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Objective @#To investigate the effects of intra-articular injection of alendronate on the mandibular condyle in ovariectomized rats.@*Methods @#Sixty female rats were randomly divided into five groups: ovariectomy with vehicle treatment alone, early alendronate treatment at ovariectomy, late alendronate treatment at 4 weeks after ovariectomy, shamoperation with vehicle treatment, and the normal control rats. The changes in subchondral bone were evaluated by micro-computed tomography (Micro-CT), tartrate-resistant acid phosphatase (TRAP) staining and real-time quantitative polymerase chain reaction (RT-PCR). @*Results @# Compared with late alendronate treatment, early alendronate treatment improved microstructural properties of the subchondral bone, with higher bone volume ratio (46.4 + 2.5 vs 37.5 + 2.1; P= 0.038), increased trabecular thickness (47.3 + 1.7 vs 34.6 + 1.4; P = 0.029), elevated trabecular number (8.5 + 0.6 vs 6.2 + 0.3; P = 0.041) and lower trabecular separation (30.2 + 1.6 vs 37.7 + 2.6; P = 0.034). Fewer TRAP-positive cells (4.2 + 0.2 vs 6.8 + 0.4; P = 0.019) and a higher OPG/RANKL ratio (0.38 + 0.01 vs 0.25 + 0.03; P = 0.043) in the subchondral bone were observed in the animals with early treatment group compared to late treatment or ovariectomy/vehicle treatment group. @*Conclusion @#Our results suggest the therapeutic potential of intra-articular alendronate injection in the treatment of osteoporosis-associated temporomandibular disorders.
RESUMO
OBJECTIVE: To compare the clinical effects between coblation combined with ozone nucleus pulposus ablation and single radiofrequency ablation of nucleus pulposus in treating a simple segment inclusive lumbar intervertebral disc herniation. METHODS: From June 2009 to June 2011,33 patients with lumbar intervertebral disc herniation were treated with coblation combined with ozone nucleus pulposus ablation (group A),including 19 males and 14 females,ranging in age from 20 to 60 years old with an average of (40.4+/-8.8) years old,in the course of disease from 12 to 38 months with an average of (19.9+/-5.8) months;31 patients were treated with single radiofrequency ablation of nucleus pulposus(group B),ineluding 18 males and 13 females,ranging in age from 20 to 60 years old with an average of (39.8+/-7.3) years old,in the course of disease from 12 to 48 months with an average of (19.2+/-8.1) months. Visual analogue score(VAS) and JOA score system was respectively used to evaluate pain and function after operation. RESULTS: All patients were followed up more than 1 year. No injuries of nerve root and cauda equina nerve,infection were found. There was no significant difference in VAS score between two groups at 1 month after operation (P>0.05),but at 12 months after operation,VAS score of group A was better than that of group B (P<0.05). There was no significant difference in JOA score between two groups at 12 months after operation (P>0.05). According to the functional improvement rate to evaluate the clinical effects,in group A,9 cases got excellent results, 21 good,3 fair;and in group B,6 excellent,18 good,7 fair. Clinical effects of group A was better than that of group B (P<0.05). CONCLUSION: Clinical effects of coblation combined with ozone nucleus pulposus ablation is better in treating a simple segment inclusive lumbar intervertebral disc herniation.