Ultrasonic- and Ultrasound-assisted Improvement of Silhouette of the Torso: Bone Structure High-definition Remodeling (Part I).

Background: High-definition liposculpture allowed plastic surgeons to achieve better aesthetic results by carving the underlying muscles and contours in a new way. Several authors have improved the original technique by adding other procedures and new technologies. We designed a new improvement by incorporating bone transformation surgery to overcome the lack of silhouette at the waist and, as a result, optimize the breast-waist-hip ratios. Methods: We carried out a prospective multicenter study, with five different surgeons performing the same rib remodeling technique for waist definition. We used an ultrasonic piece for costal corticotomy and real-time ultrasound imaging to perform green-stick fractures over the last two or three floating ribs. Ours is a new technique based on the prior one described by Kudzaev. Results: We reported 131 consecutive patients who were enrolled in this study. Waistline diameter decreased an average of 8 cm after surgery (P < 0.05). Most patients were women (n = 125, 95.4%). No major complications were reported. Most common complication was prolonged pain, with only three cases of contour asymmetry, all of which were attributable to noncompliance of constantly wearing the corset + compressive garments. Patients reported a high satisfaction rate and fast recovery (Body-QoL survey). Conclusions: Ultrasonic- and ultrasound- assisted indentation surgery of the thorax is a safe and reliable technique for waistline definition, with a high satisfaction rate, almost-invisible scars, and minimal risk for complications. Incorporation of high-definition liposculpture to rib remodeling opens up a new horizon for bone structure modification surgery (S-high-definition remodeling) that can be safely performed for patients who seek better aesthetic outcomes in body contouring.

Copy number variation profiling in pharmacogenetics CYP-450 and GST genes in Colombian population.

BACKGROUND: Copy Number variation (CNVs) in genes related to drug absorption, distribution, metabolism and excretion (ADME) are relevant in the interindividual variability of drug response. Studies of the CNVs in ADME genes in Latin America population are lacking. The objective of the study was to identify the genetic variability of CNVs in CYP-450 and GST genes in a subgroup of individuals of Colombian origin. METHODS: Genomic DNA was isolated from 123 healthy individuals from a Colombian population. Multiplex Ligation-Dependent Probe Amplification (MLPA) was performed for the identification of CNVs in 40 genomic regions of 11 CYP-450 and 3 GST genes. The genetic variability, allelic and genotypic frequencies were analyzed. RESULTS: We found that 13 out of 14 genes had CNVs: 5 (35.7%) exhibited deletions and duplications, while 8 (57.1%) presented either deletions or duplications.. 33.3% of individuals carried deletions and duplications while 49.6% had a unique type of CNV (deletion or duplication). The allelic frequencies of the CYP and GST genes were 0 to 47.6% (allele null), 0 to 17.5% (duplicated alleles) and 37 to 100% (normal alleles). CONCLUSIONS: Our results describe, for the first time, the genomic profile of CNVs in a subgroup of Colombian population in GST and CYP-450 genes. GST genes indicated greater genetic variability than CYP-450 genes. The data obtained contributes to the knowledge of genetic profiles in Latin American subgroups. Although the clinical relevance of CNVs has not been fully established, it is a valuable source of pharmacogenetic variability data with potential involvement in the response to medications.

Removal of indigo carmine dye by electrocoagulation using magnesium anodes with polarity change.

The aim of this study was to evaluate the performance of high purity magnesium and the magnesium-aluminum-zinc alloy AZ31 as sacrificial anodes in an electrocoagulation process with polarity change for the treatment of synthetic indigo carmine solution. It was studied the effect of the main parameters such as temperature, anodic material, current density, initial dye concentration, and agitation speed on the diminishing of indigo carmine concentration and non-purgeable organic carbon. Also, image analysis was used in conjunction with zeta potential measurements to understand the mechanism of flocs formation. The best results were 80% and 96% removal for non-purgeable organic carbon and dye content respectively at room temperature, by using turbulent regime, initial dye concentration of 100 mg L-1 and 50 A m-2 as current density with AZ31 alloy as electrodes. Particularly, high purity magnesium reached 75% in non-purgeable organic carbon removal and 86% in dye removal at the conditions described above. Finally, an additional improvement of 43% in the diminishing of the organic carbon content was observed when polarity change was used, a phenomenon that was attributed to the distribution of the oxidation reaction between electrodes, avoiding the saturation of the surface with oxide and hydroxide layers. Major areas and major fractal dimension were obtained by using a polarity change.

Shape-morphing architected sheets with non-periodic cut patterns.

We investigate the out-of-plane shape morphing capability of single-material elastic sheets with architected cut patterns that result in arrays of tiles connected by flexible hinges. We demonstrate that a non-periodic cut pattern can cause a sheet to buckle into three-dimensional shapes, such as domes or patterns of wrinkles, when pulled at specific boundary points. These global buckling modes are observed in experiments and rationalized by an in-plane kinematic analysis that highlights the role of the geometric frustration arising from non-periodicity. The study focuses on elastic sheets, and is later extended to elastic-plastic materials to achieve shape retention. Our work illustrates a scalable route towards the fabrication of three-dimensional objects with nonzero Gaussian curvature from initially-flat sheets.