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1.
PLoS One ; 19(3): e0293616, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38527091

RESUMO

To properly control the network of the power system and ensure its protection, Phasor measurement units (PMUs) must be used to monitor the network's operation. PMUs can provide synchronized real-time measurements. These measurements can be used for state estimation, fault detection and diagnosis, and other grid control applications. Conventional state estimation methods use weighting factors to balance the different types of measurements, and zero injection measurements can lead to large weighting factors that can introduce computational errors. The offered methods are designed to ensure that these zero injection criteria can be strictly satisfied while calculating the voltage profile and observability of the various distribution networks without sacrificing computing efficiency. The proposed method's viability is assessed using standard IEEE distribution networks. MATLAB coding is used to simulate the case analyses. Overall, the study provides a valuable contribution to the field of power distribution system monitoring and control by simplifying the process of determining the optimal locations for PMUs in a distribution network and assessing the impact of ZI buses on the voltage profile of the system.


Assuntos
Sistemas Computacionais , Tecnologia , Injeções
2.
Public Health Rep ; 139(1): 54-58, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-36905313

RESUMO

OBJECTIVE: Reports on recent mortality trends among adults aged ≥65 years are lacking. We examined trends in the leading causes of death from 1999 through 2020 among US adults aged ≥65 years. METHODS: We used data from the National Vital Statistics System mortality files to identify the 10 leading causes of death among adults aged ≥65 years. We calculated overall and cause-specific age-adjusted death rates and then calculated the average annual percentage change (AAPC) in death rates from 1999 through 2020. RESULTS: The overall age-adjusted death rate decreased on average by 0.5% (95% CI, -1.0% to -0.1%) per year from 1999 through 2020. Although rates for 7 of the top 10 causes of death decreased significantly, the rates of death from Alzheimer disease (AAPC = 3.0%; 95% CI, 1.5% to 4.5%) and from unintentional injuries (AAPC = 1.2%; 95% CI, 1.0% to 1.4%), notably falls (AAPC = 4.1%; 95% CI, 3.9% to 4.3%) and poisoning (AAPC = 6.6%; 95% CI, 6.0% to 7.2%), increased significantly. CONCLUSION: Public health prevention strategies and improved chronic disease management may have contributed to decreased rates in the leading causes of death. However, longer survival with comorbidities may have contributed to increased rates of death from Alzheimer disease and unintentional falls.


Assuntos
Doença de Alzheimer , Estatísticas Vitais , Adulto , Humanos , Estados Unidos/epidemiologia , Causas de Morte , Doença Crônica , Registros , Mortalidade
3.
Natl J Maxillofac Surg ; 14(2): 271-276, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37661982

RESUMO

Background: The temporomandibular joint (TMJ) is a unique structure of the body where the mandible, one of the important facial bones, articulates with the temporal part of the skull bone. Obtaining morphometric dimensions for mandibular condyle is important for performing an accurate pre/postoperative assessment, planning temporomandibular and orthognathic surgeries, and applications in forensic sciences in context to the Indian population, which is presently based on dimensions of Caucasian population from available literature. Several investigators noticed the variation in the craniofacial morphology in different ethnic groups and vary according to age and sex. This study aims to provide the normal dimensions of the mandibular condyle in the Indian population, which would be providing racially specific values for diagnosis, treatment planning of surgeries involving condylar processes such as rigid internal fixation of TMJ region, congenital deformities, and customizing TMJ prosthesis concerning these measurements. Aim of the Study: To measure the change in dimensions of mandibular condyle according to age and sex using computed topographic scan imaging. Objectives of the Study: 1. To measure the dimensions of mandibular condyle. 2. To evaluate any age-related changes in dimensions. of mandibular condyle (intercohort comparison). 3. To evaluate any sex-related changes in dimensions of mandibular condyle (intercohort comparison). Materials and Methods: A retrospective analytical cohort study. Inclusion Criteria: Indian adult males and females aged between 20 and 50 years who underwent facial computed tomography (CT) for any reason (e.g., head injury). Exclusion Criteria: Patients with congenital or acquired dentofacial deformities involving TMJ. Data Collection: By assessing the morphometric dimensions of condyle of mandible using CT scan images. Result/Conclusion: Mean condylar dimensions for each age/sex cohort are established; however, no significant change as per age and sex in condylar dimensions in the Indian population is noted.

