Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 20 de 50
Filtrar
1.
PLoS One ; 19(3): e0287413, 2024.
Artigo em Inglês | MEDLINE | ID: mdl-38483965

RESUMO

As COVID-19 vaccines' accessibility has grown, so has the role of personal choice in vaccination, and not everybody is willing to vaccinate. Exploring personality traits' associations with vaccination could highlight some person-level drivers of, and barriers to, vaccination. We used self- and informant-ratings of the Five-Factor Model domains and their subtraits (a) measured approximately at the time of vaccination with the 100 Nuances of Personality (100NP) item pool (N = 56,575) and (b) measured on average ten years before the pandemic with the NEO Personality Inventory-3 (NEO-PI-3; N = 3,168). We tested individual domains' and either items' (in the 100NP sample) or facets' (in the NEO-PI-3 sample) associations with vaccination, as well as their collective ability to predict vaccination using elastic net models trained and tested in independent sample partitions. Although the NEO-PI-3 domains and facets did not predict vaccination ten years later, the domains correlated with vaccination in the 100NP sample, with vaccinated people scoring slightly higher on neuroticism and agreeableness and lower on openness, controlling for age, sex, and education. Collectively, the five domains predicted vaccination with an accuracy of r = .08. Associations were stronger at the item level. Vaccinated people were, on average, more science-minded, politically liberal, respectful of rules and authority, and anxious but less spiritual, religious, and self-assured. The 100NP items collectively predicted vaccination with r = .31 accuracy. We conclude that unvaccinated people may be a psychologically heterogeneous group and highlight some potential areas for action in vaccination campaigns.


Assuntos
Vacinas contra COVID-19 , COVID-19 , Humanos , COVID-19/prevenção & controle , Personalidade , Inventário de Personalidade , Testes de Personalidade
2.
Emotion ; 24(2): 451-464, 2024 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-37535565

RESUMO

Previous research has associated sleep with subjective well-being (SWB), but less is known about the underlying within-person processes. In the current study, we investigated how self-reported and actigraphy-measured sleep parameters (sleep onset latency, sleep duration, sleep satisfaction, social jetlag, and sleep efficiency) influence SWB (positive affect [PA], negative affect [NA], and life satisfaction [LS]) at the within- and between-person levels. Multilevel analyses of data from 109 university students who completed a 2-week experience sampling study revealed that higher within-person sleep satisfaction was a significant predictor of all three components of next day's SWB (ps < .005). Higher between-person sleep satisfaction was also related to higher levels of PA and LS (ps < .005), whereas shorter self-reported between-person sleep onset latency was associated with higher PA and LS, and lower NA (ps < .05). However, longer actigraphy-measured within-person sleep onset latency was associated with higher next day's LS (p = .028). When including within- and between-person sleep parameters into the same models predicting SWB, only within- and between-person sleep satisfaction remained a significant predictor of all components of SWB. Additionally, we found an effect of higher self-reported within-person sleep onset latency on PA and of shorter self-reported within-person sleep duration on LS (ps < .05). Our results indicate that the evaluative component of sleep-sleep satisfaction-is most consistently linked with SWB. Thus, sleep interventions that are successful in not only altering sleep patterns but also enhancing sleep satisfaction may stand a better chance at improving students' SWB. (PsycInfo Database Record (c) 2024 APA, all rights reserved).


Assuntos
Afeto , Avaliação Momentânea Ecológica , Humanos , Sono , Autorrelato , Estudantes
3.
Front Psychol ; 14: 1077851, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-37057156

RESUMO

Culture-and-personality studies were central to social science in the early 20th century and have recently been revived (as personality-and-culture studies) by trait and cross-cultural psychologists. In this article we comment on conceptual issues, including the nature of traits and the nature of the personality-and-culture relationship, and we describe methodological challenges in understanding associations between features of culture and aspects of personality. We give an overview of research hypothesizing the shaping of personality traits by culture, reviewing studies of indigenous traits, acculturation and sojourner effects, birth cohorts, social role changes, and ideological interventions. We also consider the possibility that aggregate traits affect culture, through psychological means and gene flow. In all these cases we highlight alternative explanations and the need for designs and analyses that strengthen the interpretation of observations. We offer a set of testable hypotheses based on the premises that personality is adequately described by Five-Factor Theory, and that observed differences in aggregate personality traits across cultures are veridical. It is clear that culture has dramatic effects on the thoughts, feelings, and behaviors from which we infer traits, but it is not yet clear whether, how, and in what degree culture shapes traits themselves.

