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1.
J Opt Soc Am A Opt Image Sci Vis ; 37(5): 748-751, 2020 May 01.
Artigo em Inglês | MEDLINE | ID: mdl-32400705

RESUMO

A band-rejection filter is proposed based on a prism-waveguide cascaded coupling system, which is composed of an equilateral trapezium prism and a deposited multilayer structure. By properly adjusting the thickness of the coupling layer and the light extinction coefficient of the guiding layer, the radiative and intrinsic dampings matching condition could be well satisfied, and then a series of reflectivity dips will appear in the reflectivity wavelength spectrum. Since the module of reflectivity is smaller than one, the extinction ratio of the rejected frequency via the cascaded coupling system is twice as high as that of the single-coupling technology. By narrowing the guiding layer to a micrometer scale, the free spectral range is broad enough to cover the Raman spectrum scattered from the frequently used sample. In addition, the numerically calculated results show that the light in the free spectral range is mostly reflected, with an insertion loss down to 0.45 dB. Compared to previously reported band-rejection filters, it is relatively simple to manufacture our device, which possesses potential applications to help distinguish the Raman signal from the elastic scattering background.

2.
Sci Rep ; 7(1): 3174, 2017 06 09.
Artigo em Inglês | MEDLINE | ID: mdl-28600527

RESUMO

Waveguide based optofluidic resonator features high precision and high sensitivity in real-time fluorescent analysis. We present a novel optofluidic resonator following the hollow-core metal-cladding waveguide structure, which is then used to record the real-time binding process of Fe2+ and Fe3+ with protoporphyrin IX (PpIX) in PBS solution, respectively. The central fluorescent wavelength of compound with Fe2+ is in good accordance with that of the normal hemoglobin, whilst the peaks of the Fe3+ compound match the hemoglobin specimen from sickle-cell disease (SCD) patients. Similar statement holds when we monitor the real-time oxidation processes of these products by injecting oxygen into the optofluidic chip. These observations lead to the speculation that the SCD is caused by replacing the Fe2+ in hemoglobin with Fe3+, which may be insightful in the discovery of new clinical routes to cure this disease.


Assuntos
Anemia Falciforme/sangue , Compostos Férricos/sangue , Protoporfirinas/sangue , Anemia Falciforme/genética , Anemia Falciforme/patologia , Feminino , Hemoglobinas/genética , Hemoglobinas/metabolismo , Humanos , Masculino , Ligação Proteica , Protoporfirinas/genética
3.
Opt Express ; 21(11): 13380-5, 2013 Jun 03.
Artigo em Inglês | MEDLINE | ID: mdl-23736589

RESUMO

A high-sensitivity temperature sensor based on the enhanced Goos-Hänchen effect in a symmetrical metal-cladding waveguide is theoretically proposed and experimentally demonstrated. Owing to the high sensitivity of the ultrahigh-order modes, any minute variation of the refractive index and thickness in the guiding layer induced by the thermo-optic and thermal expansion effects will easily give rise to a dramatic change in the position of the reflected light. In our experiment, a series of Goos-Hänchen shifts are measured at temperatures varying from 50.0 °C to 51.2 °C with a step of 0.2 °C. The sensor exhibits a good linearity and a high resolution of approximately 5×10(-3) °C. Moreover, there is no need to employ any complicated optical equipment and servo techniques, since our transduction scheme is irrelevant to the light source fluctuation.

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