4.
Sci Rep ; 13(1): 5553, 2023 Apr 05.
Artigo em Inglês | MEDLINE | ID: mdl-37020132

RESUMO

The role of ocean variability is at a focal point in improving the weather and climate forecasts at different spatial and temporal scales. We study the effect of antecedent southwestern Indian Ocean mean sea level anomaly (MSLA) and sea surface temperature anomalies (SSTA) as a proxy to upper ocean heat capacitance on all India summer monsoon rainfall (AISMR) during 1993-2019. SSTA and MSLA over the southwestern Indian Ocean (SWIO) have been influenced by El Niño-Southern Oscillation (ENSO), the impact of ENSO-induced SWIO variability was low on rainfall variability over several homogeneous regions. Rainfall over northeast (NE) and North India (EI) has been modulated by ENSO-induced SSTA and MSLA over SWIO, thus effecting the total AISMR magnitude. The ENSO-induced changes in heat capacitance (SSTA and MSLA) over SWIO during antecedent months has less impact on west coast of India, central India and North India (NI) rainfall variability. The long-term trend in pre-monsoonal SSTA and MSLA over SWIO shows decreasing rainfall trend over NI, NE, and EI in the recent time. Furthermore, the cooler (warmer) anomaly over the western Indian Ocean affects rainfall variability adversely (favourably) due to the reversal of the wind pattern during the pre-monsoon period. While SSTA and MSLA are increasing in the SWIO, large-scale variability of these parameters during preceding winter and pre-monsoon months combined with surface winds could impact the inter-annual AISMR variability over homogeneous regions of India. Similarly, from an oceanic perspective, the antecedent heat capacitance over SWIO on an inter-annual time scale has been the key to the extreme monsoon rainfall variability.

5.
Natl J Maxillofac Surg ; 14(3): 369-382, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-38273919

RESUMO

The alveolar ridge split and expansion (ARSE) can be performed using conventional devices (osteotome/chisel) or modern devices (ultrasonographic [USG], motorized ridge expansion [MRE], etc.). The aim of this systematic review was to evaluate the effect of modern devices for ARSE. This review has been registered at PROSPERO under the number CRD42020213264. A systematic search was conducted by two reviewers independently in databases PubMed, MEDLINE, Cochrane Central Register of Controlled Trials, Grey Open, Hand search of reference lists of relevant studies, and previously published systematic reviews. The article published until September 2020 were searched for this review. The searches identified 24 eligible studies, twenty-two cohort and two randomized control trial studies. A total of 1287 dental implants were installed in 634 patients with the age range of 17-70 years and a minimum of 3 months of follow-up. Ten articles of USG device and seven of MRE device were finally evaluated for metanalysis. The mean ridge width gain was 3.40 mm (USG device) and 2.83 mm (MRE device). The overall implant survival rate was 98.07%. Mean width gain between USG and MRE devices was significantly different (P < 0.0001, HS). Test of heterogeneity was significant (Q = 88.3877, P < 0.0001, HS) and there was no publication bias (Intercept = 6.6634, P = 0.6142, NS) by Egger's test. The most commonly used devices were USG and MRE. USG is more effective for osteo-mobilization type and MRE device for minimally invasive osteo-condensation.

6.
Opt Lett ; 47(10): 2554-2557, 2022 May 15.
Artigo em Inglês | MEDLINE | ID: mdl-35561399

RESUMO

In this Letter, we demonstrate experimentally and verify numerically the excitation of Berreman modes that propagate in a dielectric film of uniaxial anisotropic nanoporous alumina grown on an aluminum substrate. It is an air-dielectric-metal asymmetric polaritonic system with a real part of the effective permittivity having a value near zero. The modes are excited at a wavelength lower than the epsilon-near-zero wavelength region. Minimum reflection is observed for the mid-infrared p-polarized light, while maximum reflection is observed for the s-polarized light. The experimental results are numerically reproduced for both p- and s-polarized light and confirm the excitation of Berreman modes in the system. At the exciting wavelength, the field is confined in the dielectric region near the air-dielectric interface. The reported system is straightforward and can be easily fabricated over a large scale and is helpful in a variety of mid-infrared applications such as thermal management systems, sensors, passive radiative cooling devices, nonlinear applications, and terahertz frequency generation.

7.
J Korean Assoc Oral Maxillofac Surg ; 48(2): 122-124, 2022 Apr 30.
Artigo em Inglês | MEDLINE | ID: mdl-35491144

RESUMO

Various techniques are well documented to obtain anatomic reduction, such as reduction forceps, manual reduction, or a combination of these methods. However, these techniques have inherent drawbacks. We propose a new intra-operative technique for anatomic reduction using screw-wire traction for open reduction and internal fixation of mandibular fractures.