4.
J Pers Assess ; 105(3): 422-435, 2023.
Artigo em Inglês | MEDLINE | ID: mdl-35822872

RESUMO

The Self-Compassion Scale (SCS) is one of the several tools for measuring compassionate self-attitude. Despite its popularity, there is an ongoing controversy regarding its factor structure. Previous studies employing exploratory structural equation modeling (ESEM) found support for the single-bifactor (one general and six group factors) model over the competing two-bifactor (two general factors representing compassionate and uncompassionate self-responding and six group factors) model. Here, we replicated and extended previous ESEM studies through examining the validity and dimensionality of different bifactor models in a sample of UK adults. Model fit was examined across two estimators: maximum likelihood and weighted least square mean and variance adjusted. Finally, we investigated whether one or two observed scores of the SCS can better identify cases of depression, anxiety, and mental wellbeing. Both bifactor models showed good fit to the data irrespective of the estimators used, but only the single-bifactor model demonstrated satisfactory convergent and criterion validity and unidimensionality. The total observed SCS score detected depression, anxiety and high mental wellbeing with higher accuracy than any of the two scores. Overall, we propose to use the total score of the SCS in further research and practice.


Assuntos
Ansiedade , Autocompaixão , Adulto , Humanos , Psicometria , Análise de Classes Latentes , Transtornos de Ansiedade
5.
Emotion ; 23(2): 332-344, 2023 Mar.
Artigo em Inglês | MEDLINE | ID: mdl-35446055

RESUMO

Affect is involved in many psychological phenomena, but a descriptive structure, long sought, has been elusive. Valence and arousal are fundamental, and a key question-the focus of the present study-is the relationship between them. Valence is sometimes thought to be independent of arousal, but, in some studies (representing too few societies in the world) arousal was found to vary with valence. One common finding is that arousal is lowest at neutral valence and increases with both positive and negative valence: a symmetric V-shaped relationship. In the study reported here of self-reported affect during a remembered moment (N = 8,590), we tested the valence-arousal relationship in 33 societies with 25 different languages. The two most common hypotheses in the literature-independence and a symmetric V-shaped relationship-were not supported. With data of all samples pooled, arousal increased with positive but not negative valence. Valence accounted for between 5% (Finland) and 43% (China Beijing) of the variance in arousal. Although there is evidence for a structural relationship between the two, there is also a large amount of variability in this relation. (PsycInfo Database Record (c) 2023 APA, all rights reserved).


Assuntos
Emoções , Idioma , Humanos , Autorrelato , Inquéritos e Questionários , Nível de Alerta
6.
J Pers ; 89(6): 1206-1222, 2021 12.
Artigo em Inglês | MEDLINE | ID: mdl-33998684

RESUMO

INTRODUCTION: Diurnal preferences have been linked to personality but often with mixed results. The present study examines the relationships between sleep timing (chronotype), diurnal preferences, and the Five-Factor Model of personality traits at the phenotypic and genetic level. METHODS: Self- and informant-reports of the NEO Personality Inventory-3, self-reports of the Munich Chronotype Questionnaire, and DNA samples were available for 2,515 Estonian adults (Mage  = 45.76 years; 59% females). Genetic correlations were obtained through summary statistics of genome-wide association studies. RESULTS: Results showed that higher Conscientiousness and lower Openness to Experience were significant predictors of earlier chronotype. At the level of facets, we found that more straightforward (A2) and excitement-seeking (E5), yet less self-disciplined (C5) people were more likely to have later chronotypes. The nuance-level Polypersonality score was correlated with chronotype at r = .28 (p < .001). Conscientiousness and Openness were genetically related with diurnal preferences. The polygenic score for morningness-eveningness significantly predicted the Polypersonality score. CONCLUSION: Phenotypic measures of chronotype and personality showed significant associations at all three of levels of the personality hierarchy. Our findings indicate that the relationship between personality and morningness-eveningness is partly due to genetic factors. Future studies are necessary to further refine the relationship.


