Active maintenance of musical and linguistic information as a function of musical experience.

Recent research suggests that linguistic and musical information are processed by shared working memory resources in non-musicians. However, it is still unclear how musical information is actively maintained by those with extensive musical experience. Some evidence suggests that those with musical experience may utilize distinct processing systems for the active maintenance of linguistic and musical information. To explore this possibility, a cross-modal interference paradigm was used in which those with and without musical experience were presented with an initial stimulus (word or chord), followed by intervening stimuli (words, chords, or silence), and then a comparison stimulus (word or chord). The participants' task was to indicate whether the comparison stimulus was the same or different from the initial stimulus. Results revealed a pattern of data that would be expected if the active maintenance of linguistic and musical information was accomplished by distinct systems in those with musical experience and a unitary system in non-musicians.

Correcting eyewitness suggestibility: does explanatory role predict resistance to correction?

Many studies have documented that exposure to post event misinformation can lead eyewitnesses to misremember witnessing events they did not see and do so with high confidence. The goal of the present study was to investigate whether reporting of suggested misinformation can be reversed following a correction, and if so, whether misinformation would be more resistant to correction when it serves an explanatory function than when it does not. In two experiments participants witnessed an event, were exposed to a blatantly false suggestion(s) and one week later received a correction followed by a test of their memory for the witnessed event. We found evidence for both the persistence of misinformation following a correction (E1) and the complete reversibility of misinformation effects following a highly salient correction (E2). Although false reporting of the misinformation doubled when it served an explanatory function relative to when it did not (E1 and E2), in both experiments we found no evidence that resistance to correction varied as a function of the misinformation's explanatory role. Our findings suggest that, with a salient correction provided by a credible source, people are capable of updating their knowledge with new information that reverses what they previously thought.

Shared Processing of Language and Music.

The present study sought to explore whether musical information is processed by the phonological loop component of the working memory model of immediate memory. Original instantiations of this model primarily focused on the processing of linguistic information. However, the model was less clear about how acoustic information lacking phonological qualities is actively processed. Although previous research has generally supported shared processing of phonological and musical information, these studies were limited as a result of a number of methodological concerns (e.g., the use of simple tones as musical stimuli). In order to further investigate this issue, an auditory interference task was employed. Specifically, participants heard an initial stimulus (musical or linguistic) followed by an intervening stimulus (musical, linguistic, or silence) and were then asked to indicate whether a final test stimulus was the same as or different from the initial stimulus. Results indicated that mismatched interference conditions (i.e., musical - linguistic; linguistic - musical) resulted in greater interference than silence conditions, with matched interference conditions producing the greatest interference. Overall, these results suggest that processing of linguistic and musical information draws on at least some of the same cognitive resources.

Spatial organization of multi-enzyme biocatalytic cascades.

Industrial biocatalysis is an economically attractive option for the production of valuable chemicals. Our repertoire of cheap building blocks and commodity target molecules is vastly enhanced by multi-enzyme biocatalytic cascades. In order to achieve suitable titers in complex novel biocatalytic schemes, spatial organization may become necessary to overcome barriers caused by slow or inhibited enzymes as well as instability of biocatalysts. A number of spatial organization strategies are currently available, which could be integrated in the design of complex cascades. These include fusion proteins, immobilization on solid supports, multi-dimensional scaffolding, and encapsulation within vessels. This review article highlights recent advances in cascade biocatalysis, discusses the role of spatial organization in reaction kinetics, and presents some of the currently employed strategies for spatial organization of multi-enzyme cascades.

Mechanisms of eyewitness suggestibility: tests of the explanatory role hypothesis.

In a recent paper, Chrobak and Zaragoza (Journal of Experimental Psychology: General, 142(3), 827-844, 2013) proposed the explanatory role hypothesis, which posits that the likelihood of developing false memories for post-event suggestions is a function of the explanatory function the suggestion serves. In support of this hypothesis, they provided evidence that participant-witnesses were especially likely to develop false memories for their forced fabrications when their fabrications helped to explain outcomes they had witnessed. In three experiments, we test the generality of the explanatory role hypothesis as a mechanism of eyewitness suggestibility by assessing whether this hypothesis can predict suggestibility errors in (a) situations where the post-event suggestions are provided by the experimenter (as opposed to fabricated by the participant), and (b) across a variety of memory measures and measures of recollective experience. In support of the explanatory role hypothesis, participants were more likely to subsequently freely report (E1) and recollect the suggestions as part of the witnessed event (E2, source test) when the post-event suggestion helped to provide a causal explanation for a witnessed outcome than when it did not serve this explanatory role. Participants were also less likely to recollect the suggestions as part of the witnessed event (on measures of subjective experience) when their explanatory strength had been reduced by the presence of an alternative explanation that could explain the same outcome (E3, source test + warning). Collectively, the results provide strong evidence that the search for explanatory coherence influences people's tendency to misremember witnessing events that were only suggested to them.