8.
Sci Rep ; 12(1): 7400, 2022 May 05.
Artigo em Inglês | MEDLINE | ID: mdl-35513498

RESUMO

Explorations into the photonic analogs of topological materials have garnered significant research interest due to their application potential. Particularly in planar systems, the prospects of engendering extinguishable topological states can have wide-ranging implications. With an objective of employing these concepts for thermal emission engineering, here, we design and numerically investigate a quasi-monochromatic highly directional mid-infrared source elicited from inversion symmetry-protected topological interface states. Notably, by relying on the architecture of electro-optic effect-induced topological phase transitions, we introduce the possibility of ultrafast switching of thermal radiation. These reversible phase transitions, being free from carrier transport are inherently fast and evoke thermal emission modulation with a modulation depth upto 0.99. Specifically, our platform exhibits a near-perfect extinguishable spectral emission peak at [Formula: see text]m with a quality factor of over 18500, displaying negligible parasitic emissions. Furthermore, the optimized interface state manifests itself for only one of the polarization modes, resulting in polarized emission under resonance conditions. To establish a methodical approach to parameter optimization, we also model our platform as a leaky mode resonator using the framework of temporal coupled-mode theory. We believe, our findings can provide a way forward in establishing complete control over the optical characteristics of the infrared thermal emitters.

9.
Artigo em Inglês | WPRIM (Pacífico Ocidental) | ID: wpr-926219

RESUMO

Various techniques are well documented to obtain anatomic reduction, such as reduction forceps, manual reduction, or a combination of these methods. However, these techniques have inherent drawbacks. We propose a new intra-operative technique for anatomic reduction using screw-wire traction for open reduction and internal fixation of mandibular fractures.

10.
J Safety Res ; 79: 38-44, 2021 12.
Artigo em Inglês | MEDLINE | ID: mdl-34848018

RESUMO

INTRODUCTION: In the United States, fall-related emergency department (ED) visits among older adults (age 65 and older) have increased over the past decade. Studies document seasonal variation in fall injuries in other countries, while research in the United States is inconclusive. The objectives of this study were to examine seasonal variation in older adult fall-related ED visits and explore if seasonal variation differs by the location of the fall (indoors vs. outdoors), age group, and sex of the faller. METHODS: Fall-related ED visit data from the National Electronic Injury Surveillance System-All Injury Program were analyzed by season of the ED visit, location of the fall, and demographics for adults aged 65 years and older. RESULTS: Total fall-related ED visits were higher during winter compared with other seasons. This seasonal variation was found only for falls occurring outdoors. Among outdoor falls, the variation was found among males and adults aged 65 to 74 years. The percentages of visits for weather-related outdoor falls were also higher among males and the 65-74 year age group. CONCLUSIONS: In 2015, there was a seasonal variation in fall-related ED visits in the United States. Weather-related slips and trips in winter may partially account for the seasonal variation. PRACTICAL IMPLICATIONS: These results can inform healthcare providers about the importance of screening all older adults for fall risk and help to identify specific patients at increased risk during winter. They may encourage community-based organizations serving older adults to increase fall prevention messaging during winter.


Assuntos
Acidentes por Quedas , Serviço Hospitalar de Emergência , Acidentes por Quedas/prevenção & controle , Idoso , Humanos , Aplicação da Lei , Masculino , Estações do Ano , Estados Unidos/epidemiologia , Tempo (Meteorologia)
11.
Indian J Dent Res ; 32(1): 87-91, 2021.
Artigo em Inglês | MEDLINE | ID: mdl-34269243

RESUMO

INTRODUCTION: The way postoperative care instructions are presented by the professional (verbal and/or written) is the key element that influences quality of treatment. Hence, the aim of the present study was planned to assess the patient's compliance with postoperative care instructions given in different forms following the surgical removal of impacted lower third molars. MATERIALS AND METHODS: Forty patients scheduled to undergo surgical extraction of impacted lower third molars under local anesthetic were randomly assigned to one of two groups. Before surgery, basic demographic data about age, gender, deleterious habits were recorded. Group A (verbal postoperative care instructions) and Group B (verbal + pictorial postoperative care instructions) were given with a prescription of medication after the surgical removal of impacted lower third molars. Patient were recalled on 7th postoperative day for suture removal and asked to fill the closed-ended questionnaire. RESULTS: Out of 20 patients in each group, one patient from Group A was eliminated as the patient did not turn for the follow-up visit. Therefore, result was based on 39 patients (19 males and 20 females) of age 28-41 years with a mean of 33.2 years (SD ± 3.3). The significance level was set at P < 0.05. The compliance of patients regarding gargling with lukewarm water and mouth opening exercises was seen more significantly in Group B (Pictorial + Verbal). CONCLUSION: Verbal instructions are inadequate due to difficulty in retention. Hence, a pictorial form of delivering postoperative instructions increases information retention which significantly increases pain relief without extending the analgesic consumption.


