanos/química , Índio/química , Alcinos/química , Catálise , Ciclização , DescarboxilaçãoRESUMO
A highly efficient, catalyst-free group-assisted purification chemical protocol for the construction of pyrimidine containing poly-functionalized pyrroles from a four-component domino reaction of acyclic-1,3-dicarbonyls or electron deficient alkynes, aromatic amines, barbituric acid and arylglyoxal hydrates under mild reaction conditions has been developed. The prominent features of the present protocol are environmentally benign, mild reaction conditions, atom economy, no column chromatography separation, easy isolation of products and excellent yields.
Assuntos
Técnicas de Química Sintética/métodos , Pirimidinas/química , Pirimidinas/síntese química , Pirróis/química , Pirróis/síntese química , Cromatografia , Química Verde , Modelos Moleculares , Pirimidinas/isolamento & purificação , Pirróis/isolamento & purificaçãoRESUMO
The 3,3'-bioxindole derivatives were constructed in a single step via an efficient Rh(2)(OAc)(4) catalyzed reaction of diazoacetamides with isatins. This novel method provides an alternative pathway towards 3-hydroxy-3,3'-bioxindoles in good yield (up to 78%) with high diastereoselectivity (up to 95 : 5).
Assuntos
Acetamidas/química , Indóis/química , Isatina/química , Ródio/química , Compostos Azo/química , Catálise , Cristalografia por Raios X , Indóis/síntese química , Modelos Moleculares , Oxindóis , EstereoisomerismoRESUMO
In(OTf)(3) is reported as the first catalyst having the ability to selectively catalyse both Markovnikov and anti-Markovnikov hydrothiolation of terminal alkynes under identical reaction conditions depending upon the nature of the thiol employed.
Assuntos
Alcinos/química , Índio/química , Compostos de Sulfidrila/química , Catálise , Especificidade por SubstratoRESUMO
A microwave-promoted aza-Diels-Alder reaction between 6-[2-(dimethylamino)vinyl]-1,3-dimethyluracil and aldimines has been developed for the construction of dihydropyrido[4,3-d]pyrimidines. Urea is effectively employed as an environmentally benign source of ammonia in the absence of any catalyst or solvent. The key step in the reaction is in situ generation and trapping of the reactive aldimine formed from urea and aldehyde by the diene system of the uracil. The reaction is clean, and excellent yields are obtained in a matter of a few minutes.
Assuntos
Pirimidinas/síntese química , Uracila/análogos & derivados , Uracila/química , Compostos de Vinila/química , Aldeídos/química , Ciclização , Química Verde , Espectroscopia de Ressonância Magnética , Espectrometria de Massas , Micro-Ondas , Estrutura Molecular , Bases de Schiff/química , Solventes , Estereoisomerismo , Ureia/químicaRESUMO
The first direct intermolecular hydroamination/hydroalkylation of terminal alkynes catalyzed by In(OTf)(3) under one-pot conditions leading to the formation of conjugated ketimines in good yields is described.
Assuntos
Alcinos/química , Índio/química , Alquilação , Aminação , Catálise , Cristalografia por Raios X , Conformação MolecularRESUMO
Condensation products obtained from the treatment of uracil amidine with preformed or in situ generated suitably substituted olefins unexpectedly undergo intramolecular cyclisation during silica gel chromatography to generate pyrido[2,3-d]pyrimidines. Various reaction conditions are studied and the altered nature of the uracil amidine molecule is further explored by reacting it with different suitably substituted alkenes.
Assuntos
Nucleosídeos de Pirimidina/síntese química , Ribonucleosídeos/síntese química , Uracila/análogos & derivados , Uracila/química , Amidinas/química , Cromatografia em Gel , Nucleosídeos de Pirimidina/química , Ribonucleosídeos/químicaRESUMO
Iodine catalyzes the pseudo four-component reaction of an aldehyde, a urea or thiourea, and cyclic 1,3-dicarbonyl compounds under microwave irradiation in a solvent-free condition to yield various σ symmetric spiro heterobicyclic rings in excellent yields.