Assuntos
Ritmo Circadiano , Estudo de Associação Genômica Ampla , Adulto , Ritmo Circadiano/genética , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Personalidade/genética , Sono/genética , Inquéritos e Questionários
7.
BMC Public Health ; 21(1): 782, 2021 04 23.
Artigo em Inglês | MEDLINE | ID: mdl-33892665

RESUMO

BACKGROUND: This study examined the impact of a 'rewards-for-exercise' mobile application on physical activity, subjective well-being and sleep quality among 148 employees in a UK university with low to moderate physical activity levels. METHODS: A three-month open-label single-arm trial with a one-year follow-up after the end of the trial. Participants used the Sweatcoin application which converted their outdoor steps into a virtual currency used for the purchase of products available at the university campus' outlets, using an in-app marketplace. The primary outcome measure was self-reported physical activity. Secondary measures included device-measured physical activity, subjective well-being (i.e., life satisfaction, positive affect, negative affect), and self-reported sleep quality. RESULTS: The findings show an increase in self-reported physical activity (d = 0.34), life satisfaction (d = 0.31), positive affect (d = 0.29), and sleep quality (d = 0.22) during the three-month trial period. CONCLUSION: The study suggests that mobile incentives-for-exercise applications might increase physical activity levels, positive affect, and sleep quality, at least in the short term. The observed changes were not sustained 12 months after the end of the trial.


Assuntos
Aplicativos Móveis , Exercício Físico , Humanos , Qualidade de Vida , Recompensa , Sono , Universidades
8.
J Biol Rhythms ; 36(2): 169-184, 2021 04.
Artigo em Inglês | MEDLINE | ID: mdl-33353473

RESUMO

People differ in their sleep timings that are often referred to as a chronotype and can be operationalized as mid-sleep (midpoint between sleep onset and wake-up). The aims of the present studies were to examine intraindividual variability and longer-term temporal stability of mid-sleep on free and workdays, while also considering the effect of age. We used data from a 2-week experience sampling study of British university students (Study 1) and from a panel study of Estonian adults who filled in the Munich Chronotype Questionnaire twice up to 5 years apart (Study 2). Results of Study 1 showed that roughly 50% of the variance in daily mid-sleep scores across the 14-day period was attributed to intraindividual variability as indicated by the intraclass correlation coefficient. However, when the effect of free versus workdays was considered, the intraindividual variability in daily mid-sleep across 2 weeks was 0.71 the size of the interindividual variability. In Study 2, mid-sleep on free and workdays showed good levels of temporal stability-the retest correlations of mid-sleep on free and workdays were 0.66 and 0.58 when measured twice over a period of 0-1 to 5 years. The retest stability of mid-sleep scores on both free and workdays sharply increased from young adulthood and reached their peak when participants were in late 40 to early 50 years of age, indicating that age influences the stability of mid-sleep. Future long-term longitudinal studies are necessary to explore how age-related life circumstances and other possible factors may influence the intraindividual variability and temporal stability of mid-sleep.


Assuntos
Ritmo Circadiano , Sono/fisiologia , Adolescente , Adulto , Feminino , Humanos , Individualidade , Estudos Longitudinais , Masculino , Inquéritos e Questionários , Fatores de Tempo , Adulto Jovem
9.
J Child Psychol Psychiatry ; 61(10): 1138-1149, 2020 10.
Artigo em Inglês | MEDLINE | ID: mdl-32924153