Analyzing Confabulations in Schizophrenia and Healthy Participants.

OBJECTIVES: Confabulations occur in schizophrenia and certain severe neuropsychiatric conditions, and to a lesser degree in healthy individuals. The present study used a forced confabulation paradigm to assess differences in confabulation between schizophrenia patients and healthy controls. METHODS: Schizophrenia patients (n=60) and healthy control participants (n=19) were shown a video with missing segments, asked to fill in the gaps with speculations, and tested on their memory for the story. Cognitive functions and severity of symptoms were also evaluated. RESULTS: Schizophrenia patients generated significantly more confabulations than healthy control participants and had a greater tendency to generate confabulations that were related to each other. Schizophrenic confabulations were positively associated with temporal context confusions and formal thought disorder, and negatively with delusions. CONCLUSIONS: Our findings show that the schizophrenia patients generate more confabulations than healthy controls and schizophrenic confabulations are associated with positive symptoms. (JINS, 2016, 22, 911-919).

The impact of outcome valence on the susceptibility to suggestion for post-event causal misinformation.

Recent research has demonstrated that people are especially susceptible to false memory development for suggested misinformation that fills a causal role (i.e., explains some known outcome) (Chrobak & Zaragoza, 2013). However, little is known about how factors associated with the witnessed outcome impact the likelihood of false memory development. In the present study, outcome valence (negative, positive, or neutral) was manipulated. Participants heard several short stories that contained an outcome (e.g., a counselor getting promoted) that lacked a causal explanation. Participants were subsequently exposed to suggested causal misinformation that explained that outcome (e.g., the counselor performed an impressive act the previous day) and then were tested on their memory for the original event. Results indicated that participants incorrectly reported the suggested causal information more when it explained either a positive or negative outcome as opposed to a neutral outcome. Theoretical and practical implications of these findings are discussed.

The Impact of Multifaceted Questions on Eyewitness Accuracy Following Forced Fabrication Interviews.

Lawyers will frequently use complex-question forms, such as multifaceted questions (single questions that contain both a true and a false proposition), when cross-examining witnesses, and prior research has shown that use of such questions reduces testimonial accuracy. The present study extends this research by using a forced fabrication paradigm (Chrobak & Zaragoza, 2008) to assess how multifaceted questions might affect eyewitness suggestibility after exposure to misleading post-event information. Consistent with prior studies, the use of multifaceted questions led to lower accuracy than simple questions. The novel finding was that multifaceted questions caused larger impairments in performance among fabrication participants (who had earlier been suggestively interviewed), than in control participants (who had not). We also provide preliminary evidence that the impairment caused by multifaceted questions is due to both (a) having to consider two propositions simultaneously, and (b) the shift in question focus from the fabricated event to a true event.

When forced fabrications become truth: causal explanations and false memory development.

Studies of text comprehension have amply demonstrated that when reading a story, people seek to identify the causal and motivational forces that drive the interactions of characters and link events (e.g., Zwaan, Langston, & Graesser, 1995), thereby achieving explanatory coherence. In the present study we provide the first evidence that the search for explanatory coherence also plays a role in the memory errors that result from suggestive forensic interviews. Using a forced fabrication paradigm (e.g., Chrobak & Zaragoza, 2008), we conducted 3 experiments to test the hypothesis that false memory development is a function of the explanatory role these forced fabrications served (the explanatory role hypothesis). In support of this hypothesis, participants were more likely to subsequently freely report (Experiment 1) and falsely assent to (Experiment 2) their forced fabrications when they helped to provide a causal explanation for a witnessed outcome than when they did not serve this explanatory role. Participants were also less likely to report their forced fabrications when their explanatory strength had been reduced by the presence of an alternative explanation that could explain the same outcome as their fabrication (Experiment 3). These findings extend prior research on narrative and event comprehension processes by showing that the search for explanatory coherence can continue for weeks after the witnessed event is initially perceived, such that causally relevant misinformation from subsequent interviews is, over time, incorporated into memory for the earlier witnessed event.

Inventing stories: forcing witnesses to fabricate entire fictitious events leads to freely reported false memories.