Assuntos
Dente Serotino , Dente Impactado , Adulto , Analgésicos , Feminino , Humanos , Masculino , Dente Serotino/cirurgia , Dor Pós-Operatória/prevenção & controle , Cooperação do Paciente , Extração Dentária , Dente Impactado/cirurgia
12.
J Phys Condens Matter ; 33(2): 025803, 2021 Jan 13.
Artigo em Inglês | MEDLINE | ID: mdl-32942268

RESUMO

Zero and low field nuclear magnetic resonance measurements have been performed on MAX phase samples (Cr1-x Mn x )2AC with A = Ge and Ga in order to obtain local microscopic information on the nature of magnetism in this system. Our results unambiguously provide evidence for the existence of long-range magnetic order in (Cr0.96Mn0.04)2GeC and for (Cr0.93Mn0.07)2GaC, but not for (Cr0.97Mn0.03)2GaC. We point to a possible dependence of long range magnetic order in these MAX phase compounds on the A atom.

13.
Minerva Surg ; 76(2): 173-178, 2021 04.
Artigo em Inglês | MEDLINE | ID: mdl-32773741

RESUMO

BACKGROUND: Maxillofacial trauma is complex kind of injury that requires complex treatment, hence it is difficult in selecting the type of intubation technique depending on trauma. With the advent of various technologies and devices, surgeon and anesthetist should select right method of intubation that will benefit patient. METHODS: In a retrospective study, patients of either sex, admitted in Lata Mangeshkar Hospital under Oral and Maxillofacial Surgery unit for treating maxillofacial trauma operated during year 2018 to year 2019 as elective basis were studied. RESULTS: Of 78 patients, the majority (37, 47.4%) were in the 21-30 age group, followed by the young adults 31-40 years age group (19, 24.3%). Mandible fracture was found to be the most common injury in 35 patients (44.3%) followed by fracture zygoma in 26(33.3%) patients and panfacial in eight patients (10.2%). There was frontal bone fracture in three patients (3.8%). Fiberoptic intubation under sedation was carried out in 34 (43.5%) and submental intubation in 20 (25.6%) and nasal intubation with direct visualization of vocal cords in 14 (17.9%) and blind nasal intubation was performed in eight (10.2%). CONCLUSIONS: The results of this study suggest that the old concept of securing the airway in difficult situation by tracheostomy should be revised.


Assuntos
Traumatismos Maxilofaciais , Fraturas Cranianas , Adulto , Humanos , Intubação Intratraqueal/efeitos adversos , Traumatismos Maxilofaciais/cirurgia , Estudos Retrospectivos , Fraturas Cranianas/cirurgia , Traqueostomia , Adulto Jovem
14.
Appl Opt ; 59(17): E118-E125, 2020 Jun 10.
Artigo em Inglês | MEDLINE | ID: mdl-32543522

RESUMO

A tri-layer metamaterial structure with enhanced absorption is demonstrated at infrared wavelengths by coating the top surface of the metamaterial absorber with an additional thin layer of dielectric material. The metamaterial absorber, which consists of a micrometer-sized metallic circular patch separated from a metal ground plane by a dielectric spacer layer, when coated with a supplementary protective dielectric layer on the top, shows a spectral red shift of the peak absorption along with a change in the absorption amplitude. The increase or decrease in absorption arises basically from an interference phenomenon of light reflected from the surface of the protective dielectric and the surface of metamaterial structures, and is highly dependent on the thickness of the top dielectric layer. The protective dielectric coatings provide an alternative way to modify and optimize the absorption in a metamaterial absorber along with a robustness that protects metamaterial structures from environmental and mechanical degradation.