RESUMO

BACKGROUND: Findings from primarily cross-sectional studies have linked more extensive social media use to poorer sleep and affective wellbeing among adolescents and young adults. This study examined bedtime social media use, sleep, and affective wellbeing, using an experience sampling methodology with the aim of establishing a day-to-day temporal link between the variables. The study hypothesized a positive association between increased bedtime social media use and lower affective wellbeing the following day, mediated by poorer sleep. METHODS: Using a smartphone application, 101 undergraduate students (Mage  = 19.70 years, SD = 1.09 years), completed daily questionnaires assessing the previous night's bedtime social media use and sleep duration and satisfaction (one measurement per day, questionnaire sent at 08:00), and momentary affective wellbeing (five measurements per day, at randomly varying times between 08:00 and 22:00 on weekdays and 10:00 and 22:00 on weekends), for 14 consecutive days. Objective assessments of total sleep time and sleep efficiency were obtained via wrist-worn actigraphs. By means of separate multilevel models, it was tested whether increased bedtime social media use predicted poorer sleep the same night, whether poorer sleep was predictive of positive and negative affect the following day, and whether sleep mediated the relationship between social media use and affective wellbeing. RESULTS: Increased bedtime social media use was not associated with poorer sleep the same night. Apart from subjective sleep satisfaction, no other sleep variable (i.e., subjective sleep duration, objective total sleep time and objective sleep efficiency) predicted positive or negative affect the following day. CONCLUSIONS: This study found that bedtime social media use is not detrimental to the sleep and affective wellbeing of healthy young adults. However, it is possible that bedtime social media use may be harmful to the sleep of vulnerable individuals.


Assuntos
Avaliação Momentânea Ecológica , Nível de Saúde , Distúrbios do Início e da Manutenção do Sono , Sono , Mídias Sociais/estatística & dados numéricos , Inquéritos e Questionários , Adolescente , Feminino , Humanos , Masculino , Adulto Jovem
10.
Front Res Metr Anal ; 5: 569268, 2020.
Artigo em Inglês | MEDLINE | ID: mdl-33870047

RESUMO

The disciplinary profiles of the mean citation rates across 22 research areas were analyzed for 107 countries/territories that published at least 3,000 papers that exceeded the entrance thresholds for the Essential Science Indicators (ESI; Clarivate Analytics) during the period from January 1, 2009 to December 31, 2019. The matrix of pairwise differences between any two profiles was analyzed with a non-metric multidimensional scaling (MDS) algorithm, which recovered a two-dimensional geometric space describing these differences. These two dimensions, Dim1 and Dim2, described 5,671 pairwise differences between countries' disciplinary profiles with a sufficient accuracy (stress = 0.098). A significant correlation (r = 0.81, N = 107, p < 0.0001) was found between Dim1 and the Indicator of a Nation's Scientific Impact (INSI), which was computed as a composite of the average and the top citation rates. The scientific impact ranking of countries derived from the pairwise differences between disciplinary profiles seems to be more accurate and realistic compared with more traditional citation indices.

11.
Obes Rev ; 20(8): 1121-1131, 2019 08.
Artigo em Inglês | MEDLINE | ID: mdl-30985072

RESUMO

Obesity has inconsistent associations with broad personality domains, possibly because the links pertain to only some facets of these domains. Collating published and unpublished studies (N = 14 848), we meta-analysed the associations between body mass index (BMI) and Five-Factor Model personality domains as well as 30 Five-Factor Model personality facets. At the domain level, BMI had a positive association with Neuroticism and a negative association with Conscientiousness domains. At the facet level, we found associations between BMI and 15 facets from all five personality domains, with only some Neuroticism and Conscientiousness facets among them. Certain personality-BMI associations were moderated by sample properties, such as proportions of women or participants with obesity; these moderation effects were replicated in the individual-level analysis. Finally, facet-based personality "risk" scores accounted for 2.3% of variance in BMI in a separate sample of individuals (N = 3569), 409% more than domain-based scores. Taken together, personality-BMI associations are facet specific, and delineating them may help to explain obesity-related behaviours and inform intervention designs. Preprint and data are available at https://psyarxiv.com/z35vn/.


Assuntos
Obesidade/psicologia , Personalidade , Índice de Massa Corporal , Humanos , Obesidade/etiologia
12.
J Pers ; 87(4): 813-826, 2019 08.
Artigo em Inglês | MEDLINE | ID: mdl-30244473

RESUMO

OBJECTIVE: We tested predictions about the structure and magnitude of method biases in single-source personality trait assessments. We expected a large number of distinct biases that would parallel the observed structure of traits, at both facet and item levels. METHOD: We analyzed multimethod ratings on the Estonian NEO Personality Inventory-3 in a sample of 3,214 adults. By subtracting informant ratings from self-reports, we eliminated true score variance and analyzed the size and structure of the residual method biases. We replicated analyses using data (N = 709) from the Czech Revised NEO Personality Inventory. RESULTS: The magnitude of method biases was consistent with predictions by McCrae (2018, Psychological Assessment). Factor analyses at the facet level showed a clear replication of the normative Five-Factor Model structure in both samples. Item factor analyses within domains showed that facet-level method biases mimicked the facet structure of the instrument. CONCLUSIONS: Method biases apparently reflect implicit personality theory (IPT)-beliefs about how traits and trait indicators covary. We discuss the (collective) accuracy and possible origins of IPT. Because method biases limit the accuracy of single-source assessments, we recommend assessments that combine information from two or more informants.


