1.
Hemoglobin
; 46(3): 180-183, 2022 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-35603587
RESUMO
We here report a novel case of Hb Headington [ß72(E16)SerâArg, HBB: c.217A>C, p.Ser73Arg], in a 68-year-old woman with type 2 diabetes mellitus (T2DM). Glycosylated hemoglobin (Hb) was measured by capillary electrophoresis (CE). The spectrum showed abnormal peaks between the A0 and A2 peaks. DNA sequencing demonstrated a mutation on the HBB gene, which predicted a substitution of serine to arginine at position 73 in the ß-globin chain. Moreover, this amino acid substitution occurs at the same position as Hb Headington [ß72(E16)SerâArg, HBB: c.219T>A, p.Ser73Arg], which showed increased oxygen affinity.