RESUMO
It has been determined that prostaglandins E2 and F2 alpha being exogenously inoculated during the premetastatic period to mice with metastatic Lewis lung carcinoma in equal degree activate neurocytes of supraoptic and paraventricular hypothalamus nuclei, playing the important role in secretion of peptidergic hypophysial adrenal gland complex, but they exert unequal influence on pituitary body, adrenal cortex and thyroid apparatus. F2 alpha stimulates the pituitary body corticotrophic function, secretory function of spongiocytes and thyrocytes, identifies the thyroxin and triiodothyronine utilization, E2, on the contrary, does not influence these indices or reduces them. Obviously, the mentioned above differences between E2 and F2 alpha may be explained by their different influences on antimetastatic resistance.
Assuntos
Dinoprosta/farmacologia , Dinoprostona/farmacologia , Sistema Hipotálamo-Hipofisário/efeitos dos fármacos , Neoplasias Pulmonares/fisiopatologia , Metástase Neoplásica , Sistema Hipófise-Suprarrenal/efeitos dos fármacos , Glândula Tireoide/efeitos dos fármacos , Animais , Sistema Hipotálamo-Hipofisário/fisiopatologia , Neoplasias Pulmonares/imunologia , Masculino , Camundongos , Camundongos Endogâmicos C57BL , Metástase Neoplásica/imunologia , Sistema Hipófise-Suprarrenal/fisiopatologia , Glândula Tireoide/fisiopatologia , Hormônios Tireóideos/sangueRESUMO
Some magnocellular and parvocellular hypothalamic nuclei of cockerel were studied for their reactivity to testosterone-propionate (TP). It has been ascertained that injections of 1 or 5 micrograms/100 g doses of TP activate the neurocytes of preoptic periventricular and tuberal nuclei. This effect is manifested between 45th and 60th day of life and may be regarded as an early event of sexual maturation.