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1.
Clin Med (Lond) ; 20(6): 593-596, 2020 11.
Artigo em Inglês | MEDLINE | ID: mdl-33199327

RESUMO

Exertional breathlessness and hypoxia are common presenting complaints in acute medicine. We describe a case where the patient continued to have persistent hypoxia even after the primary cause (pulmonary embolism) was diagnosed and treated. The hypoxia persisted as an enigma, its cause remaining elusive till diagnosed. Standard first-line investigations would not have reached the underlying diagnosis in this case and, as such, it demonstrates the keen clinical sense and complex investigative strategy required to solve the puzzle.


Assuntos
Forame Oval Patente , Embolia Pulmonar , Dispneia/etiologia , Humanos , Hipóxia/etiologia
2.
Heart Lung ; 44(6): 481-5, 2015.
Artigo em Inglês | MEDLINE | ID: mdl-26314758

RESUMO

Myocardial edema is one of the characteristic features in the pathogenesis of Takotsubo syndrome. We report a middle aged man who presented with typical clinical and echocardiographic features of apical variant of Takotsubo syndrome. However, a cardiovascular magnetic resonance study performed 10 days after presentation did not show any apical 'ballooning' but revealed features of an apical hypertrophic cardiomyopathy on cine images. Tissue characterization with T2 weighted images proved severe edema as the cause of significantly increased apical wall thickness. A follow-up cardiovascular magnetic resonance study was performed 5 months later which showed that edema, wall thickening and the appearance of apical hypertrophic cardiomyopathy all resolved, confirming Takotsubo syndrome as the cause of the initial appearance. As the affected myocardium most commonly involves the apical segments, an edema induced increase in apical wall thickness may lead to appearances of an apical hypertrophic cardiomyopathy rather than apical ballooning in the acute to subacute phase of Takotsubo syndrome.


Assuntos
Cardiomiopatia Hipertrófica/diagnóstico , Edema/etiologia , Imagem Cinética por Ressonância Magnética/métodos , Miocárdio/patologia , Cardiomiopatia de Takotsubo/complicações , Adulto , Diagnóstico Diferencial , Edema/diagnóstico , Humanos , Masculino , Cardiomiopatia de Takotsubo/diagnóstico
4.
Dermatol Online J ; 14(12): 5, 2008 Dec 15.
Artigo em Inglês | MEDLINE | ID: mdl-19265618

RESUMO

A 73-year-old male patient admitted with erythroderma was diagnosed to have primary systemic Analpastic Lymphoma Kinase (ALK) positive, CD 30 positive, anaplastic large cell lymphoma. The patient's condition deteriorated rapidly during the period after the diagnosis was confirmed, with subsequent death before chemotherapy could be started. He had been started on carbamazepine, for diabetic neuropathy three months prior to the development of the skin lesions. Here we highlight the possibility of carbamazepine inducing anaplastic large cell lymphomas and the need for a high level of suspicion to make an early diagnosis allowing rapid appropriate treatment in such cases.


Assuntos
Carbamazepina/efeitos adversos , Dermatite Esfoliativa/complicações , Linfoma Anaplásico de Células Grandes/diagnóstico , Linfoma Anaplásico de Células Grandes/etiologia , Idoso , Neuropatias Diabéticas/tratamento farmacológico , Progressão da Doença , Evolução Fatal , Humanos , Masculino , Tomografia Computadorizada por Raios X
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