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Fitoterapia ; 83(1): 161-5, 2012 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-22037567

RESUMO

A rare naturally-occurring polyprenylated isoflavanone, designated ormosinol (1), and a new isoflavonoid glycoside, named ormosinoside (2), along with 21 known compounds were isolated from the root bark of Ormosia henryi Prain. The structures of compounds 1 and 2 were determined as 5,7,2',4'-tetrahydroxyl-6,8,5'-tri-(γ,γ-dimethylallyl)isoflavanone and isoprunetin-7-O-ß-D-xylopyranosyl-(1 → 6)-ß-D-glucopyranoside on the basis of a combination of 1D-, 2D-NMR and mass spectroscopic measurements. Compound 1 showed significant anti-oxidation activity against DPPH radicals (IC(50) 28.5 µM) and cancer cell line (A549, LAC, and HepG2) growth inhibitory activity with IC(50) ranging from 4.25 to 7.09 µM, while compound 2 found to be inactive to both testing systems.


Assuntos
Antineoplásicos Fitogênicos/farmacologia , Antioxidantes/farmacologia , Fabaceae/química , Flavanonas/farmacologia , Isoflavonas/farmacologia , Antineoplásicos Fitogênicos/química , Antioxidantes/química , Compostos de Bifenilo/química , Linhagem Celular Tumoral , Flavanonas/química , Humanos , Isoflavonas/química , Estrutura Molecular , Picratos/química , Casca de Planta/química , Raízes de Plantas/química
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