[The effectiveness of the drug Cholisal in the complex treatment of oral mucosa and periodontal diseases]. / Effektivnost' primeneniya preparata Kholisal v kompleksnom lechenii zabolevanii slizistoi obolochki polosti rta i parodonta.

PURPOSE OF THE STUDY: Evaluation of the clinical efficacy of the drug holisal¼ according to the results of domestic and foreign studies on modern methods for treatment of inflammatory diseases of the oral mucosa mouth and periodontium. MATERIALS AND METHODS: The study method was a comparative analysis of data obtained by various authors. The literature search was conducted on PubMed (www.ncbi.nlm.nih.gov), eLibrary (elibrary.ru) and ScienceDirect (www.sciencedirect.com). RESULTS: The drug Cholisal reduces the duration of treatment, allows to increase the period of remission of the disease. It also promotes pain relief and accelerated mucosal epithelialization of the mouth mucosa. CONCLUSION: Clinical studies of the drug Cholisal have shown that a wide range of its pharmacological action ensures the effectiveness of treatment of inflammatory diseases of the oral mucosa and periodontium by a combination of analgesic, antimicrobial, anti-inflammatory, and antifungal effects.

[The effectiveness of parodontax toothpaste in the complex treatment of chronic gingivitis]. / Effektivnost' primeneniya zubnoi pasty parodontax v kompleksnom lechenii khronicheskogo gingivita.

THE AIM OF THE STUDY: Was to evaluate the clinical efficacy of parodontax Comprehensive Protection (GlaxoSmithKline, London, UK) toothpaste in the complex therapy of chronic gingivitis. MATERIALS AND METHODS: The study involved 119 volunteers; group 1 (n=59, age range 18 to 32 years) and group 2 (n=60, age range 20 to 35 years) with a diagnosis of chronic gingivitis (K05.1). The criterion for inclusion in the study was sulcus bleeding index (SBI) more than 1 point. Dental examination included SBI, papillary-marginal-alveolar index (PMA), and Green-Vermillion oral hygiene index (OHI-S). After determining the indices, all patients underwent professional oral hygiene and controlled tooth cleaning. Patients in group 1 (parodontax) were prescribed parodontax Comprehensive Protection toothpaste (GlaxoSmithKline, London, UK), patients in group 2 - a toothpaste that did not contain sodium bicarbonate. Repeated clinical examinations with the determination of the SBI, PMA, OHI-S were carried out after week 2 and 4. RESULTS: After 4 weeks, SBI scores in group 1 were 63% lower than at baseline, and in group 2 - by 30%. PMA values at 4 weeks in group 1 were 58% and in group 2 30% lower, compared to baseline levels. The results of the analysis of the OHI-S index showed a statistically significant decrease in group 1 by 75%, while in group 2 by only 8% from the initial values. The difference in all index values between groups at 4 weeks of the study was statistically significant (p<0.05). CONCLUSION: The use of parodontax Comprehensive Protection Toothpaste (GlaxoSmithKline, London, UK) has been shown to reduce the clinical signs of biofilm-associated gingivitis and effectively maintain optimal oral hygiene in patients.

[Clinic and treatment of the oral candidiasis]. / Osobennosti kliniki i lecheniya patsientov s kandidozom slizistoi obolochki rta.

OBJECTIVE: The aim of the study is to clarify the stages of examination of patients with various clinical manifestations of nosological forms of candidiasis and to evaluate the effectiveness of the ongoing antifungal therapy in the complex treatment of oral candidiasis, considering all factors and background diseases. MATERIAL AND METHODS: 56 patients were examined and treated, of which 41 were women and 15 were men with a clinical course of candidiasis (acute pseudomembranous candidiasis, chronic hyperplastic candidiasis, angular candidiasis cheilitis). The patients' age is from 33 to 78 years. All patients underwent a bacterioscopic examination of plaque. All patients diagnosed with oral candidiasis were prescribed complex treatment, which included both general and local therapy. The diagnosis and treatment of the patient's main diseases (diabetes mellitus, hypoparathyroidism, diseases of the gastrointestinal tract, blood diseases, etc.) were mandatory. RESULTS: All patients taking antifungal therapy reported a significant improvement in the clinical condition of the oral mucosa. Burning sensation, pain, sensation of enlargement of the tongue, dryness in the oral cavity disappeared in the patients. After 2 weeks of drug therapy with fungicidal preparations, the patients were prescribed a second bacterioscopic examination. The results of laboratory studies showed the presence of single, non-budding Candida cells in the field of view and a minimal, diagnostically significant, degree of contamination, which corresponded to the candidacy. CONCLUSIONS: The study showed that antifungal therapy for oral mucosa candidiasis should always be pathogenetically justified and should be carried out considering the patient's underlying disease.

[The effectiveness of Sensodyne Instant effect toothpaste for dentin hypersensitivity treatment]. / Éffektivnost' primeneniia zubnoi pasty Sensodyne Mgnovennyi éffekt pri lechenii povyshennoi chuvstvitel'nosti dentina zubov.

The article presents an analysis of the clinical efficacy of Sensodyne Instant Effect toothpaste containing sodium fluoride and tin fluoride for the treatment of increased sensitivity of hard dental tissues. The study proved long-term efficiency of Sensodyne Instant Effect toothpaste designed to reduce tooth hyperesthesia. Toothpaste Sensodyne Instant Effect can be widely recommended to reduce the hypersensitivity of dentin.

[Oral cavity manifestations of gastroesophageal reflux disease].

The aim of the study was to investigate changes in the oral cavity and the gastroesophageal zone of the patients receiving rabeprazol, a proton pump inhibitor (PPI). The subjects were 88 patients with gastroesophageal reflux disease (GERD), who had changes in the oral cavity typical of this disease. The patients were divided into four groups. Group I included patients with non-erosive reflux disease; the other three groups were formed according to the degree of the severity of reflux esophagitis in accordance with Los Angeles classification of GERD: A, B, and C. The patients were administered rabeprazol as a PPI. The study found that oral cavity changes are associated with the degree of the gastroesophageal reflux. The study demonstrated high efficacy of rabeprazol in GERD patients with oral cavity changes.

[The use of lysoamidase for treating complications of caries and diseases of the periodontium and oral mucosa]. / Primenenie lizoamidazy dlia lecheniia oslozhnenii kariesa, zabolevanii parodonta i slizistoi obolochki polosti rta.

Antibacterial and proteolytic enzyme lysoamidase was used to treat periodontitis and a range of diseases of oral mucosa. The results displayed its major advantages over trypsin and allowed us to recommend it as an effective means of local treatment in the combined therapy of these disorders.