[Interferon efficacy in treating patients with Astrakhan fever]. / Effektivnost' interferonov pri lechenii bol'nykh astrakhanskoi likhoradkoi.

Astrakhan fever is a new endemic rickettsiosis belonging to the group of tick-borne spotted fevers. Adjuvant use of interferons in basic treatment of Astrakhan fever elevates its efficacy. The maximal contribution of interferons can be reached at administration of alpha-2 and gamma-interferons in daily doses 15,000-25,000 and 1500-2500 IU/kg, respectively. The response is higher at early administration of the medication. Interferons induce side effects early in the course: intensification of hyperthermia and pains.

[The primary effect and characteristics of the course of a new tick-borne rickettsiosis--Astrakhan fever]. / Pervichnyi éffekt i osobennosti techeniia novogo kleshchevogo rikketsioza--astrakhanskoi likhoradki.

Clinicomorphological characteristics are given of primary reaction at the site of tick (Rhipicephalus pumilio) bite in new rickettsiosis spreading in Astrakhan Province--Astrakhan fever. The disease presented with long-term fever (body temperature 39-40 degrees C), intoxication, conjunctivitis, hepatomegaly, regional lymphadenitis, disseminated roseolous papular-hemorrhagic rash, arterial hypotension.

[An immunochemical study of the antigenic profile of cultured strains of Treponema pallidum]. / Immunokhimicheskoe izuchenie antigennogo profilia kul'tural'nykh shtammov blednoi treponemy.

Antigenic profile of T. pallidum culture strains was under study. To prove the presence of 'active' antigenic substances with antibodies in the blood sera of syphilitics, the authors have employed immunization with antigen preparation and reimmunization with antigen precipitate from syphilitics' blood sera. Crossed immunoelectrophoresis has detected up to 25 antigenic components in US-treated culture strains. Five of these contributed to the formation of the specific precipitate from syphilitics' blood sera pool.

[The use of immunoenzyme analysis for recording specific IgM antibodies in syphilis patients]. / Primenenie immunofermentnogo analiza dlia registratsii spetsificheskikh IgM-antitel u bol'nykh sifilisom.

Specific IgM antibodies were assayed in blood sera of 230 patients with various forms of syphilis and of 561 controls. Enzyme immunoassay (EIA) sensitivity has made up 95.8 percent for primary syphilis, 93.8 percent for secondary new, 78.3 percent for secondary recurrent, 35.4 percent for early latent, 37.5 percent for late latent, and 80 percent for unknown syphilis. False-positive reactions were recorded in 5.5 percent of cases and were as a rule seen in the sera from patients with diffuse diseases of connective tissue. IgM EIA has proved highly effective in testing the sera from patients with primary seronegative syphilis and from subjects who had sexual intercourse with patients suffering from contagious forms of syphilis.

[The protein-binding properties of Treponema]. / Izuchenie proteinsviazyvaiushchikh svoistv treponemy.

A new type of substances is described, related to T. pallidum cultural strain structure and interacting with human and animal blood serum proteins, named T-PBC. T-PBC were found to react with albumin, immunoglobulins G, M, and A, fibronectin, CIg component of human blood serum complement, goat and bovine blood serum immunoglobulins. When injected to animals, T-PBC induced production of specific antibodies identifying 4 components in T-PBC, 2 of these components being resistant to heating at 100 degrees C for 5 min. All these components could be stained with protein stains.

[The use of "aluminal" stain in dermatology and venereology. I. Indication of protein fractions after disc electrophoresis]. / Primenenie krasitelia "Aliuminon" v dermatovenerologii. Soobshchenie 1. Indikatsiia belkovykh fraktsii posle disk-élektroforeza.

A new method for staining the electrophoregrams is described. After disk electrophoresis the gels are treated in a solution with 0.01-0.02% of aluminol stain, 0.0027-0.0108% of iron chloride (III), and 7% of acetic acid. The method has been employed in examinations of solid basalioma soluble proteins; the transferrin zone fraction has been virtually undetectable on the electrophoregram of this basalioma.