15.
Sci Rep ; 10(1): 6059, 2020 04 08.
Artigo em Inglês | MEDLINE | ID: mdl-32269246

RESUMO

Flow of barotropic tidal currents over topographic features, such as continental slopes and submarine ridges, generates internal gravity waves at tidal periods known as internal tides. Amplitude of these waves are generally large near the generation regions. Analysis of Sea Surface Height (SSH) data, derived from satellite altimeter revealed the amplification of internal tides in the semidiurnal period in the north-central Bay of Bengal (BoB) (around 89[Formula: see text]E, 16[Formula: see text]N), which is about 450 km away from their generation sites. SSH signals found in the north-central BoB ([Formula: see text]3 cm) were comparable to the maximum amplitudes (2.5 to 3.5 cm) observed near their potential generation sites in the BoB such as continental slopes in the head of the bay and Andaman-Nicobar (AN) Ridge. Simulations from a high-resolution regional ocean model also confirmed the presence of large internal tide amplitude in the north-central BoB. Our study revealed that convergence of internal tides, which were generated along the concave-shaped source (continental slopes in the head of the bay and the northern parts of AN Ridge), into its focal region caused their amplification in the north-central BoB. It was also found that internal tide energy dissipation rates in this focal region were about 10 times larger than those in other open ocean regions.

16.
Nat Commun ; 10(1): 1257, 2019 03 19.
Artigo em Inglês | MEDLINE | ID: mdl-30890708

RESUMO

Changes in sea level may be attributed either to barotropic (involving the entire water column) or baroclinic processes (governed by stratification). It has been widely accepted that barotropic sea level changes in the tropics are insignificant at intraseasonal time scales (periods of 30-80 days). Based on bottom pressure records, we present evidence for significant basin-wide barotropic sea level variability in the tropical Indian Ocean during December-April with standard deviations amounting to ∼30-60% of the standard deviation in total intraseasonal sea level variability. The origin of this variability is linked to a small patch of wind over the Eastern Indian Ocean, associated with boreal winter Madden-Julian Oscillations (MJO). These large fluctuations are likely to play a prominent role in the intraseasonal sea level and mass budgets. Because of their much faster propagation than baroclinic processes, they allow the basin to adjust to climatic perturbations much more rapidly than was previously thought.

17.
J Chem Phys ; 149(17): 174304, 2018 Nov 07.
Artigo em Inglês | MEDLINE | ID: mdl-30408995

RESUMO

Plasmons in metal nanoparticles (MNPs) promise to enhance solar energy conversion in semiconductors. Two essential mechanisms of enhancement in the near-field regime are hot electron injection (HEI) and plasmon-induced resonance energy transfer (PIRET). Individual studies of both mechanisms indicate that the PIRET efficiency is limited by the short lifetime of the plasmon, whereas the hot electrons result from the plasmon decay. The development of a unified theory of the coupled HEI and PIRET processes is fundamentally interesting and necessary for making reliable predictions but is complicated by the multiple interactions between various components that participate in the enhancement process. In this paper, we use the model-Hamiltonian approach to develop a combined theoretical framework including both PIRET and HEI. The coupled dynamics as well as the time evolution of hot electron energy distribution are studied. The theory further predicts an interference-induced asymmetry in the spectral dependence of PIRET, which can be used to distinguish it from HEI. As the relative contributions of PIRET and HEI strongly depend on the size of the MNPs, this presents itself as a simple route to control the strength of their contributions. The results presented here can further guide future applications of plasmonic solar energy harvesting.

