Comparison of Frequency of Congenitally Missing Upper Lateral Incisors among Skeletal Class I, II and III Malocclusions.

AIM: The present investigation aims to find out the frequency of congenitally missing upper lateral incisors among skeletal class I, II, and III malocclusions and to find out its variability among different genders. MATERIALS AND METHODS: The study sample included orthopantomograms (OPGs) and a lateral cephalogram of 1,000 patients retrieved from previous records. Of the selected samples, 290 were males and 710 were females. Orthopantomograms helped diagnose the presence of unilateral/bilateral maxillary lateral incisors. Results and statistics: Of the 1,000 samples, 710 (71%) were female and 290 (29%) were male patients. An estimated 37 (3.77%) patients were found to have missing maxillary lateral incisors. Of the female patients, 4.04% were having missing laterals, whereas 3.10% of the male patients were having agenesis of maxillary incisors. Totally, 0.9% of missing upper laterals were recorded in males, whereas 2.8% of missing lateral incisors in upper arch were found in females. A total of 54.16% of skeletal class I, 33.33% of skeletal class II, and 12.5% of skeletal class III cases were found to have missing upper lateral incisors. CONCLUSION: The prevalence rate for congenitally missing upper lateral incisors in orthodontic adolescent Odia population in Bhubaneswar is 3.77%. The females had a greater percentage of agenesis of the upper lateral incisor when compared to males. An estimated 54.16% of skeletal class I, 33.33% of skeletal class II, and 12.5% of skeletal class III cases were found to have missing upper lateral incisors. This difference might be due to genetic variations or different environmental conditions. A multidisciplinary treatment protocol must be planned to manage the missing maxillary lateral incisor and to restore the impaired esthetics and function.

A Cone-beam Computed Tomography Interpretation of Malar Bone Changes in Skeletal Malocclusion.

AIM: The purpose of this cross-sectional study is to signify malar bone anatomy and to obtain linear correlation with varied skeletal pattern by utilizing cone beam computed tomographic views. MATERIALS AND METHODS: The experimental sample consisted of cone-beam computed tomography (CBCT) scans of 30 patients taken for the purpose of orthodontic treatment and peri implant planning (16 males and 14 females), 11-30 years of age (mean, 23.4 years). The sex and age were documented for all samples and nine landmarks were evaluated. The various CBCT were categorized into different malocclusions based on wits appraisal. Its prevalence was collated with age, sex and various malocclusion by Chi-square test. RESULTS: Age and gender altogether influenced M1. The mean posterior zygomatic bone width (M1) for all sample was 63.7 mm. For M1 estimations, no huge contrast was observed among left and right side (p = 0.915). The mean anteriorzygomatic bone width (M2) was 51.8 mm. No noteworthy contrast amongst two sides (p = 0.995) or age (p = 0.067) was seen. Although sex altogether influenced M3 variety (p = 0.003), the mean greatest cortical thickness (max CT) (M4) was 9.36 mm, significant difference was observed between the minimum cortical thickness of skeletal class I and skeletal class III malocclusion design. CONCLUSION: Detailed evaluation of malar bone should be performed prior to any ortho-surgical procedure using CBCT. CLINICAL SIGNIFICANCE: Our study signifies the importance of consideration of zygoma during any pre-treatment evaluation of skeletal malocclusion. It also marks the pivotal role of zygoma while considering gross facial esthetics. Precise assurance of zygomatic bone size may likewise aid the choice of fitting surgeries and determination of zygomatic implant area. How to cite this article: Dash BP, Reddy R, Mohanty P, et al. A Cone-beam Computed Tomography Interpretation of Malar Bone Changes in Skeletal Malocclusion. J Contemp Dent Pract 2019;20(11):1319-1322.

Epoxyeicosatrienoic acid analog attenuates the development of malignant hypertension, but does not reverse it once established: a study in Cyp1a1-Ren-2 transgenic rats.

