Ultrasound-Assisted Extraction, Optimization, Phytochemical Screening and Analysis of Phenolics from Cycas Zeylanica and Antioxidant Activity Evaluation.

The present study focuses on investigating the phytochemical screening of indigenous species, C. zeylanica, for the first time. The leaf extracts have been prepared using ultrasound-assisted methods to obtain the best extraction results using different time and temperature conditions such as 30, 60, and 90 min. and 30, 40, and 60 °C, respectively. The results have been optimized using response surface methodology. Under the optimal extraction conditions of 60 °C for 43.57 minutes, an extract was produced with a yield of 0.238 g and a high total phenolic content of 181.1965 mg GAE/g. The total phenolic content has been evaluated and the presence of gallic acid has been confirmed through the HPLC technique. The optimal extract (OE) showed excellent antioxidant activity for the DPPH assay, with an IC50 of 3.1 µg/ml. Finally, GC-MS profiling has been done to screen the volatile component of the plant extract.

Why social justice matters: a context for suicide prevention efforts.

Suicide is among the 10 leading causes of death in the US and has the potential to suddenly change many lives. It often occurs when people are disproportionately affected by societal conditions, including inequities, discrimination, oppression, and historical trauma. We posit that a social justice framework can improve suicide prevention efforts when incorporated into existing strategies because it mandates that inequities be addressed. It does so through education, engagement, advocacy, and action, and can be especially effective in states and nations with high suicide rates and entrenched societal inequities.

Ethnic Differences for Public Health Knowledge, Health Advocacy Skills, and Health Information Seeking Among High School Students: Community Agents of Change.

Although adult health advocacy programs have been examined in communities, little is known about integrated adolescent health advocacy programs in high schools. The purpose of this study was to examine the health advocacy program impact and ethnic differences among high school students. Using a cross-sectional study, high school students participating in the school-based program completed evaluation surveys. The program domains included upstream causes of health, community assets, and public health advocacy. Bivariate analyses were conducted to examine ethnic differences for public health knowledge, health advocacy skills, and health information seeking behaviors. Using thematic analysis, open-ended survey item responses were coded to identify themes for students' perceptions of community health. Non-Hispanic (n = 72) and Hispanic high school students (n = 182) in ten classes reported owning smartphones (95%) and laptops (76%). Most students (72%) reported seeking online health information. Non-Hispanic students reported significantly higher health advocacy skills for speaking with the class about health issues, identifying community services, or creating health awareness at school than Hispanic students. Non-Hispanic students were more likely to seek health information from fathers and television than Hispanic students. Hispanic students were more likely to seek health information from hospital or clinic staff than non-Hispanic students. Emergent themes included health advocacy skills, community awareness, and individual and community health changes. High schools benefit from integrating health advocacy programs into the core curriculum. Adolescents gain important skills to improve their individual health and engage in changing community health.

Suicide, Resilience, and Connectedness Across the Lifespan: Lessons From American Indian and Alaska Native Elders.

Rates of suicide and associated costs are high and increasing in the United States. From 1999 through 2014, the age-adjusted suicide rate increased 24%, with the pace of increase being greater since 2006. American Indian and Alaska Native persons have significantly lower rates of suicides than other ethnic groups as elders despite experiencing some of the highest rates during adolescence. This article examines literature pertaining to suicide rates in American Indian and Alaska Native communities and proposes a framework for understanding their lower rates of suicide as elders. Such understanding offers opportunities for developing strategies for suicide prevention across lifespan.

Evaluation of a Promotora-led Intervention on Colorectal Cancer among Hispanics: Findings related to Perceptions and Communications.

We implemented a home-based group educational intervention in the form of home health parties (HHPs) among Hispanic men and women in the Lower Yakima Valley of Washington State led by trained bilingual promotoras and compared participants' baseline and follow-up responses to questions related to communications about CRC screening. We also documented participants perceptions of the CRC related educational information presented as measures of effectiveness of the HHPs as well as possible indicators of their intentions to engage in timely CRC screenings. The group based educational sessions resulted in positive participants' perceptions about the benefits of the CRC related information and in improved communications about CRC screening. Results suggest the benefits of utilizing promotoras' cultural knowledge and awareness to present content about cancers such as CRC in ways that are easily understandable to Hispanic participants and that could result in improved communications and action about cancer screenings.

