[Acute intermittent porphyria as a problem in differential diagnosis]. / Akutna intermitentna porfirija kao deferencijalnodijagnosticki problem.

In this study the authors have stressed the multidisciplinary approach regarding the etiology of psychiatric disorders. This approach provides not only the quantitative but also the qualitative increase within the essence of psychic life and psychiatric disorders pointing out the integrity of biological, psychological and social in a human being. Many somatic diseases are followed by the psychiatric and neurological symptoms. One of these diseases is the acute intermittent porphyria (AIP) that is manifested with a wide spectrum of clinical manifestations and it is called "the great imitator". The AIP attacks are characterized by abdominal pains, neurologic and psychiatric disorders. The most important is to diagnose the disease at the onset. If not, many severe complications may occur, even the lethal outcome is possible. This case report has shown the significance of the above mentioned statements.

[Association of manifestations of chronic post-traumatic stress disorders and disseminated demyelinating disease of the central nervous system]. / Udruzena pojava posttraumatskog stresnog poremecaja hronicnog toka i diseminovanog demijelinizacijskog oboljenja centralnog nervnog sistema.

The study included 7 patients who were with clinically, laboratory, neurophysiologically and neuroradiologically confirmed associated occurrence of posttraumatic stress disorder of chronic course and disseminated demyelinating disease of the central nervous system. All the examinees were extendedly exposed to war stress, so it could be directly designated as the cause of posttraumatic stress syndrome and indirectly denoted as the trigger of immune disorder that brought to disseminated demyelination of the central nervous system.

[The neurohumoral status in depression]. / Neurohumoralni status depresija.

In 66 patients with endogenous depression (34 males and 32 females) the concentrations of biogene amine metabolites (vanilmandelic acid (VMA), 5-hydroxyindole acetic acid (5-HIIA), adrenaline and noradrenaline) were examined in 24-hrs urine and hormone in the serum: iodothyronine (T-3), thyroxine (T-4), thyroglobulin (Tg), thyroid-stimulating hormone (TSH), adrenocorticotropic hormone (ACTH), cortisol, prolactin and growth hormones. The examination was performed prior to the initiation of antidepressant therapy and 30 days after its application. The biogene amine metabolites were in reference values before initiation of the therapy, although values of 5-HIIA in women and were closer to the lower limit. Thirty days after the initiation of the antidepressant therapy the statistically significant difference was found at the level of p < 0.05 for adrenalin in men and for VMA and 5-HIIA in women. The hormone values before initiation of the therapy showed increased values of growth hormone, cortisol in men and of thyroglobulin, growth hormone and cortisol in women. At the end of the antidepressant therapy the statistically significant difference was found at the level of p < 0.05 for thyroglobulin and TSH in men and for thyroglobulin, growth hormone and cortisol in women. By comparing the results obtained before and after the antidepressant therapy, the statistically significant difference was found at the level of p < 0.05 for Tg in men and for Tg, T-3, prolactin and growth hormone compared to the women. It has been concluded that in patients with endogenous depression the important role in pathogenesis of the disease have some neurobiogenic disorders.

[Masked depression]. / Maskirane depresije.

The study comprised 25 patients with masked depression and 30 patients with endogenous depression. According to the general characteristics both groups were homogenous and accordingly, comparable. Together with clinical evaluation of depressive syndrome, psychological management was applied. Rorschach test, Thematic Apperception Test and Minnesota Multiphasic Personality Inventory were used in the study. In the clinical picture of masked depressions somatovegetative disorders dominated and depressive behavior in endogenous depression. The frequence of suicid does not differ between patients with masked and endogenous depression.