Precursory elements of safety culture: Exploratory analyses of engineering students' safety attitudes.

INTRODUCTION: Safety culture as a concept has been well-researched in the literature. There is less work, however, on how individuals entering the workforce acquire and partake in safety culture over time and how they might be primed to partake in the positive elements of safety culture. METHOD: We begin this exploration by surveying engineering students' attitudes toward safety and experiences with safety education at the Georgia Institute of Technology (n = 316). RESULTS: We find disparities among engineering disciplines, where some majors have more negative views toward safety than others. This may point to the need for more [effective] safety education to prevent negative attitudes toward safety in the workplace. In addition to describing trends among engineering students' attitudes, this study also uses factor analysis to characterize the latent constructs of precursory safety culture: the safety-related attitudes that may direct how people engage with safety culture as early-career engineers. PRACTICAL APPLICATIONS: The analysis provides a conceptual construction of precursor safety culture attitudes, which can serve as a guide to future measurement efforts.

Metrics of Mobility: Assessing the Impact of COVID-19 on Travel Behavior.

The COVID-19 pandemic disrupted typical travel behavior worldwide. In the United States (U.S.), government entities took action to limit its spread through public health messaging to encourage reduced mobility and thus reduce the spread of the virus. Within statewide responses to COVID-19, however, there were different responses locally. Likely some of these variations were a result of individual attitudes toward the government and health messaging, but there is also likely a portion of the effects that were because of the character of the communities. In this research, we summarize county-level characteristics that are known to affect travel behavior for 404 counties in the U.S., and we investigate correlates of mobility between April and September (2020). We do this through application of three metrics that are derived via changepoint analysis-initial post-disruption mobility index, changepoint on restoration of a "new normal," and recovered mobility index. We find that variables for employment sectors are significantly correlated and had large effects on mobility during the pandemic. The state dummy variables are significant, suggesting that counties within the same state behaved more similarly to one another than to counties in different states. Our findings indicate that few travel characteristics that typically correlate with travel behavior are related to pandemic mobility, and that the number of COVID-19 cases may not be correlated with mobility outcomes.

Pre-existing and de novo humoral immunity to SARS-CoV-2 in humans

Several related human coronaviruses (HCoVs) are endemic in the human population, causing mild respiratory infections1. Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), the etiologic agent of Coronavirus disease 2019 (COVID-19), is a recent zoonotic infection that has quickly reached pandemic proportions2,3. Zoonotic introduction of novel coronaviruses is thought to occur in the absence of pre-existing immunity in the target human population. Using diverse assays for detection of antibodies reactive with the SARS-CoV-2 spike (S) glycoprotein, we demonstrate the presence of pre-existing humoral immunity in uninfected and unexposed humans to the new coronavirus. SARS-CoV-2 S-reactive antibodies were readily detectable by a sensitive flow cytometry-based method in SARS-CoV-2-uninfected individuals and were particularly prevalent in children and adolescents. These were predominantly of the IgG class and targeted the S2 subunit. In contrast, SARS-CoV-2 infection induced higher titres of SARS-CoV-2 S-reactive IgG antibodies, targeting both the S1 and S2 subunits, as well as concomitant IgM and IgA antibodies, lasting throughout the observation period of 6 weeks since symptoms onset. SARS-CoV-2-uninfected donor sera also variably reacted with SARS-CoV-2 S and nucleoprotein (N), but not with the S1 subunit or the receptor binding domain (RBD) of S on standard enzyme immunoassays. Notably, SARS-CoV-2-uninfected donor sera exhibited specific neutralising activity against SARS-CoV-2 and SARS-CoV-2 S pseudotypes, according to levels of SARS-CoV-2 S-binding IgG and with efficiencies comparable to those of COVID-19 patient sera. Distinguishing pre-existing and de novo antibody responses to SARS-CoV-2 will be critical for our understanding of susceptibility to and the natural course of SARS-CoV-2 infection.