Waveform Similarity Analysis Using Graph Mining for the Optimization of Sensor Positioning in Wearable Seismocardiography.

OBJECTIVE: A major concern with wearable devices aiming to measure the seismocardiogram (SCG) signal is the variability of SCG waveform with the sensor position and a lack of a standard measurement procedure. We propose a method to optimize sensor positioning based on the similarity among waveforms collected through repeated measurements. METHOD: we design a graph-theoretical model to evaluate the similarity of SCG signals and apply the proposed methodology to signals collected by sensors placed in different positions on the chest. A similarity score returns the optimal measurement position based on the repeatability of SCG waveforms. We tested the methodology on signals collected by using two wearable patches based on optical technology placed in two positions: mitral and aortic valve auscultation site (inter-position analysis). 11 healthy subjects were enrolled in this study. Moreover, we evaluated the influence of the subject's posture on waveform similarity with a view on ambulatory use (inter-posture analysis). RESULTS: the highest similarity among SCG waveforms is obtained with the sensor on the mitral valve and the subject lying down. CONCLUSIONS: our approach aims to be a step forward in the optimization of sensor positioning in the field of wearable seismocardiography. We demonstrate that the proposed algorithm is an effective method to estimate similarity among waveforms and outperforms the state-of-the-art in comparing SCG measurement sites. SIGNIFICANCE: results obtained from this study can be exploited to design more efficient protocols for SCG recording in both research studies and future clinical examinations.

A meta-learning algorithm for respiratory flow prediction from FBG-based wearables in unrestrained conditions.

The continuous monitoring of an individual's breathing can be an instrument for the assessment and enhancement of human wellness. Specific respiratory features are unique markers of the deterioration of a health condition, the onset of a disease, fatigue and stressful circumstances. The early and reliable prediction of high-risk situations can result in the implementation of appropriate intervention strategies that might be lifesaving. Hence, smart wearables for the monitoring of continuous breathing have recently been attracting the interest of many researchers and companies. However, most of the existing approaches do not provide comprehensive respiratory information. For this reason, a meta-learning algorithm based on LSTM neural networks for inferring the respiratory flow from a wearable system embedding FBG sensors and inertial units is herein proposed. Different conventional machine learning approaches were implemented as well to ultimately compare the results. The meta-learning algorithm turned out to be the most accurate in predicting respiratory flow when new subjects are considered. Furthermore, the LSTM model memory capability has been proven to be advantageous for capturing relevant aspects of the breathing pattern. The algorithms were tested under different conditions, both static and dynamic, and with more unobtrusive device configurations. The meta-learning results demonstrated that a short one-time calibration may provide subject-specific models which predict the respiratory flow with high accuracy, even when the number of sensors is reduced. Flow RMS errors on the test set ranged from 22.03 L/min, when the minimum number of sensors was considered, to 9.97 L/min for the complete setting (target flow range: 69.231 ± 21.477 L/min). The correlation coefficient r between the target and the predicted flow changed accordingly, being higher (r = 0.9) for the most comprehensive and heterogeneous wearable device configuration. Similar results were achieved even with simpler settings which included the thoracic sensors (r ranging from 0.84 to 0.88; test flow RMSE = 10.99 L/min, when exclusively using the thoracic FBGs). The further estimation of respiratory parameters, i.e., rate and volume, with low errors across different breathing behaviors and postures proved the potential of such approach. These findings lay the foundation for the implementation of reliable custom solutions and more sophisticated artificial intelligence-based algorithms for daily life health-related applications.