[Circulating immune complexes and immunoglobulins A, M and G in the mother-fetus system in normal pregnancy and gestosis]. / Tsirkuliruiushchie immunnye kompleksy i immunoglobuliny A, M, G v sisteme mat'-plod pri fiziologicheskoi beremennosti i gestoze.

Circulating immune complexes (CIC) and immunoglobulins A, M, and G were measured in the maternal peripheral blood, mixed umbilical blood, and amniotic fluid in women with normal pregnancy and gestosis. CIC concentrations in the examined fluids did not surpass the levels typical of healthy donors. Maternal blood CIC levels were higher in gestosis than in normal pregnancy, and CIC levels in the umbilical blood and amniotic fluid were always lower than in maternal blood serum. IgG levels were found the most shifted. These data evidence changes of the humoral immunity in normal pregnancy, this being, probably, one of the mechanisms providing its favorable course.

[Immunological properties of the amniotic fluid in physiological pregnancy and gestoses]. / Immunologicheskie svoistva okoloplodnoi zhidkosti pri fiziologicheskoi beremennosti i gestozakh.

Immunologic analysis of the amniotic fluid included measurements of immunoglobulins A and M, circulating immune complexes, rheumatoid and antinuclear factors, immunophoresis and electrophoresis, and tests for the presence of donor lymphocytes, Changed immunologic parameters of the amniotic fluid indicate a complicated course of pregnancy, development of gestosis among other things. Basing on their findings, the authors suggest that gestosis involve dysfunction of the adaptive mechanisms, that may result from disordered interactions of the immunity system components.

[Serum trophoblastic beta 1-glycoprotein and alpha fetoprotein levels in physiological pregnancy]. / Soderzhanie trofoblasticheskogo beta1-glicoproteina i alpha- fetoproteina v syvorotke krovi pri fiziologicheski protekaiushchei beremennosti.

Measurements of maternal blood serum trophoblastic beta 1-glycoprotein and alpha-fetoprotein, carried out over the course of normal pregnancy, have demonstrated a progressive increase of trophoblastic beta 1-glycoprotein up to the 36th week, though its level somewhat reduced during the 28th and 32nd weeks. After week 39 the level of this protein in maternal blood serum progressively lowered. alpha-Fetoprotein level was increasing over the course of pregnancy as long as up to the 32nd-34th weeks, then lowering the rest of the term up to delivery. These data permit a conclusion that the time course of the afore-said specific protein concentrations in pregnancy sufficiently well reflects the processes of fetoplacental system establishment and functioning, this permitting the use of these protein measurements in monitoring the course of gestation.