Occlusion Heightened by Metal Crown Cementation is Aggressive for Periodontal Tissues.

PURPOSE: To investigate the effect of experimental traumatic occlusion (ETO) induced by metal crowns on alveolar bone loss. MATERIALS AND METHODS: Metal crowns were custom-made for the lower first molars with occlusal discrepancy of 0.4 and 0.7 mm from the maximum intercuspation. Thirty-six animals were randomly divided into three groups (n = 12 animals per group): 0.4-mm hyperocclusion group, 0.7-mm hyperocclusion group and the sham group (no metal crown). Twenty-eight days after crown cementation, the animals were euthanized and gingival tissue was collected to assess cytokine levels of IL-17, IL-6, and TNF-α using enzyme-linked immunosorbent assay (ELISA). Mandibles were stained with 1% methylene blue and alveolar bone levels were quantified. Western blotting was used to quantify the expression of receptor activator of nuclear factor κ B (RANK), and its ligand (RANKL), secreted osteoclastogenic factor of activated T cells (SOFAT) and TNF-α-converting enzyme (TACE). Also, mandibles were histologically processed and stained with hematoxylin and eosin, from which the presence of osteoclast-like cells, multinucleated cells containing ≥3 nuclei was counted at 100× magnification. The data were analyzed using one-way ANOVA and Tukey tests. RESULTS: Experimental occlusal trauma for 28 consecutive days significantly increased alveolar bone loss and multinucleated cell counts (p < 0.05). RANK, RANKL, SOFAT, TACE, IL-6, and TNF-α were significantly higher in gingival tissues of ETO groups (p < 0.05). IL-17 titers were unchanged among the groups (p > 0.05). CONCLUSION: Experimental traumatic occlusion activates and sustains bone resorption pathways in the periodontium inducing alveolar bone resorption. As the intensity of occlusal trauma increased, alternative osteoclastic pathways were activated, such as TACE and SOFAT.

Relação entre doenças periodontais e cardiovasculares em cardiopatas assistidos na Univali - Itajaí/SC / Relationship between periodontal disease and cardiovascular diseases in cardiopathy patients attended at Univali -Itajaí (SC)

As doenças cardiovasculares resultam de etiologia complexa e de fatores de risco como a hipertensão, tabagismo, diabetes e comprometimentos genéticos. Da mesma forma, a doença periodontal, que é um estado inflamatório nos tecidos de sustentação dos dentes, apresenta os mesmos fatores de risco e afeta a integridade endotelial, o metabolismo das proteínas plasmáticas, a coagulação e a função das plaquetas. Por esse motivo, o objetivo deste trabalho foi verificar a relação entre doenças periodontais e cardiovasculares em pacientes cardiopatas assistidos na Universidade do Vale do Itajaí - SC (Univali). Foi realizado anamnese para verificar a patologia cardíaca de cada paciente, seus hábitos nocivos, suas patologias associadas, a idade e o sexo. O exame periodontal foi realizado nos pacientes que se enquadravam nos critérios de inclusão deste trabalho, sendo classificados quanto á extensão e á severidade da doença periodontal e á extensão do sangramento gengival. Os autores concluíram que a condição oral, especialmente a relativa á doença periodontal, parece ser um significativo fator de risco para doenças cardiovasculares, e que fatores sistêmicos podem estar envolvidos de forma simultânea na origem das duas doenças