18.
Acta Biomater ; 81: 169-183, 2018 11.
Artigo em Inglês | MEDLINE | ID: mdl-30273744

RESUMO

The development and application of nanofibres requires a thorough understanding of the mechanical properties on a single fibre level including respective modelling tools for precise fibre analysis. This work presents a mechanical and morphological study of poly-l-lactide nanofibres developed by needleless electrospinning. Atomic force microscopy (AFM) and micromechanical testing (MMT) were used to characterise the mechanical response of the fibres within a diameter range of 200-1400 nm. Young's moduli E determined by means of both methods are in sound agreement and show a strong increase for thinner fibres below a critical diameter of 800 nm. Similar increasing trends for yield stress and hardening modulus were measured by MMT. Finite element analyses show that the common practice of modelling three-point bending tests with either double supported or double clamped beams is prone to significant bias in the determined elastic properties, and that the latter is a good approximation only for small diameters. Therefore, an analytical formula based on intermediate boundary conditions is proposed that is valid for the whole tested range of fibre diameters, providing a consistently low error in axial Young's modulus below 10%. The analysis of fibre morphology by differential scanning calorimetry and 2D wide-angle X-ray scattering revealed increasing polymer chains alignment in the amorphous phase and higher crystallinity of fibres for decreasing diameter. The combination of these observations with the mechanical characterisation suggests a linear relationship between Young's modulus and both crystallinity and molecular orientation in the amorphous phase. STATEMENT OF SIGNIFICANCE: Fibrous membranes have rapidly growing use in various applications, each of which comes with specific property requirements. However, the development and production of nanofibre membranes with dedicated mechanical properties is challenging, in particular with techniques suitable for industrial scales such as needleless electrospinning. It is therefore a key step to understand the mechanical and structural characteristics of single nanofibres developed in this process, and to this end, the present work presents changes of internal fibre structure and mechanical properties with diameter, based on dedicated models. Special attention was given to the commonly used models for analyzing Young's modulus of single nanofibers in three-point bending tests, which are shown to be prone to large errors, and an improved robust approach is proposed.


Assuntos
Materiais Biocompatíveis/química , Nanofibras/química , Poliésteres/química , Módulo de Elasticidade
19.
Ann Maxillofac Surg ; 8(1): 73-77, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29963428

RESUMO

CONTEXT: Three-dimensional (3D) locking plates has been designed with the hypothesis that this will overcome the disadvantages of both the systems and also advantages of both systems will be combined for the management of mandibular fractures. AIMS: The purpose of this study was to evaluate the efficacy of 2-mm 3D locking miniplate in the management of anterior mandibular fracture and to compare it with Champy's miniplate. SETTINGS AND DESIGN: A prospective, randomized, clinical trial was carried out in thirty patients who were divided equally in two groups. SUBJECTS AND METHODS: Group I and Group II patients were treated with 2-mm 3D locking plates and 2-mm standard miniplates, respectively. They were evaluated according to the outcomes of the study, that is, working time, wound dehiscence, infection, segmental mobility, postoperative occlusion, need for postoperative intermaxillary fixation (IMF), and radiological evaluation of reduction and fixation. STATISTICAL ANALYSIS USED: Student's t-test and Mann-Whitney test were used to compare the two systems. The data were analyzed using Statistical Package for the Social Science version 14.0. The P value was taken as significant when <0.05 (confidence interval of 95% was taken). RESULTS: The mean duration of procedure for Group I was found to be 49.33 min, whereas for Group II was 59.67 min. There was significantly greater pain on day 1 and at 1 week in Group II patients. 6.7% (n = 1) of both groups showed incidence of infection. Postoperative stability was adequate in most cases except in one patient (n = 1) of 3D locking system, which was revealed as postoperative occlusal disharmony, unsatisfactory radiological reduction of the fracture fragments, and the segmental mobility. There was no incidence of wound dehiscence, tooth damage, and nerve damage in either group. CONCLUSIONS: The result of the study can conclude that there is no major difference between both systems in terms of treatment outcome.

20.
J Chem Phys ; 148(14): 144707, 2018 Apr 14.
Artigo em Inglês | MEDLINE | ID: mdl-29655338

RESUMO

The Landauer expression for computing current-voltage characteristics in nanoscale devices is efficient but not suited to transient phenomena and a time-dependent current because it is applicable only when the charge carriers transition into a steady flux after an external perturbation. In this article, we construct a very general expression for time-dependent current in an electrode-molecule-electrode arrangement. Utilizing a model Hamiltonian (consisting of the subsystem energy levels and their electronic coupling terms), we propagate the Schrödinger wave function equation to numerically compute the time-dependent population in the individual subsystems. The current in each electrode (defined in terms of the rate of change of the corresponding population) has two components, one due to the charges originating from the same electrode and the other due to the charges initially residing at the other electrode. We derive an analytical expression for the first component and illustrate that it agrees reasonably with its numerical counterpart at early times. Exploiting the unitary evolution of a wavefunction, we construct a more general Landauer style formula and illustrate the emergence of Landauer transport from our simulations without the assumption of time-independent charge flow. Our generalized Landauer formula is valid at all times for models beyond the wide-band limit, non-uniform electrode density of states and for time and energy-dependent electronic coupling between the subsystems. Subsequently, we investigate the ingredients in our model that regulate the onset time scale of this steady state. We compare the performance of our general current expression with the Landauer current for time-dependent electronic coupling. Finally, we comment on the applicability of the Landauer formula to compute hot-electron current arising upon plasmon decoherence.

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