[Characterization of medical and neurological care of stroke patients. An analysis of the data from the project, "Safeguarding Quality in Stroke Care," of the Regional Medical Council of Baden-Württemberg]. / Charakterisierung internistisch und neurologsich versorgter Schlaganfallpatienten. Eine Analyse der Daten des Projektes "Qualitätssicherung in der Schlaganfallversorgung" der Landesärztekammer Baden Württemberg.

BACKGROUND AND OBJECTIVE: Patients with stroke are treated in either medical or neurological units. This study investigated whether the two cohorts differ regarding their demographic composition, previous diseases, severity of the stroke and comorbidity. PATIENTS AND METHODS: Data were collected prospectively on 2890 patients with acute stroke (50.2 % males, 49.8 % females) admitted to medical or stroke units of hospitals in Baden-Württemberg. RESULTS: The mean age of patients treated on a medical ward was significantly higher (77 vs. 71 years). They also had significantly higher, age-related incidence of pre-existing disease (Ranking scale) and of previous cerebral episodes (32.9 % vs. 19.1 %). They had a higher incidence of atrial fibrillation (27.6 % vs. 20.5 %) and treated diabetes mellitus (31.5 % vs. 25.4 %) Various neurological deficits were also significantly more pronounced: abnormal awareness (42.4 % vs. 26.7 %), level of consciousness (29.3% vs. 12.8%), swallowing (20.3 % vs. 10.8 %), speaking (40.0 % vs. 31.5%) and speech (20.3% vs. 10.8 %) and transitory ischaemic attacks (21.2 % vs. 25.5 %). Rankin scale and Barthel index differed similarly. The patients treated in medical wards remained in hospital significantly longer (14.9 % vs. 13.9 %) and they had a higher death rate (10.6 % vs. 5.6 %) and were more disabled. CONCLUSION: Patients after an acute stroke treated in medical wards differ significantly from those in stroke units by being older. Previous diseases and acute neurological deficits are more common, independent of age, and they are more disabled at discharge.

Aromatic hydroxylation in nasal lavage fluid following ambient ozone exposure.

Ozone at ambient concentrations affects lung function and initiates an inflammatory response of the airways. However, the underlying mechanisms are poorly understood. In vitro studies have shown that ozone reacts with water to give reactive hydroxyl radicals capable of oxidizing a wide range of biomolecules. We conducted a study to determine if in vivo hydroxyl radical attack on human airways occurs under natural exposure to ozone. The relation of orthotyrosine to para-tyrosine as a measure of hydroxyl radical attack was analyzed in nasal lavage samples of 44 primary school children in an epidemiologic study. Repeated nasal lavages were performed between May and October 1991 both following "low" (daily half-hour maximum < 140 micrograms/m3, approximately 70 ppb) and "high" (daily half-hour maximum > 180 micrograms/m3, approximately 90 ppb) ozone exposure. Concomitantly, lung function tests were performed. On average, 11.6 (6-16) nasal lavages were performed for each of 24 study days (10 days following "low" ozone exposure and 14 days following "high" ozone exposure). Average ortho-tyrosine (median; 5-95% percentile) for each child was 0.037 mumol/L (0.016-0.064 mumol/L) and average para-tyrosine was 15.7 mumol/L (9.8-24.1 mumol/L). Ortho-tyrosine (as percentage of tyrosine) was significantly higher following days with "high" ozone exposure (0.18%) vs. days following "low" ozone exposure (0.02%; p = .0001). Ortho-tyrosine showed an inverse relationship with forced vital capacity (p = .01) but was not related to inflammation of the upper airways as assessed by cell counts of polymorphonuclear neutrophils. Hydroxyl radical attack subsequent to ambient ozone occurs in the upper airways of healthy children and is related to lung function decrements.

[How reliable is the measurement of colonic transit time using a marker technique?]. / Wie zuverlässig ist die Messung der Kolon-Transitzeit mit Hilfe der Markertechnik?

Radioopaque markers are well established tools to determine segmental and total colonic transit time. However, since no data are available on intraindividual reproducibility, in this study reproducibility was assessed in 14 health male and 12 healthy female volunteers. The mean segmental colonic transit and total colonic transit time were not significantly different for the two measurements. Colonic transit time was consistently shorter in males than in females. The menstrual phase did not show a significant influence in the latter. The intraindividual variations of the colonic transit times were acceptable with a reproducibility coefficient of 20 h.

Ambient ozone causes upper airways inflammation in children.

Ozone constitutes a major air pollutant in Western Europe. During the summer national air quality standards are frequently exceeded, which justifies concern about the health effects of ozone at ambient concentrations. We studied upper airways inflammation after ozone exposure in 44 children by repeated nasal lavages from May to October 1991. During this time period five to eight lavages were performed for each child. On 14 days following high ozone exposure (daily maximum > or = 180 micrograms/m3) 148 nasal lavages were performed, and on 10 days following low ozone exposure (daily maximum < or = 140 micrograms/m3) 106 nasal lavages were performed. A significant increase of intra-individual mean polymorphonuclear leukocytes (PMN) counts from low ozone days (median, 20.27 x 10(3)) to high ozone days (median, 27.38 x 10(3); p < 0.01) was observed. Concomitant with a decrease of ozone concentrations in the fall mean PMN counts showed a downward trend. Linear regression analysis of log-PMN counts yielded a significant effect for ozone (p = 0.017). In a subsample humoral markers of inflammation were measured for each child's highest and lowest exposure. A significant increase was observed for eosinophilic cationic protein (median, 77.39 micrograms/L on low ozone days versus 138.6 micrograms/L on high ozone days; p < 0.05). Thus we conclude that ozone at ambient concentrations initiates a reversible inflammatory response of the upper airways in normal children.