Assuntos
Compostos Bicíclicos Heterocíclicos com Pontes/química , Compostos Bicíclicos Heterocíclicos com Pontes/síntese química , Química Verde/métodos , Iodo/química , Compostos de Espiro/química , Compostos de Espiro/síntese química , Catálise , Micro-Ondas , Solventes/química , Estereoisomerismo , Especificidade por SubstratoRESUMO
A new approach to synthesize optically active ß-amino-α-hydroxyl acid derivatives via chiral Brønsted acid-Rh(2)(OAc)(4) cocatalyzed three-component reactions of diazo acetates with alcohols and imines is reported. A matched reaction system was identified to give the products in moderate diastereoselectivity and good enantioselectivity. Application of this methodology is demonstrated in the efficient synthesis of a taxol side chain and (-)-epi-cytoxazone.
Assuntos
Compostos Organometálicos/química , Oxazóis/química , Oxazóis/síntese química , Paclitaxel/química , Paclitaxel/síntese química , Ácidos/química , Catálise , Estereoisomerismo , Especificidade por SubstratoRESUMO
An environmentally friendly and highly efficient procedure for the preparation of quinolines and fused polycyclic quinolines has been developed by a simple Friedlander annulation reaction of 2-aminoaryl ketone with carbonyl compounds in presence of zinc triflate under microwave irradiation and solvent-free conditions. The reaction also proceeds effectively when In(OTf)(3) was used in lieu of Zn(OTf)(2) as the catalyst. The catalyst can be recovered after the reaction and reused efficiently in subsequent runs.
Assuntos
Química Inorgânica/métodos , Mesilatos/farmacologia , Quinolinas/síntese química , Catálise/efeitos dos fármacos , Catálise/efeitos da radiação , Ciclização/efeitos dos fármacos , Ciclização/efeitos da radiação , Eficiência , Reutilização de Equipamento , Espectroscopia de Ressonância Magnética , Mesilatos/química , Micro-Ondas , Modelos Biológicos , Quinolinas/químicaRESUMO
The synthesis of novel fused heterocycles is based on reactions proceeding by the mechanism of the tert-amino effect, which generalizes cyclization of certain derivatives of 3-methyl-1-phenyl-2-pyrazolin-5-ones. Using this strategy a variety of fused heterocycles is obtained by the Knoevenagel condensation of 5-tert-amino-3-methyl-1-phenylpyrazolone-4-carboxal-dehyde 3 with active methylene compounds such as malononitrile and cyanoacetamide followed by cyclisation using anhydrous zinc chloride.
RESUMO
Various novel pyrano [2,3-d]pyrimidines 5 and furopyrano [2,3-d]pyrimidines 7 were synthesized in 80-99% yields via a multicomponent domino Knoevenagel/hetero-Diels-Alder reaction of 1,3-dimethyl barbituric acid with an aromatic aldehyde and ethyl vinyl ether/2,3-dihydrofuran in presence of 1 mol% of indium(III) chloride. The reaction also proceeds in aqueous media without using any catalyst, but the yield is comparatively less (65-70%).
RESUMO
Electron rich 6-[(dimethylamino)methylene]amino uracil 1, undergoes [4+2] cycloaddition reactions with various in situ generated glyoxylate imine and imine oxides 6 to provide novel pyrimido[4,5-d]pyrimidine derivatives of biological significance, after elimination of dimethylamine from the (1:1) cycloadducts and oxidative aromatisation. This procedure provides a convenient method for the direct synthesis of pyrimido[4,5-d]pyrimidines in excellent yields when carried out in the solid state and under microwave irradiations.
Assuntos
Pirimidinas/síntese química , Ciclização , Micro-Ondas , Estrutura Molecular , Pirimidinas/química , Pirimidinas/efeitos da radiação , Estereoisomerismo , Relação Estrutura-AtividadeRESUMO
Novel 1H-pyrimido [4,5-c][1,2]diazepines 3 & 4 and pyrazolo [3,4-d]pyrimidines 6 were regioselectively synthesised by the reaction of 1,3-dimethyl-6-hydrazinouracils 1 with various alpha,beta-unsaturated compounds 2 and alpha-ketoalkynes 8 in excellent yields.
RESUMO
A lipase enzyme, suspended in organic media along with organic azides and irradiated under microwaves, enhances the reaction rate over thermal heating and affords the corresponding amines in high yields. The present biocatalytic method employing lipase is a significant development with remarkable regio- and chemoselectivity under microwave irradiation in organic media with excellent yields for the reduction of azide functionality.