A Bibliometric Analysis on Global Psychological and Behavioral Research Landscape on COVID-19 Pandemic.

The COVID-19 pandemic outbreak in December 2019 has spread globally. The ongoing psychological and behavioral effects of the COVID-19 pandemic, which poses a major challenge to humanity, are of concern to researchers. To understand the academic community's attention, focus and research collaboration on psychological and behavioral research during the COVID-19 pandemic, we conducted a macro analysis using a bibliometric approach. Using the topic selection strategy of TS = ("COVID-19" OR "coronavirus disease 2019" OR "SARS-CoV-2" OR "2019-nCoV") AND TS = ("behavio*") AND TS = ("psycholog*"), 2096 high-quality research articles and reviews were downloaded as data from the Web of Science core collection on 16 November 2021. Through analysis and visualization, the following conclusions are drawn in this study: (1) The popularity and importance of psychological and behavioral research under COVID-19 has increased significantly and needs further attention; (2). Related research focuses on eight hotspots, with quarantine, health care workers, the elderly, students, pregnant women, family, consumers, social media and emergency preparedness knowledge as the focus of the research object; and (3) Research collaboration is relatively high at the author, organizational and national levels. However, low-income countries need to get more attention. Furthermore, this article would help researchers make decisions for the research of psychological and behavioral issues under COVID-19 and planning for future prospects to contribute to academic development and applied methodology.

Mapping the biomedical sciences using Medical Subject Headings: a comparison between MeSH co-assignments and MeSH citation pairs.

OBJECTIVE: This study compares two maps of biomedical sciences using Medical Subject Headings (MeSH) term co-assignments versus MeSH terms of citing/cited articles and reveals similarities and differences between the two approaches. METHODS: MeSH terms assigned to 397,475 journal articles published in 2015, as well as their 4,632,992 cited references, were retrieved from Web of Science and MEDLINE databases, respectively, which formed over 7 million MeSH co-assignments and nearly 18 million direct citation pairs. We generated six network visualizations of biomedical science at three levels using Gephi software based on these MeSH co-assignments and citation pairs. RESULTS: The MeSH co-assignment map contained more nodes and edges, as MeSH co-assignments cover all medical topics discussed in articles. By contrast, the MeSH citation map contained fewer but larger nodes and wider edges, as citation links indicate connections to two similar medical topics. CONCLUSION: These two types of maps emphasize different aspects of biomedical sciences, with MeSH co-assignment maps focusing on the relationship between topics in different categories and MeSH direct citation maps providing insights into relationships between topics in the same or similar category.

Antitumor Activity of Cabazitaxel and MSC-TRAIL Derived Extracellular Vesicles in Drug-Resistant Oral Squamous Cell Carcinoma.

INTRODUCTION: TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) can induce apoptosis in a variety of cancer cells. However, drug resistance of tumor and short half-life seriously affects its clinical targeted therapy. Cabazitaxel (CTX) is a taxane drug, which can induce apoptosis or autophagy by inhibiting the phosphorylation of PI3K/Akt/mTOR and sensitive to some drug-resistant tumors. Therefore, we explored the possibility of developing a mesenchymal stem cell-derived exosomes (MSC-EXO) vector for oral squamous cell carcinoma (OSCC) to deliver CTX/TRAIL combinations. METHODS: After ultracentrifugation and dialysis, CTX/TRAIL loaded exosomes transfected MSC (MSCT)-derived exosome (EXO) (MSCT-EXO/CTX) were isolated and purified. The expression of CD63, CD9 and TRAIL was detected by BCA to confirm the origin of EXO. High-performance liquid chromatography (HPLC) was used to determine the drug loading of VPF and draw the in vitro release profile. MTT assay, flow cytometry and Western blot were used to detect the antitumor effect of MSCT-EXO/CTX in vitro. Subsequently, the antitumor effect of MSCT-EXO/CTX in vivo was verified by mouse model. RESULTS: The diameter of the membrane particles was about 60-150 nm. We have proved that the incorporation and release of CTX in MSCT-EXO can inhibit the activation of PI3K, Akt and mTOR, which is a possible synergistic mechanism of CTX. MSCT-EXO and CTX can induce the apoptosis of SCC25 tumor cells in a dose-dependent manner and exert a good synergistic effect in the proportion range of 10:1-5:1. The inherent activity of MSCT-EXO and the direct effect of MSCT-EXO/CTX on OSCC confirm that MSCT-EXO/CTX makes MSCT-EXO and CTX have an efficient synergistic effect and a highly effective pharmacological inhibition on cancer cells, as verified by the subsequent mouse model. MSCT-EXO/CTX showed the lowest relative tumor volume and the highest tumor inhibition rate (P<0.05) in vivo. CONCLUSION: An MSCT-EXO-based CTX delivery system might be an effective anticancer method.

Low-Order Webpage Layout in Online Shopping Facilitates Purchase Decisions: Evidence from Event-Related Potentials.

INTRODUCTION: In online shopping, the webpage layout plays an important part in the consumer's experience. The present study aims to investigate whether the webpage order and which order level (high order vs low order) facilitate consumers' instant purchase decisions for products. METHODS: Fourteen right-handed healthy undergraduates and graduate students participated in the experiment as paid participants. In the experiment, participants were presented with daily products in different online shopping webpages (high-order vs low-order) and reported their purchase intentions between purchase and not purchase. Meanwhile, Electroencephalogram (EEG) was recorded from the participants throughout the experiment. In the analysis process, two event-related potentials (ERP) components, P2 and late positive potential (LPP) were mainly focused to examine the cognitive mechanism underlying the purchase decisions. RESULTS: The behavioral data found that the low-order shopping webpage facilitated participants' purchase intentions compared with the high-order one. Neurophysiologically, increased P2 amplitudes and increased LPP amplitudes were revealed for the low-order webpage compared to the high-order webpage. The P2 indicates the early stage of attention engagement and discordant perception, while the LPP can be taken as a reflection of the late stage of the emotional self-control process. CONCLUSION: These results provided evidence that webpage order influenced people's purchase decisions. Low-order webpage design invoked more attention engagement and discordant perception and consumed more self-control resources than the high-order webpage design, which contributed to the higher purchase intentions.

Utilitarian or hedonic: Event-related potential evidence of purchase intention bias during online shopping festivals.

Online shopping festivals play a significant role in consumers' purchase decision and have been the focus of much research and many marketing practices. However, research has yet to explore which product categories can promote consumer purchase intention during online shopping festivals. This study carried out a neurophysiological experiment with event-related potentials (ERPs) to investigate the mechanism of participants' purchase intention for two classic product categories (utilitarian products (UP) and hedonic products (HP)) during online shopping festivals. The behavioral findings demonstrated that compared to HP, participants had a purchase intention bias towards UP. Neurocognitively, this purchase intention bias was reflected by a larger N2 component and a smaller LPC component for UP than for HP. N2 reflected attentional capture in the early cognitive stage, and LPC reflected the later stage of negative emotional perception. These findings provide a preliminary exploration of the mechanism of people's purchase decision of UP and HP during online shopping festivals, positively contributing marketing practices and future research.