1.
Bioorg Med Chem Lett
; 19(19): 5708-11, 2009 Oct 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-19713109
RESUMO
A new series of NS3/4A protease boronic acid inhibitors is described. The compounds show good biochemical potency and cellular activity. The peptidomimetic inhibitors were evaluated against proteases from different HCV genotypes and clinically relevant NS3/4A mutants. Compound 28 displayed subnanomolar to single digit nanomolar potencies in the enzymatic assays and an EC50 of 25 nM in the replicon cell-based assay.