Thinking in paracoccidioidomycosis: a delayed diagnosis of a neglected tropical disease, case report and review of clinical reports and eco-epidemiologic data from Colombia since the 2000.

BACKGROUND: Paracoccidioidomycosis is a neglected tropical disease, endemic in several countries of South America including Colombia. We report a case of a patient with Chronic Multifocal Paracoccidioidomycosis with long-standing symptoms and a delayed diagnosis caused by several barriers to achieve it. We did a review of the papers published in Colombia about this disease, focusing in clinical data and eco-epidemiology with the finding of a lack of new information on this topic since the 2000 in our region. CASE PRESENTATION: We present a 54-year-old man, farmer in his youth, with a chronic ulcerated lesion in the lower lip similar to a lip carcinoma, a deforming lesion in the nose, and respiratory symptoms with emphysematous lung. Lip biopsy with silver methenamine stain revealed small and large budding yeasts that resembles a "mariner's wheel" confirming Chronic Multifocal Paracoccidioidomycosis. He was treated successfully but subsequently lost to follow up. CONCLUSIONS: It is very important to focus attention, reinforce the search and create networks for the study of neglected tropical diseases. The presented case illustrates a usual clinical presentation, but with a delayed diagnosis due to the difficulties that still occur in some regions like ours for the early recognition of a case of chronic multifocal paracoccidioidomycosis.

Solithromycin for the treatment of community-acquired bacterial pneumonia.

INTRODUCTION: Community-acquired pneumonia is a major public health problem worldwide. In recent years, there has been an increase in the frequency of resistance to the antimicrobials such as ß-lactams or macrolides which have habitually been used against the causative pathogens. Solithromycin, a next-generation macrolide, is the first fluoroketolide with activity against most of the frequently isolated bacteria in community-acquired pneumonia, including typical and atypical bacteria as well as macrolide-resistant Streptococcus pneumoniae. Areas covered: A detailed assessment of the literature relating to the antimicrobial activity, pharmacokinetic/pharmacodynamic properties, efficacy, tolerability and safety of solithromycin for the treatment of community-acquired bacterial pneumonia Expert commentary: Recent randomized controlled phase II/III trials have demonstrated the equivalent efficacy of oral and intravenous solithromycin compared with fluoroquinolones in patients with lower mild-to-moderate respiratory infections, and have shown that systemic adverse events are comparable between solithromycin and alternative treatments. However, studies of larger populations which are able to identify infrequent adverse events are now needed to confirm these findings. On balance, current data supports solithromycin as a promising therapy for empirical treatment in adults with community-acquired bacterial pneumonia.

El Museo de Historia Provincial como templo histórico / The Provincial Museum of History as a historical temple

Esta investigación se realizó en el Museo Provincial de Historia de la ciudad de Pinar de Río, con el objetivo de conocer la trascendencia histórica del Museo de Historia Provincial de Pinar del Río. Se dio a conocer la historia del museo y su importancia en la enseñanza y en el aprendizaje de la misma, específicamente en los estudiantes de medicina de segundo a cuarto año. Como resultados de esta investigación sale a relucir que el museo en la actualidad ha sido poco utilizado, este factor se debe a la poca motivación de los estudiantes y del poco tiempo con que cuentan. En este trabajo haremos una breve reseña de la historia del museo Templo de las Musas...(AU)

This research paper was carried out in the Provincial Museum of History in Pinar del Rio. The history of the museum and its importance to the teaching and learning process of the subject, specifically to the students of medicine enroll in second and fourth academic years. The results of this research brought up that at present the museum is rarely used; this factor was due to the lack of motivation of the medical students to visit the museum and the shortness of time the medical students have. In this paper a brief review is given about the history of the museum (The temple of Muses)...(AU)