Assuntos
Determinação da Personalidade/normas , Inventário de Personalidade/normas , Personalidade , Autorrelato/normas , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Comparação Transcultural , República Tcheca , Estônia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Teoria Psicológica , Adulto Jovem
13.
BMJ Open ; 8(7): e022428, 2018 07 10.
Artigo em Inglês | MEDLINE | ID: mdl-29991635

RESUMO

OBJECTIVE: To examine the role of the Five Factor Model (FFM) personality traits in reporting the development of adverse drug reactions (ADRs) when controlling for sociodemographic variables and health status. DESIGN: Prospective cohort study. SETTING: The Estonian Biobank of the Estonian Genome Centre, University of Tartu. PARTICIPANTS: 814 women and 543 men (mean age=47.9 years; SD=15.2) who after the initial enrolment in the Estonian Biobank were re-contacted for follow-up purposes about 5.3 years after the enrolment and for whom both self- and informant-reported personality data were available. MAIN OUTCOME MEASURE: Participants who did not report having any ADRs at baseline but who reported ADRs at the follow-up about 5.3 years later versus participants who did not report any ADRs at either time point. The reports of developing ADRs were predicted from the FFM personality traits after statistically controlling for sociodemographic variables (age, gender and education), baseline indicators of health status (number of diagnoses and medicines taken, body mass index and blood pressure), and the change in health status between the two measurements. RESULTS: The results of a hierarchical binary logistic regression analysis showed that participants who reported the development of ADRs between the two measurements had higher levels of conscientiousness, were more likely to be women, were taking more medicines at baseline and had a higher increase in the number of medicines taken during the study period than participants who did not report any ADRs at either time point (all p values <0.05). Higher neuroticism (p=0.067) and a higher number of diagnosed diseases at baseline (p=0.053) also made marginal contributions to predicting the development of ADRs. CONCLUSIONS: This study shows for the first time that higher levels of conscientiousness and neuroticism are associated with reporting the development of ADRs.


Assuntos
Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/epidemiologia , Personalidade , Autorrelato , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Estudos de Coortes , Efeitos Colaterais e Reações Adversas Relacionados a Medicamentos/psicologia , Estônia/epidemiologia , Feminino , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Neuroticismo , Estudos Prospectivos , Adulto Jovem
14.
Front Psychol ; 9: 187, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29515499

RESUMO

It is widely accepted that the Five Factor Model (FFM) is a satisfactory description of the pattern of covariations among personality traits, which supposedly fits, more or less adequately, every individual. As an amendment to the FFM, we propose that the customary five-factor structure is only a near-universal, because it does not fit all individuals but only a large majority of them. Evidences reveal a small minority of participants who have an unusual configuration of personality traits, which is clearly recognizable, both in self- and observer-ratings. We identified three types of atypical configurations of personality traits, characterized mainly by a scatter of subscale scores within each of the FFM factors. How different configurations of personality traits are formed, persist, and function needs further investigation.

15.
Front Psychol ; 9: 123, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-29479333

RESUMO

The main aim of the current study was to examine the role of co-occurring emotions and their interactive effects with the Big Five personality traits in anger expression. Everyday anger expression ("anger-in" and "anger-out" behavior) was studied with the experience-sampling method in a group of 110 participants for 14 consecutive days on 7 random occasions per day. Our results showed that the simultaneously co-occurring emotions that buffer against anger expression are sadness, surprise, disgust, disappointment, and irritation for anger-in behavior, and fear, sadness and disappointment for anger-out reactions. While previous studies have shown that differentiating one's current affect into discrete emotion categories buffers against anger expression (Pond et al., 2012), our study further demonstrated the existence of specific interactive effects between the experience of momentary emotions and personality traits that lead to higher levels of either suppression or expression of anger behavior (or both). For example, the interaction between the trait Openness and co-occurring surprise, in predicting anger-in behavior, indicates that less open people hold their anger back more, and more open people use less anger-in behavior. Co-occurring disgust increases anger-out reactions in people low in Conscientiousness, but decreases anger-out reactions in people high in Conscientiousness. People high in Neuroticism are less likely to engage in anger-in behavior when experiencing disgust, surprise, or irritation alongside anger, but show more anger out in the case of co-occurring contempt. The results of the current study help to further clarify the interactions between the basic personality traits and the experience of momentary co-occurring emotions in determining anger behavior.

