1.
Structure
; 32(5): 520-522, 2024 May 02.
Artigo
em Inglês
| MEDLINE
| ID: mdl-38701750
RESUMO
In a recent issue of Nature Chemical Biology, Folger et al. demonstrated a high-throughput approach for engineering peptide bond forming domains from non-ribosomal peptide synthesis. A non-ribosomal peptide synthetase module from surfactin biosynthesis was reprogrammed to accept a fatty acid substrate into peptide biosynthesis, thus illustrating the potential of this approach for generating novel bioactive peptides.