[A role of D-dimer and fibrinopeptide A in diagnosis of a hemostasis system disorders].

The investigations, concerning detection of the hemostasis system activation, were done in 26 patients, suffering various critical morbid states (an acute pancreatitis). The contents of products of the enzymes lysis of coagulation system and fibrinolytic system constitute one of the most precise indices. Fibrinopeptid A (FpA) is considered one of the most secure indices, confirming intravascular thrombin formation, and D-dimer--of a fibrin formation. In the patients examined a trustworthy increase of a D-dimer and FpA contents was registered, witnessing the hemostasis system activation in an acute pancreatitis as well as an excessive formation and lysis of fibrin. D-dimer and FpA contents in a plasma constitutes an important diagnostic index, its determination secures the possibility of early diagnosis and control of a hemostasis system disorders.

[Changes of hemostasis system and activity of 5-nucleotidase in the blood of patients during an acute period after the brain contusion].

Craniocerebral trauma (CCT) is an actual problem of modern medicine due to its high mortality incidence. Changes in hemostasis system may complicate the disease course and to cause the disseminated intravascular clotting syndrome occurrence. Early diagnosis and correction of such disorders would permit to escape complications and to lower mortality. Thromboplastinemia constitutes the main cause of hypercoagulation in CCT. Enzyme 5-nucleotidase is closely connected with thromboplastin. The raising of this enzyme activity may constitute an early diagnostic sign of hypercoagulation.