16.
Psychol Sci ; 28(11): 1631-1639, 2017 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-28910230

RESUMO

Heritable variance in psychological traits may reflect genetic and biological processes that are not necessarily specific to these particular traits but pertain to a broader range of phenotypes. We tested the possibility that the personality domains of the five-factor model and their 30 facets, as rated by people themselves and their knowledgeable informants, reflect polygenic influences that have been previously associated with educational attainment. In a sample of more than 3,000 adult Estonians, education polygenic scores (EPSs), which are interpretable as estimates of molecular-genetic propensity for education, were correlated with various personality traits, particularly from the neuroticism and openness domains. The correlations of personality traits with phenotypic educational attainment closely mirrored their correlations with EPS. Moreover, EPS predicted an aggregate personality trait tailored to capture the maximum amount of variance in educational attainment almost as strongly as it predicted the attainment itself. We discuss possible interpretations and implications of these findings.


Assuntos
Escolaridade , Pleiotropia Genética , Herança Multifatorial , Personalidade/genética , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
17.
J Pers ; 85(6): 906-919, 2017 12.
Artigo em Inglês | MEDLINE | ID: mdl-27977872

RESUMO

OBJECTIVE: Our study aims to estimate the proportion of the phenotypic variance of Neuroticism and its facet scales that can be attributed to common single-nucleotide polymorphisms (SNPs) in two adult populations from Estonia (EGCUT; N = 3,292) and the Netherlands (Lifelines; N = 13,383). METHOD: Genomic-relatedness-matrix restricted maximum likelihood (GREML) using genome-wide complex trait analysis (GCTA) software was employed. To build upon previous research, we used self- and informant reports of the 30-facet NEO personality inventories and analyzed both the usual sum scores and the residual facet scores of Neuroticism. RESULTS: In the EGCUT cohort, the proportion of phenotypic variance explained by the additive effects of common genetic variants in self- and informant-reported Neuroticism domain scores was 15.2% (p = .070, SE = .11) and 6.2% (p = .293, SE = .12), respectively. The SNP-based heritability estimates at the level of Neuroticism facet scales differed greatly across cohorts and modes of measurement but were generally higher (a) for self- than for informant reports, and (b) for sum than for residual scores. CONCLUSIONS: Our findings indicate that a large proportion of the heritability of Neuroticism is not captured by additive genetic effects of common SNPs, with some evidence for Gene × Environment interaction across cohorts.


Assuntos
Interação Gene-Ambiente , Neuroticismo , Personalidade/genética , Polimorfismo de Nucleotídeo Único , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Bancos de Espécimes Biológicos , Estônia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Países Baixos , Fenótipo , Adulto Jovem
20.
Nat Genet ; 48(6): 624-33, 2016 06.
Artigo em Inglês | MEDLINE | ID: mdl-27089181

RESUMO

Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive symptoms (n = 161,460), and neuroticism (n = 170,911). We identify 3 variants associated with subjective well-being, 2 variants associated with depressive symptoms, and 11 variants associated with neuroticism, including 2 inversion polymorphisms. The two loci associated with depressive symptoms replicate in an independent depression sample. Joint analyses that exploit the high genetic correlations between the phenotypes (|ρ^| ≈ 0.8) strengthen the overall credibility of the findings and allow us to identify additional variants. Across our phenotypes, loci regulating expression in central nervous system and adrenal or pancreas tissues are strongly enriched for association.


Assuntos
Transtornos de Ansiedade/genética , Depressão/genética , Estudo de Associação Genômica Ampla , Polimorfismo de Nucleotídeo Único , Teorema de Bayes , Humanos , Neuroticismo , Fenótipo
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...