OBJECTIVE: We evaluated the therapeutic effectiveness of a new, orally active epoxyeicosatrienoic acid analog (EET-A) in rats with angiotensin II (ANG II)-dependent malignant hypertension. METHODS: Malignant hypertension was induced in Cyp1a1-Ren-2 transgenic rats by activation of the renin gene using indole-3-carbinol (I3C), a natural xenobiotic. EET-A treatment was started either simultaneously with I3C induction process (early treatment) or 10 days later during established hypertension (late treatment). Blood pressure (BP) (radiotelemetry), indices of renal and cardiac injury, and plasma and kidney levels of the components of the renin-angiotensin system (RAS) were determined. RESULTS: In I3C-induced hypertensive rats, early EET-A treatment attenuated BP increase (to 175 ±â€Š3 versus 193 ±â€Š4 mmHg, P < 0.05, on day 13), reduced albuminuria (15 ±â€Š1 versus 28 ±â€Š2 mg/24 h, P < 0.05), and cardiac hypertrophy as compared with untreated I3C-induced rats. This was associated with suppression of plasma and kidney ANG II levels (48 ±â€Š6 versus 106 ±â€Š9 and 122 ±â€Š19 versus 346 ±â€Š11 fmol ml or g, respectively, P < 0.05) and increases in plasma and kidney angiotensin (1-7) concentrations (84 ±â€Š9 versus 37 ±â€Š6 and 199 ±â€Š12 versus 68 ±â€Š9 fmol/ml or g, respectively, P < 0.05). Remarkably, late EET-A treatment did not lower BP or improve renal and cardiac injury; indices of RAS activity were not affected. CONCLUSION: The new, orally active EET-A attenuated the development of experimental ANG II-dependent malignant hypertension, likely via suppression of the hypertensiogenic axis and augmentation of the vasodilatory/natriuretic axis of RAS.

Interlobular Arteries From 2-Kidney, 1-Clip Goldblatt Hypertensive Rats' Exhibit-Impaired Vasodilator Response to Epoxyeicosatrienoic Acids.

BACKGROUND: Small renal arteries have a significant role in the regulation of renal hemodynamics and blood pressure (BP). To study potential changes in the regulation of vascular function in hypertension, we examined renal vasodilatory responses of small arteries from nonclipped kidneys of the 2-kidney, 1-clip Goldblatt hypertensive rats to native epoxyeicosatrienoic acids (EETs) that are believed to be involved in the regulation of renal vascular function and BP. A total of 2 newly synthesized EET analogues were also examined. MATERIALS AND METHODS: Renal interlobular arteries isolated from the nonclipped kidneys on day 28 after clipping were preconstricted with phenylephrine, pressurized and the effects of a 14,15-EET analogue, native 14,15-EET and 11,12-ether-EET-8ZE, an analogue of 11,12-EET, on the vascular diameter were determined and compared to the responses of arteries from the kidneys of sham-operated rats. RESULTS: In the arteries from nonclipped kidneys isolated in the maintenance phase of Goldblatt hypertension, the maximal vasodilatory response to 14,15-EET analogue was 30.1 ± 2.8% versus 49.8 ± 7.2% in sham-operated rats; the respective values for 11,12-ther-EET-8ZE were 31.4 ± 6.4% versus 80.4 ± 6%, and for native EETs they were 41.7 ± 6.6% versus 62.8 ± 4.4% (P ≤ 0.05 for each difference). CONCLUSIONS: We propose that reduced vasodilatory action and decreased intrarenal bioavailability of EETs combined with intrarenal angiotensin II levels that are inappropriately high for hypertensive rats underlie functional derangements of the nonclipped kidneys of 2-kidney, 1-clip Goldblatt hypertensive rats. These derangements could play an important role in pathophysiology of sustained BP elevation observed in this animal model of human renovascular hypertension.

Comparison between efficacy of four different types of orthodontic separators.

AIM: To evaluate the rapidity and amount of separation of four different types of separators (i.e. Elastomeric separators, Dumbbell separators, Kesling springs and NEET springs) and also the percentage of loss of these separators. MATERIALS AND METHODS: The separating effect of 4 different types of separators (i.e. Elastomeric separators, Dumbbell separators, Kesling springs and NEET springs) were assessed for 3 days, and the separated space between molars and premolars were noted separately for three consecutive days. The number and types of lost separators were recorded at the same time. The amount of separation between molars and 2(nd) premolar in each quadrant was measured separately with a leaf gauge (sensitivity 5/100mm) and noted on each day. RESULTS: Dumbbell separators proved to be the fastest in producing separation and they produced consistently greater amount of separation on all three days. CONCLUSIONS: The Dumbbell separator would be ideal for situations where in rapid separation is needed, and also in cases where in the patient comes with the loss of separators.