Oral Cancer Screening by Artificial Intelligence-Oriented Interpretation of Optical Coherence Tomography Images.

Early diagnosis of oral cancer is critical to improve the survival rate of patients. The current strategies for screening of patients for oral premalignant and malignant lesions unfortunately miss a significant number of involved patients. Optical coherence tomography (OCT) is an optical imaging modality that has been widely investigated in the field of oncology for identification of cancerous entities. Since the interpretation of OCT images requires professional training and OCT images contain information that cannot be inferred visually, artificial intelligence (AI) with trained algorithms has the ability to quantify visually undetectable variations, thus overcoming the barriers that have postponed the involvement of OCT in the process of screening of oral neoplastic lesions. This literature review aimed to highlight the features of precancerous and cancerous oral lesions on OCT images and specify how AI can assist in screening and diagnosis of such pathologies.

In vivo efficacy of 3D-printed elastin-gelatin-hyaluronic acid scaffolds for regeneration of nasal septal cartilage defects.

Nasal septal cartilage perforations occur due to the different pathologies. Limited healing ability of cartilage results in remaining defects and further complications. This study sought to assess the efficacy of elastin-gelatin-hyaluronic acid (EGH) scaffolds for regeneration of nasal septal cartilage defects in rabbits. Defects (4 × 7 mm) were created in the nasal septal cartilage of 24 New Zealand rabbits. They were randomly divided into four groups: Group 1 was the control group with no further intervention, Group 2 received EGH scaffolds implanted in the defects, Group 3 received EGH scaffolds seeded with autologous auricular chondrocytes implanted in the defects, and Group 4 received EGH scaffolds seeded with homologous auricular chondrocytes implanted in the defects. After a 4-month healing period, computed tomography (CT) and magnetic resonance imaging (MRI) scans were obtained from the nasal septal cartilage, followed by histological evaluations of new tissue formation. Maximum regeneration occurred in Group 2, according to CT, and Group 3, according to both T1 and T2 images with 7.68 ± 1.36, 5.44 ± 2.41, and 8.72 ± 3.02 mm2 defect area respectively after healing. The difference in the defect size was statistically significant after healing between the experimental groups. Group 3 showed significantly greater regeneration according to CT scans and T1 and T2 images. The neocartilage formed over the underlying old cartilage with no distinct margin in histological evaluation. The EGH scaffolds have the capability of regeneration of nasal cartilage defects and are able to integrate with the existing cartilage; yet, they present the best results when pre-seeded with autologous chondrocytes.

Upper Airway Changes Following Different Orthognathic Surgeries, Evaluated by Cone Beam Computed Tomography: A Systematic Review and Meta-analysis.

PURPOSE: This study sought to assess the upper airway changes following different orthognathic surgeries using cone-beam computed tomography. METHODS: An electronic search of the literature was conducted in major electronic databases including Medline (PubMed), Web of Science, Scopus, and Open Grey for articles published up to January 20, 2018. Human studies that evaluated the changes in the volume and minimum cross-sectional area of the upper airway or its subdivisions in patients who had undergone orthognathic surgery by use of cone-beam computed tomography were included. Manual search of the bibliographies of the included articles was also conducted. The included studies underwent risk of bias assessment. RESULTS: A total of 1330 articles were retrieved. After excluding the duplicates and irrelevant articles, 41 studies fulfilled the eligibility criteria for this systematic review; out of which, 30 entered the meta-analysis. The majority of studies had a medium risk of bias. Mandibular setback, and maxillary advancement + mandibular setback decreased the volume of the upper airway (-6042.87 mm3 and -1498.78 mm3, respectively) and all its subdivisions in long-term (>3 months), except for the nasopharynx, the volume of which increased following maxillary advancement + mandibular setback. Mandibular advancement and maxillomandibular advancement both increased the upper airway volume in long-term (7559.38 mm3 and 7967.06 mm3, respectively); however, only the changes after the former procedure were significant. The minimum cross-sectional area increased after maxillomandibular advancement (161.43 mm2), and decreased following maxillary advancement + mandibular setback (-23.79 mm2) in long-term. CONCLUSION: There is moderate evidence to suggest that mandibular advancement is the only orthognathic movement that provides a statistically significant change in long-term upper airway volume.

Maxillary osteosarcoma: a case report and review of maxillary sinus space-occupying lesions / Osteossarcoma maxilar: um relato de caso e análise de lesões que ocupam o espaço do seio maxilar

Osteosarcoma is a relatively rare lesion in the maxillary bone. The proximity of the lesion to the maxillary sinus provides a null space with the minimum resistance to progress prior to manifest clinically, which makes the early diagnosis more critical. We report a case of maxillary osteosarcoma in a 21-year old male patient who was presented with the chief complaint of the pain and swelling on the left side of palate since 2 months earlier. A cone-beam computed tomography of the maxilla revealed a diffuse hyper-intense entity at the left side of the maxilla. Totally-occupied maxillary sinus space, asymmetric periodontal ligament widening of the involved teeth and spiculated and sunray periosteal reaction were recognized. The diagnosis of osteosarcoma was established and confirmed by histopathology. This article reviews the sinus-occupying lesion in the following and describes the lesions originate within the maxillary sinus or arise from the adjacent odontogenic components. (AU)

O osteossarcoma é uma lesão relativamente rara no osso maxilar. A proximidade da lesão ao seio maxilar proporciona um espaço vazio com resistência mínima ao progresso da lesão antes de se manifestar clinicamente, o que torna o diagnóstico precoce mais crítico. Relatamos um caso de osteossarcoma maxilar em um paciente do sexo masculino de 21 anos que se apresentou com queixa principal de dor e inchaço do lado esquerdo do palato desde 2 meses antes. Uma tomografia computadorizada Cone Beam da maxila revelou uma entidade hiperintensa difusa do lado esquerdo da maxila. Seio maxilar totalmente ocupado, alargamento assimétrico do ligamento periodontal dos dentes envolvidos e reação periosteal espiculada e em raios de sol foi reconhecida. O diagnóstico de osteossarcoma foi estabelecido e confirmado por histopatologia. Este artigo analisa a lesão que ocupa o seio maxilar e descreve as lesões originadas dentro do seio maxilar ou que surgem de componentes odontogênicos adjacentes (AU)