A nested high-resolution unstructured grid 3-D ocean-sea ice-ice shelf setup for numerical investigations of the Petermann ice shelf and fjord.

Three-dimensional numerical simulation of circulation in fjords hosting marine-terminating ice shelves is challenging because of the complexity of processes involved in such environments. This often requires a comprehensive model setup. The following elements are needed: bathymetry (usually unknown beneath the glacier tongue), ice shelf draft (impacting water column thickness), oceanographic state (including tidal elevation, salinity, temperature and velocity of the water masses), sea ice and atmospheric forcing. Moreover, a high spatial resolution is needed, at least locally, which may be augmented with a coarser and computationally cheaper (nested) model that provides sufficiently realistic conditions at the boundaries. Here, we describe procedures to systematically create such a setup that uses the Finite Volume Community Ocean Model (FVCOM) for the Petermann Fjord, Northwest Greenland. The first simulations are validated against temperature and salinity observations from the Petermann Fjord in September 2019. We provide•Complete bathymetry, ice-draft and water column thickness datasets of the Petermann Fjord, with an improved representation of the topography underneath the glacier tongue.•Boundary conditions for ocean, atmosphere and sea ice derived from a suite of high-resolution regional models that can be used to initialize and run the regional ocean model with realistic geophysical settings.

Quality of life and treatment satisfaction observed among Indians with diabetes foot ulcers undergoing ayurvedic adjunct therapy.

The purpose of the study was to assess the health-related quality of life and treatment satisfaction of diabetes patients (n = 36) with foot ulcers undergoing insulin and ayurvedic adjunct therapy. Retrospective hospital based cross-sectional design considered patients with diabetes foot ulcers undergoing 4-week treatment with insulin and ayurvedic combinatorial therapy. The Audit of Diabetes Dependent Quality of Life Questionnaire and Diabetes Treatment Satisfaction Questionnaire were completed for the assessment. The mean duration of diabetes among participants was 9.32 ± 5.3 years. Assessment of Diabetes Treatment Satisfaction Questionnaire (total treatment satisfaction) score was found to be 26.0139 ± 5.20369, and Audit of Diabetes Dependent Quality of Life Questionnaire (average weighted impact) score was -3.0819 ± 1.83003. Relationship with diabetes complications showed that Audit of Diabetes Dependent Quality of Life Questionnaire score (P = .383) had no relationship, but Diabetes Treatment Satisfaction Questionnaire score (P = .039) showed significance. Integrated approaches for diabetes foot ulcer management with insulin and ayurvedic management have a favorable impact on patient-perceived quality of life.

Formulation and evaluation of herbal antioxidant face cream of Nardostachys jatamansi collected from Indian Himalayan region

Objective:To prepare and evaluate a herbal antioxidant face cream which is made by the ethanol extract of Nardostachys jatamansi (Valerianceae). Methods: Antioxidant activity of ethanol extract was assessed by previously reported 2, 2-Diphenyl-1-picrylhydrazyl method. By discovering different types of formulations, such as oil in water, we were able to create several face creams respectively classified from F1 to F6, by incorporating different concentrations of stearic acid and acetyl alcohol. The evaluation of all formulations (F1 to F6) has been done by the analysis of different parameters like pH, viscosity, spread ability and stability. Results: An ethanol fraction analyzed from a sample of Nardostachys jatamansi showed a significant antioxidant activity with an IC50 value of 58.39 μg/mL while for ascorbic acid the IC50 value was 46.68 μg/mL. Among the six formulations (F1-F6) F5 and F6 showed good spread ability, good consistency, homogeneity, appearance, pH;there is no proof of a separation phase and ease of removal. Also the formulations F5 and F6 showed no redness or edema or erythema and irritation during irritancy studies. Conclusions:These formulations can be safely used on the skin. Hence, the study suggests that the composition of extract and the base of the cream F5 and F6 are more stable and safe, but it may produce synergistic action.