Adding Intermittent Vibration to Varied-intensity Work Intervals: No Extra Benefit.

Varied-intensity work intervals have been shown to induce higher fractions of maximal oxygen uptake during high-intensity interval training compared with constant-intensity work intervals. We assessed whether varied-intensity work intervals combined with intermittent vibration could further increase cyclists' fraction of maximal oxygen uptake to potentially optimise adaptive stimulus. Thirteen cyclists (V̇O2max: 69.7±7.1 ml·kg-1·min-1) underwent a performance assessment and two high-intensity interval training sessions. Both comprised six 5-minute varied-intensity work intervals within which the work rate was alternated between 100% (3×30-second blocks, with or without vibration) and 77% of maximal aerobic power (always without vibration). Adding vibration to varied-intensity work intervals did not elicit a longer time above ninety percent of maximal oxygen uptake (415±221 versus 399±209 seconds, P=0.69). Heart rate- and perceptual-based training-load metrics were also not affected (all P≥0.59). When considering individual work intervals, no between-condition differences were found (fraction of maximal oxygen uptake, P=0.34; total oxygen uptake, P=0.053; mean minute ventilation, P=0.079; mean heart rate, P=0.88; blood lactate concentration, P=0.53; ratings of perceived exertion, P=0.29). Adding intermittent vibration to varied-intensity work intervals does not increase the fraction of maximal oxygen uptake elicited. Whether intermittent exposure to vibration can enhance cyclists' adaptive stimulus triggered by high-intensity interval training remains to be determined.

Long-term effects of daily postprandial physical activity on blood glucose: a randomized controlled trial.

Previous studies have shown that a bout of moderate or light postprandial physical activity effectively blunts the postprandial increase in blood glucose. The objective of this study was to test whether regular light postprandial physical activity can improve glycemia in persons with hyperglycemia or with a high risk of hyperglycemia. We randomized 56 participants to an intervention or a control group. They were diagnosed as hyperglycemic, not using antidiabetics, or were categorized as high-risk individuals for type 2 diabetes. The intervention group was instructed to undertake a minimum 30 min of daily light physical activity, starting a maximum of 30 min after a meal in addition to their usual physical activity for 12 weeks. The control group maintained their usual lifestyle. Blood samples were taken pre- and post-test. Forty participants completed the study and are included in the results. The self-reported increase in daily physical activity from before to within the study period was higher in the intervention group compared with control (41 ± 25 vs. 2 ± 16 min, p < 0.001). Activity diaries and accelerometer recordings supported this observation. The activity in the intervention group started earlier after the last meal compared with control (30 ± 13 vs. 100 ± 57 min, p = 0.001). There were no within- or between-group differences in any glycemic variable from pre- to post-test. In conclusion, the present study does not seem to support the notion that regular light postprandial physical activity improves blood glucose in the long term in persons with hyperglycemia or with high risk of hyperglycemia.

Vitamin C and E supplementation hampers cellular adaptation to endurance training in humans: a double-blind, randomised, controlled trial.

In this double-blind, randomised, controlled trial, we investigated the effects of vitamin C and E supplementation on endurance training adaptations in humans. Fifty-four young men and women were randomly allocated to receive either 1000 mg of vitamin C and 235 mg of vitamin E or a placebo daily for 11 weeks. During supplementation, the participants completed an endurance training programme consisting of three to four sessions per week (primarily of running), divided into high-intensity interval sessions [4-6 × 4-6 min; >90% of maximal heart rate (HRmax)] and steady state continuous sessions (30-60 min; 70-90% of HRmax). Maximal oxygen uptake (VO2 max ), submaximal running and a 20 m shuttle run test were assessed and blood samples and muscle biopsies were collected, before and after the intervention. Participants in the vitamin C and E group increased their VO2 max (mean ± s.d.: 8 ± 5%) and performance in the 20 m shuttle test (10 ± 11%) to the same degree as those in the placebo group (mean ± s.d.: 8 ± 5% and 14 ± 17%, respectively). However, the mitochondrial marker cytochrome c oxidase subunit IV (COX4) and cytosolic peroxisome proliferator-activated receptor-γ coactivator 1 α (PGC-1α) increased in the m. vastus lateralis in the placebo group by 59 ± 97% and 19 ± 51%, respectively, but not in the vitamin C and E group (COX4: -13 ± 54%; PGC-1α: -13 ± 29%; P ≤ 0.03, between groups). Furthermore, mRNA levels of CDC42 and mitogen-activated protein kinase 1 (MAPK1) in the trained muscle were lower in the vitamin C and E group than in the placebo group (P ≤ 0.05). Daily vitamin C and E supplementation attenuated increases in markers of mitochondrial biogenesis following endurance training. However, no clear interactions were detected for improvements in VO2 max and running performance. Consequently, vitamin C and E supplementation hampered cellular adaptations in the exercised muscles, and although this did not translate to the performance tests applied in this study, we advocate caution when considering antioxidant supplementation combined with endurance exercise.