RESUMO
The airway response to inhaled antigen was measured in asthmatic patients at 5, 10 ad 20 minutes following bronchial challenges. The over-all frequency of positive responses in the 26 individual challenges was 27%. There were no significant differences between the 5-, 10- or 20-minute responses. Patients with positive responses to bronchial challenge manifested high grade skin reactivity by intradermal tests. Positive responses to bronchial challenge occurred only at 1 X 10(-3) weight/volume (w/v) concentration of inhaled antigen. Although the degree of methacholine reactivity was related to positive antigen challenge, two subjects with a positive challenge had minimal methacholine reactivity.
Assuntos
Antígenos/administração & dosagem , Asma/diagnóstico , Testes de Provocação Brônquica , Adulto , Idoso , Humanos , Masculino , Pessoa de Meia-Idade , Testes CutâneosRESUMO
Bronchial reactivity to inhaled diluent and methacholine was determined for asthmatics using automated spirometry. These data were compared with challenge data from a matched group of asthmatics previously studied plethysmographically. High correlations were obtained between all indices both groups, suggesting that spirometry is adequate for the clinical characterization of the methacholine response.
Assuntos
Compostos de Metacolina/farmacologia , Adulto , Obstrução das Vias Respiratórias/tratamento farmacológico , Relação Dose-Resposta a Droga , Volume Expiratório Forçado , Humanos , Masculino , Pessoa de Meia-Idade , Pico do Fluxo Expiratório , Pletismografia , Soluções , EspirometriaRESUMO
The airway response to methacholine was measured in 27 asthmatics. Selected indices of airway response were measured at 5-, 10- and 20-minute intervals and at three concentrations of methacholine. The mean change from control was significant at all three concentrations and there were no significant differences between time intervals. High correlations were obtained between all indices of airway response to methacholine challenge.
Assuntos
Asma/tratamento farmacológico , Compostos de Metacolina/uso terapêutico , Adulto , Idoso , Relação Dose-Resposta a Droga , Humanos , Masculino , Pessoa de Meia-Idade , Fatores de TempoRESUMO
The authors have demonstrated that patients with bronchial asthma may react to diluent provocative challenge. The pattern of airway response to diluent was found to be reproducible. The data herewith presented suggest that the baseline airway obstruction in adult asthma is highly variable but the degree of baseline obstruction is not related to the response to diluent challenge.
Assuntos
Asma/diagnóstico , Bicarbonatos/administração & dosagem , Fenóis/administração & dosagem , Cloreto de Sódio/administração & dosagem , Administração Intranasal , Obstrução das Vias Respiratórias/diagnóstico , Humanos , Curvas de Fluxo-Volume Expiratório Máximo , Pico do Fluxo Expiratório , Capacidade VitalRESUMO
This study was designed to analyze the airway response to an aerosolized diluent in patients with asthma. Fifty percent of the patients responded to diluent with less than a 10% variation from baseline (non responders), but 20% of the patients responded with more than a 25% difference from baseline (responders). This study stresses the need for control data with diluent prior to bronchial challenge with a provocative agent.