scJVAE: A novel method for integrative analysis of multimodal single-cell data.

The study of cellular decision-making can be approached comprehensively using multimodal single-cell omics technology. Recent advances in multimodal single-cell technology have enabled simultaneous profiling of more than one modality from the same cell, providing more significant insights into cell characteristics. However, learning the joint representation of multimodal single-cell data is challenging due to batch effects. Here we present a novel method, scJVAE (single-cell Joint Variational AutoEncoder), for batch effect removal and joint representation of multimodal single-cell data. The scJVAE integrates and learns joint embedding of paired scRNA-seq and scATAC-seq data modalities. We evaluate and demonstrate the ability of scJVAE to remove batch effects using various datasets with paired gene expression and open chromatin. We also consider scJVAE for downstream analysis, such as lower dimensional representation, cell-type clustering, and time and memory requirement. We find scJVAE a robust and scalable method outperforming existing state-of-the-art batch effect removal and integration methods.

Multi-source domain adaptation of social media data for disaster management.

Labeled data scarcity at the time of an ongoing disaster has encouraged the researchers to use the labeled data from some previous disaster for training and transferring the knowledge to the current disaster task using Domain Adaptation (DA). However, often labeled data from more than one previous disaster may be available. As all deep learning models are data-hungry and perform better if fed with more annotated data, it is advisable to use data from multiple sources for training a Deep Convolutional Neural Network (DCNN). One of the easiest ways is to simply combine the data from multiple sources and use it for training. However, this arrangement is not that straightforward. The models trained on the combined data from various sources do not perform well on the target, mainly due to distribution discrepancies between multiple sources. This has motivated us to explore the challenging area of multi-source domain adaptation for disaster management. The aim is to learn the domain invariant features and representations across the domains and transfer more related knowledge to solve the target task with improved accuracy than single-source or combined-source domain adaptation. This study proposes a Multi-Source Domain Adaptation framework for Disaster Management (MSDA-DM) to classify disaster images posted on social media based on unsupervised DA with adversarial training. The empirical results obtained confirm that the proposed model MSDA-DM performs better than single-source DA by up to 10.83% and combined-source DA by up to 5.06% in terms of F1-score for different sets of source and target disaster domains. We also compare our model with current state-of-the-art models. The main challenge of multi-source DA is the choice of the relevant sources taken for training since, unlike single-source DA that handles only source-target distribution drift, the multi-source DA network has to address both source-target and source-source distribution drifts.

A novel reversible logic gate and its systematic approach to implement cost-efficient arithmetic logic circuits using QCA.

Quantum-dot cellular automata, is an extremely small size and a powerless nanotechnology. It is the possible alternative to current CMOS technology. Reversible QCA logic is the most important issue at present time to reduce power losses. This paper presents a novel reversible logic gate called the F-Gate. It is simplest in design and a powerful technique to implement reversible logic. A systematic approach has been used to implement a novel single layer reversible Full-Adder, Full-Subtractor and a Full Adder-Subtractor using the F-Gate. The proposed Full Adder-Subtractor has achieved significant improvements in terms of overall circuit parameters among the most previously cost-efficient designs that exploit the inevitable nano-level issues to perform arithmetic computing. The proposed designs have been authenticated and simulated using QCADesigner tool ver. 2.0.3.