Improving knowledge and screening for colorectal cancer among Hispanics: overcoming barriers through a PROMOTORA-led home-based educational intervention.

In the U.S., nearly 67 % of Hispanics ages 50 and older report that they have never had a screening colonoscopy. Barriers to screening include cost, lack of health insurance, anticipation of pain, embarrassment, mistrust of medical/healthcare systems and institutions, a fatalistic belief system, as well as fear and lack of knowledge regarding cancer survival. These barriers are significantly more problematic among Hispanics who are poor and those who live in underserved rural and border communities. This study addressed barriers by using promotoras and a home-based educational intervention to improve knowledge of cancer and screening for colorectal cancer (CRC) among Hispanics in Yakima Valley, Washington. Study participants attended a promotora led home-based educational intervention consisting of home-health parties (HHPs) and completed baseline and follow-up surveys on general cancer knowledge and knowledge specific to CRC and related screening practices. Results suggest increase in knowledge of cancer and participation in screening for CRC. Promotora facilitated home-based interventions offer culturally appropriate ways to reach Hispanics in rural and other underserved communities to reduce barriers and improve access to CRC and other cancer screenings.

Clinical comparison of ICD detection algorithms that include rapid-VT zones.

INTRODUCTION: The safe use of antitachycardia pacing (ATP) to terminate rapid ventricular tachycardias (VTs) (cycle length 240-320 ms) is predicated on the ability of implantable cardioverter defibrillators (ICDs) to distinguish rapid VT from ventricular fibrillation (VF). We set out to compare the time to device charging following the induction of VF of various ICD multizone detection algorithms for rapid VT/VF discrimination. METHODS AND RESULTS: Data on the time to device charging following the induction of VF at the time to device implantation were collected on 62 consecutive patients in a nonrandomized prospective cohort fashion. Multizone programming for the Boston Scientific, Medtronic, and St. Jude Medical devices was based on prior clinically validated data. Sixty-two subjects were studied (Boston Scientific = 16, Medtronic = 27, St. Jude Medical = 19) and 124 tests for VF detection were performed (Boston Scientific = 32, Medtronic = 54, St. Jude Medical = 38). Mean time to charging was significantly prolonged in the Boston Scientific group as was the percentage of tests where charge initiation occurred >5 seconds from VF-induction: 4.24, 3.99, and 3.00 seconds and 19%, 4%, and 0% for the Boston Scientific, Medtronic, and St. Jude Medical groups, respectively, P < 0.05. ATP was the first therapy administered in 9.4% of tests in the Boston Scientific group. CONCLUSION: The Boston Scientific multizone VT/VF discrimination algorithm results in a prolonged time to VF detection, and consequently, prolonged time to appropriate initiation of device charging. Further studies are needed to determine whether prolonged detection times lead to clinically significant events.

How much do they know about sexual health?: Knowledge and information-seeking behaviors of Spanish-speaking immigrant adolescents in Curacao, Netherlands Antilles.

Scant HIV/AIDS prevalence data from Curacao suggest that 65.9% of the HIV/AIDS cases in the Netherlands Antilles are currently being documented in this country. The present cross-sectional qualitative study evaluated levels of knowledge of sexual health and information-seeking behavior of Spanish-speaking immigrant adolescents in Curacao. Findings point to a greater need for channels of sexual health information targeting adolescents that focus on the interpersonal aspects of sexuality, to encourage greater parental involvement in their adolescents' lives, and to improve communications between adolescents and their parents. Study findings also suggest the need for a more thoughtful and systematic exploration of the indications by participants that force/coercion specifically by older men including stepfathers was a reason for sexual initiation of many young Latina girls in Curacao.

Grandparents raising grandchildren in a US-Mexico border community.

When parents are unwilling or unable to care for their children, more often than not, grandparents step up to assume this task. Although insights into the multifaceted and unique needs of custodial grandparents are emerging, there is little research on how these changes in living circumstances impact the lives of custodial grandparents and the grandchildren in their care. In this exploratory study, the authors examined the circumstances under which grandparents in a border community assumed custodial care of their grandchildren and the factors that contributed to their decision. Through semi-structured interviews with six grandparents and five grandchildren, they also explored how grandparents and grandchildren coped with transition, how grandparents understood and found meaning in their role as caregivers of their grandchildren, how grandchildren viewed their grandparents in their new role, and how their lives and relationships had changed.