Vasculitis IgA inducida por acenocumarol / IgA vasculitis induced by acenocoumarol

Se presenta el caso de un varón de 73 años con vasculitis IgA tras la administración de acenocumarol, confirmada mediante estudio anatomopatológico. El cuadro cursó con afectación cutánea, articular y renal. La clínica fue más florida con la reintroducción del fármaco y se resolvió por completo al suspenderlo, sin tratamiento de mantenimiento adicional

We present the case of a 73-year-old man with IgA vasculitis after administration of acenocoumarol, confirmed by anatomopathological study. He had cutaneous, joint and renal involvement. With the reintroduction of the drug, the clinical manifestations worsened. They were completely resolved with its suspension, without additional maintenance treatment

IgA vasculitis induced by acenocoumarol. / Vasculitis IgA inducida por acenocumarol.

We present the case of a 73-year-old man with IgA vasculitis after administration of acenocoumarol, confirmed by anatomopathological study. He had cutaneous, joint and renal involvement. With the reintroduction of the drug, the clinical manifestations worsened. They were completely resolved with its suspension, without additional maintenance treatment.

Lesión cutánea y linfangitis en paciente inmunocompetente / Skin lesion and lymphangitis in an immunocompetent patient

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The interplay between natural selection and susceptibility to melanoma on allele 374F of SLC45A2 gene in a South European population.

We aimed to study the selective pressures interacting on SLC45A2 to investigate the interplay between selection and susceptibility to disease. Thus, we enrolled 500 volunteers from a geographically limited population (Basques from the North of Spain) and by resequencing the whole coding region and intron 5 of the 34 most and the 34 least pigmented individuals according to the reflectance distribution, we observed that the polymorphism Leu374Phe (L374F, rs16891982) was statistically associated with skin color variability within this sample. In particular, allele 374F was significantly more frequent among the individuals with lighter skin. Further genotyping an independent set of 558 individuals of a geographically wider population with known ancestry in the Spanish population also revealed that the frequency of L374F was significantly correlated with the incident UV radiation intensity. Selection tests suggest that allele 374F is being positively selected in South Europeans, thus indicating that depigmentation is an adaptive process. Interestingly, by genotyping 119 melanoma samples, we show that this variant is also associated with an increased susceptibility to melanoma in our populations. The ultimate driving force for this adaptation is unknown, but it is compatible with the vitamin D hypothesis. This shows that molecular evolution analysis can be used as a useful technology to predict phenotypic and biomedical consequences in humans.

Dermatitis por calzado / Shoe dermatitis

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Involvement of ANXA5 and ILKAP in susceptibility to malignant melanoma.

Single nucleotide-polymorphisms (SNPs) are a source of diversity among human population, which may be responsible for the different individual susceptibility to diseases and/or response to drugs, among other phenotypic traits. Several low penetrance susceptibility genes associated with malignant melanoma (MM) have been described, including genes related to pigmentation, DNA damage repair and oxidative stress pathways. In the present work, we conducted a candidate gene association study based on proteins and genes whose expression we had detected altered in melanoma cell lines as compared to normal melanocytes. The result was the selection of 88 loci and 384 SNPs, of which 314 fulfilled our quality criteria for a case-control association study. The SNP rs6854854 in ANXA5 was statistically significant after conservative Bonferroni correction when 464 melanoma patients and 400 controls were analyzed in a discovery Phase I. However, this finding could not be replicated in the validation phase, perhaps because the minor allele frequency of SNP rs6854854 varies depending on the geographical region considered. Additionally, a second SNP (rs6431588) located on ILKAP was found to be associated with melanoma after considering a combined set of 1,883 MM cases and 1,358 disease-free controls. The OR was 1.29 (95% CI 1.12-1.48; p-value = 4×10-4). Both SNPs, rs6854854 in ANXA5 and rs6431588 in ILKAP, show population structure, which, assuming that the Spanish population is not significantly structured, suggests a role of these loci on a specific genetic adaptation to different environmental conditions. Furthermore, the biological relevance of these genes in MM is supported by in vitro experiments, which show a decrease in the transcription levels of ANXA5 and ILKAP in melanoma cells compared to normal melanocytes.

Dermatitis alérgica de contacto por propóleo / Allergic contact dermatitis from propolis

El propóleo es un producto elaborado por las abejas a partir de diferentes especies vegetales. Dadas sus propiedades antinflamatorias y antisépticas entre otras, es muy utilizada en productos naturales terapéuticos y cosméticos. A pesar de que inicialmente se considerara una dermatosis profesional, propia de apicultores, hoy en día la mayoría de casos de dermatitis alérgica por propóleo se dan precisamente en usuarios de productos naturistas que contienen propóleo. Presentamos un caso de dermatitis alérgica por una crema natural que contenía propóleo

Bees produce propolis from different vegetal species. As it is said to have anti-infl ammatory and antiseptic properties among many other, we can fi nd it in lots of natural therapeutic and cosmetic products. Although it was fi rst described like a professional dermatosis, nowadays most of the allergic contact dermatitis cases are reported in patients who use this kind of products. A case of allergic contact dermatitis due to a natural topical product is reported