RESUMO
Twelve neurologically normal infants (age 2.9+/-0.9 months) with peptic esophagitis (grade 2) who did not respond to cimetidine (in addition to positioning, cisapride, and Gaviscon) were treated with omeprazole, 0.5 mg/kg once a day, for 6 weeks. The effectiveness of omeprazole was evaluated in all infants by clinical assessment and endoscopy before and after treatment and by 24-hour gastric pH monitoring during treatment in seven infants. Omeprazole therapy led to a marked decrease in symptoms, endoscopic and histologic signs of esophagitis, and intragastric acidity.
Assuntos
Antiulcerosos/uso terapêutico , Esofagite Péptica/tratamento farmacológico , Omeprazol/uso terapêutico , Cimetidina/uso terapêutico , Antagonistas dos Receptores H2 da Histamina/uso terapêutico , Humanos , Lactente , Falha de Tratamento , Resultado do TratamentoAssuntos
Anticonvulsivantes/efeitos adversos , Densidade Óssea/efeitos dos fármacos , Osteoporose/induzido quimicamente , Ácido Valproico/efeitos adversos , Adolescente , Anticonvulsivantes/uso terapêutico , Epilepsia Tônico-Clônica/tratamento farmacológico , Humanos , Masculino , Fraturas da Coluna Vertebral/etiologia , Vértebras Torácicas/lesões , Ácido Valproico/uso terapêuticoRESUMO
Significant differences (p < 0.0001) were demonstrated in lymphocyte subpopulations both in cord blood and in venous blood samples obtained at day 5 from the same healthy infants. Numbers of T lymphocytes increased, especially CD4+/CD45RA+ cells, whereas numbers of B lymphocytes and natural killer cells decreased without changes in CD8+ and other cytotoxic cells.