Volumetric wireless coils for breast MRI: A comparative analysis of metamaterial-inspired coil, Helmholtz coil, ceramic coil, and solenoid.

This study comprehensively assesses radiofrequency (RF) volumetric wireless coils utilizing artificial materials for clinical breast MRI. In particular, we evaluated the transmit efficiency, RF safety, and homogeneity of magnetic field amplitude distribution for four structures electromagnetically coupled with a whole-body birdcage coil: extremely high permittivity ceramic coil, solenoid coil, Helmholtz coil, and metamaterial-inspired coil based on periodically coupled split-loop resonators. These coils exhibit favorable attributes, including lightweight construction, compactness, cost-effectiveness, and ease of manufacturing. The results of this study demonstrated that the metamaterial-inspired coil outperforms other wireless coils considered for addressing a specific problem in terms of the set of characteristics. In particular, the metamaterial-inspired coil achieved 85% and 88% homogeneity in magnetic field amplitude distribution at 3 T and 1.5 T MRI, respectively. Also, the 1.5 T metamaterial-inspired coil demonstrated the best performance, increasing the efficiency gain of the birdcage coil by 4.93 times and improving RF safety by 2.96 times. This research explains the limitations and peculiarity of utilizing the volumetric wireless coils in 1.5 and 3 T MRI systems.

Т1 mapping of rat lungs in 19 F MRI using octafluorocyclobutane.

PURPOSE: To demonstrate the feasibility of using octafluorocyclobutane (OFCB, c-C4 F8 ) for T1 mapping of lungs in 19 F MRI. METHODS: The study was performed at 7 T in three healthy rats and three rats with pulmonary hypertension. To increase the sensitivity of 19 F MRI, a bent-shaped RF coil with periodic metal strips structure was used. The double flip angle method was used to calculate normalized transmitting RF field (B1n + ) maps and for correcting T1 maps built with the variable flip angle (VFA) method. The ultrashort TE pulse sequence was applied for acquiring MR images throughout the study. RESULTS: The dependencies of OFCB relaxation times on its partial pressure in mixtures with oxygen, air, helium, and argon were obtained. T1 of OFCB linearly depended on its partial pressure with the slope of about 0.35 ms/kPa in the case of free diffusion. RF field inhomogeneity leads to distortion of T1 maps built with the VFA method, and therefore to high standard deviation of T1 in these maps. To improve the accuracy of the T1 maps, the B1n + maps were applied for VFA correction. This contributed to a 2-3-fold decrease in the SD of T1 values in the corresponding maps compared with T1 maps calculated without the correction. Three-dimensional T1 maps were obtained, and the mean T1 in healthy rat lungs was 35 ± 10 ms, and in rat lungs with pulmonary hypertension - 41 ± 9 ms. CONCLUSION: OFCB has a spin-rotational relaxation mechanism and can be used for 19 F T1 mapping of lungs. The calculated OFCB maps captured ventilation defects induced by edema.

Improving detection of fMRI activation at 1.5 T using high permittivity ceramics.

In this work, we propose an application of high permittivity materials (HPMs) to improve functional magnetic resonance imaging (fMRI) at 1.5 T, increasing the receive (Rx) sensitivity of a commercial multi-channel head coil. To evaluate the transmit efficiency, specific absorption rate (SAR), and the signal-to-noise ratio (SNR) changes introduced by the HPMs with relative permittivity of 4500, we considered the following configurations in simulation: a whole-body birdcage coil and an Rx-only multi-channel head coil with and without the HPM blocks in the presence of a homogeneous head phantom or a human body model. Experimental studies were also performed with a phantom and with volunteers. Seven healthy volunteers enrolled in a prospective study of fMRI activation in the motor cortex with and without HPMs. fMRI data were analyzed using group-level paired T-tests between acquisitions with and without HPM blocks. Both electromagnetic simulations and experimental measurements showed ∼25% improvement in the Rx sensitivity of a commercial head coil in the areas of interest when HPM blocks were placed in close proximity. It increased the detected motor cortex fMRI activation volume by an average of 56%, thus resulting in more sensitive functional imaging at 1.5 T.

Quadrature transceive wireless coil: Design concept and application for bilateral breast MRI at 1.5 T.

PURPOSE: Development of a novel quadrature inductively driven transceive wireless coil for breast MRI at 1.5 T. METHODS: A quadrature wireless coil (HHMM-coil) design has been developed as a combination of two linearly polarized coils: a pair of 'metasolenoid' coils (MM-coil) and a pair of Helmholtz-type coils (HH-coil). The MM-coil consisted of an array of split-loop resonators. The HH-coil design included two electrically connected flat spirals. All the wireless coils were coupled to a whole-body birdcage coil. The HHMM-coil was studied and compared to the linear coils in terms of transmit and SAR efficiencies via numerical simulations. A prototype of HHMM-coil was built and tested on a 1.5 T scanner in a phantom and healthy volunteer. We also proposed an extended design of the HHMM-coil and compared its performance to a dedicated breast array. RESULTS: Numerical simulations of the HHMM-coil with a female voxel model have shown more than a 2.5-fold increase in transmit efficiency and a 1.7-fold enhancement of SAR efficiency compared to the linearly polarized coils. Phantom and in vivo imaging showed good agreement with the numerical simulations. Moreover, the HHMM-coil provided good image quality, visualizing all areas of interest similar to a multichannel breast array with a 32% reduction in signal-to-noise ratio. CONCLUSION: The proposed quadrature HHMM-coil allows the B 1 + $$ {\mathrm{B}}_1^{+} $$ -field to be significantly better focused in the region-of-interest compared to the linearly polarized coils. Thus, the HHMM-coil provides high-quality breast imaging on a 1.5 T scanner using a whole-body birdcage coil for transmit and receive.

Imaging Capabilities of the ¹H-X-Nucleus Metamaterial-Inspired Multinuclear RF-Coil.

In this paper, we present the initial experimental investigation of a two-coil receive/transmit design for small animals imaging at 7T MRI. The system uses a butterfly-type coil tuned to 300 MHz for scanning the 1H nuclei and a non-resonant loop antenna with a metamaterial-inspired resonator with the ability to tune over a wide frequency range for X-nuclei. 1H, 31P, 23Na and 13C, which are of particular interest in biomedical MRI, were selected as test nuclei in this work. Coil simulations show the two parts of the radiofrequency (RF) assembly to be decoupled and operating independently due to the orthogonality of the excited RF transverse magnetic fields. Simulations and phantom experimental imaging show sufficiently homogeneous transverse transmit RF fields and tuning capabilities for the pilot multiheteronuclear experiments.

Metamaterial inspired wireless coil for clinical breast imaging.

In this work, we propose an application of a metamaterial inspired volumetric wireless coil (WLC) based on coupled split-loop resonators for targeted breast MRI at 1.5 T. Due to strong electromagnetic coupling with the body coil, the metamaterial inspired WLC locally focuses radiofrequency (RF) magnetic flux in the target region, thus improving both transmit and receive performance of the external body coil. This leads to substantial enhancement in local transmit efficiency and improvement of RF safety. Phantom images showed a tenfold increase of signal-to-noise ratio (SNR) in the region-of-interest (ROI) and, at the same time, an almost 50-fold reduction in transmit power relative to the same body coil used alone.