[Antimicrobial activity of piperacillin in vitro]. / Antimikrobnaia aktivnost' piperatsillina in vitro.

There was an increase in the resistance of clinical isolates to piperacillin as compared to that in 1987-1988. It was shown on the kinetic models that there was difference in the effect of the inhibitory and subinhibitory concentrations of the drug on microorganisms in various growth phases. No post-antibiotic action against Staphylococcus aureus and Pseudomonas aeruginosa and a slightly pronounced dose-dependent effect with respect to Escherichia coli were noted.

[Antimicrobial activity of ceftazidime and its pharmacokinetics in patients with renal failure]. / Antimikrobnaia aktivnost' tseftazidima i ego farmakokinetika u bol'nykh s pochechnoi nedostatochnost'iu.

High antimicrobial activity of ceftazidime against clinical gram-positive (except Streptococcus viridans and S. faecalis) and gram-negative strains of microorganisms was shown. It was found that the drug dosing regimens required correction in cases with impaired excretion function of the kidneys. Hemodialysis lowered 2-4 times the drug blood levels.