Assuntos
Miocardite/etiologia , Doenças Reumáticas/complicações , Adulto , Artrite Reumatoide/complicações , Complexos Cardíacos Prematuros/etiologia , Fibrose Endomiocárdica/etiologia , Feminino , Bloqueio Cardíaco/etiologia , Humanos , Fator Reumatoide/análise , Disfunção Ventricular Esquerda/etiologiaRESUMO
Extra-cutaneous manifestations of neutrophilic dermatosis are exceptional and diverse: they consist of inflammatory infiltrates with neutrophil polymorphonuclears, without evidence of infectious agents. Localisations to the lung are the most frequently observed. A single observation of spleen involvement has been reported in a case of Sneddon-Wilkinson's disease. Herein we report the case of an aseptic splenic abscess during the course of a Sweet's syndrome.
Assuntos
Abscesso/etiologia , Esplenopatias/etiologia , Síndrome de Sweet/complicações , Adulto , Feminino , Humanos , Síndrome de Sweet/fisiopatologiaAssuntos
Síndrome da Imunodeficiência Adquirida/cirurgia , HIV-1 , Esplenectomia , Viremia/cirurgia , Adulto , Humanos , MasculinoRESUMO
Surrogate markers generally used for observation of patients infected with human immunodeficiency virus (HIV) and their plasma and cellular viral load were assayed in a series of 40 patients before initiation of zidovudine therapy. Plasma viremia was positive in 62.5% of patients and was statistically correlated with clinical stage, CD4+ T cell count, CD8+ T cell count, beta 2-microglobulin level, neopterin level, and immunoglobulin A level. Cellular viremia was positive in 95% of patients and was correlated with clinical stage, CD4+ T cell count, beta 2-microglobulin, neopterin levels, and disease progression during the following months. A discordance was found between p24 antigenemia, even after acid dissociation of immune complexes, and plasma viremia. In fact, p24 antigenemia was correlated with only biological markers of immune activation as beta 2-microglobulin and neopterin levels. The measurement of anti-p24 antibodies did not appear discriminative in our staging. Plasma viremia, like CD4+ T cell count, reflects the patient's status at the time of assessment. Cellular viremia could be more informative for the prediction of future clinical progression.
Assuntos
Infecções por HIV/imunologia , HIV-1/imunologia , Viremia/imunologia , Adulto , Biopterinas/análogos & derivados , Biopterinas/sangue , Linfócitos T CD4-Positivos/imunologia , Feminino , Anticorpos Anti-HIV/sangue , Proteína do Núcleo p24 do HIV/sangue , Proteína do Núcleo p24 do HIV/imunologia , Infecções por HIV/tratamento farmacológico , Infecções por HIV/microbiologia , HIV-1/crescimento & desenvolvimento , Humanos , Imunoglobulina A/sangue , Contagem de Leucócitos , Masculino , Pessoa de Meia-Idade , Neopterina , Prognóstico , Modelos de Riscos Proporcionais , Linfócitos T Reguladores/imunologia , Timidina Quinase/sangue , Viremia/tratamento farmacológico , Viremia/microbiologia , Zidovudina/uso terapêutico , Microglobulina beta-2/análiseRESUMO
A case of myasthenia associated with Hodgkin's disease with probable invasion of the thymus is reported. Five cases of association between lymphomatous thymoma and myasthenia (2 Hodgkin's thymomas and 3 non-Hodgkin's lymphomatous thymomas) have previously been reported. Myasthenia healed after the lymphoma was treated. This association raises pathogenic problems in the 3 cases of non-Hodgkin's thymoma where invasion of the thymus erased all its normal structure.