Studies of the forced fabrication effect have shown that participant witnesses are prone to developing false memories for specific items or details that they have been forced to fabricate earlier (e.g., what type of hat someone wore). Building on these earlier findings, the present study assessed whether participants would develop false memories if forced to fabricate entire fictitious events that were more complex and extended in time and involved people, locations, and actions that they had never seen. Participants vehemently resisted fabricating these events, and false memory development over the short term (1-week recognition test) was limited. However, after 8 weeks, participants freely reported their forced fabrications nearly 50% of the time and did so even when they had correctly and publicly rejected them earlier on the 1-week recognition test. This is the first evidence that participant witnesses will freely incorporate into their eyewitness accounts entire fictitious events that they have earlier been forced to fabricate.

Pyrido[2,3-d]pyrimidin-7-one inhibitors of cyclin-dependent kinases.

The identification of 8-ethyl-2-phenylamino-8H-pyrido[2, 3-d]pyrimidin-7-one (1) as an inhibitor of Cdk4 led to the initiation of a program to evaluate related pyrido[2, 3-d]pyrimidin-7-ones for inhibition of cyclin-dependent kinases (Cdks). Analysis of more than 60 analogues has identified some clear SAR trends that may be exploited in the design of more potent Cdk inhibitors. The most potent Cdk4 inhibitors reported in this study inhibit Cdk4 with IC(50) = 0.004 microM ([ATP] = 25 microM). X-ray crystallographic analysis of representative compounds bound to the related kinase, Cdk2, reveals that they occupy the ATP binding site. Modest selectivity between Cdks is exhibited by some compounds, and Cdk4-selective inhibitors block pRb(+) cells in the G(1)-phase of the cell division cycle.

Tropical spastic paraparesis on the Caribbean coast of Colombia.

Tropical spastic paraparesis (TSP) is a retroviral disease characterized predominantly by a chronic myelopathy and progressive leg weakness. Four patients from the northern coast of Columbia with chronic spastic paraparesis and serum positivity for antibodies to human T cell lymphotropic virus type 1 by enzyme-linked immunosorbent assay and Western blot are reported. All patients had mixed ethnic origins (white, black, and amerindian). This is the first report of TSP on the Caribbean coast of Colombia. This study extends the geographic boundaries of TSP in the Caribbean basin.

Dorsal penile nerve block in neonatal circumcision: chloroprocaine versus lidocaine.

Dorsal penile nerve blocking (DPNB) has been used with success in decreasing neonatal stress during circumcision. This study was designed to confirm the effectiveness of lidocaine in DPNB and to demonstrate that chloroprocaine, a shorter acting anesthetic, is as effective in blocking circumcision stress as lidocaine, but, because of its shorter plasma elimination half-life and time of onset of action, is safer. Five groups of 15 neonates were matched for weight, age, and Apgar scores and randomly assigned to a control group, one lidocaine group and three chloroprocaine groups with 2-, 3- and 5-minute postinjection waiting periods. Each neonate was subjected to six events during circumcision for which heart rate, tissue oxygenation, and cry duration were recorded. We found that, as in previous investigations, DPNB with lidocaine was effective in reducing neonatal stress, as was evident from decreased excursion from baseline heart rate, tissue oxygenation, and cry duration when compared with the control group (nonblocked). Furthermore, chloroprocaine DPNB approximates the effectiveness of lidocaine, as was evident from decreased change from baseline cry duration, tissue oxygenation, and heart rate during the most stressful events, particularly in the 3-minute wait chloroprocaine group. This more rapid onset of regional anesthesia decreases DPNB circumcision time and benefits patients, parents, and physicians.

Adolescent blood pressure survey: Tulsa, Oklahoma, 1987 to 1989.

The study goals were to document the incidence of elevated blood pressure (BP) values in public high school students in Tulsa, Oklahoma; to determine whether age and sex are risk factors; and to encourage adolescents with abnormal screening BP values to seek medical care. Over a 2-year period, 5537 adolescents aged 14 to 19 years were evaluated by a mass screening method. Blood pressure was measured once between 8:30 and 9:30 AM, with the students seated. Korotkoff phases 1 and 5 were recorded as systolic and diastolic BP. According to the criteria of the Second Task Force on Hypertension in Children and Adolescents, 334 students had elevated BP values (either systolic, diastolic, or both) (an incidence of 6%). Boys had an incidence of elevated systolic BP of 5.8%, while girls had a 2.8% incidence, a difference that might have been expected because of the generally higher incidence among men in the adult population. The incidence of elevated diastolic BP was 2.8% in boys and 2.1% in girls. Statistically significant differences between boys and girls mean systolic and diastolic elevations were found, but were not considered clinically significant. An instructional mailing was done in an effort to stimulate follow-up medical care for those with abnormal findings, but its effect was not measured.