Reconstructing the history of helminth prevalence in the UK.

Intestinal helminth parasites (worms) have afflicted humans throughout history and their eggs are readily detected in archaeological deposits including at locations where intestinal parasites are no longer considered endemic (e.g. the UK). Parasites provide valuable archaeological insights into historical health, sanitation, hygiene, dietary and culinary practices, as well as other factors. Differences in the prevalence of helminths over time may help us understand factors that affected the rate of infection of these parasites in past populations. While communal deposits often contain relatively high numbers of parasite eggs, these cannot be used to calculate prevalence rates, which are a key epidemiological measure of infection. The prevalence of intestinal helminths was investigated through time in England, based on analysis of 464 human burials from 17 sites, dating from the Prehistoric to Industrial periods. Eggs from two faecal-oral transmitted nematodes (Ascaris sp. and Trichuris sp.) and the food-derived cestodes (Taenia spp. and Diphyllobothrium latum syn Dibothriocephalus latus) were identified, although only Ascaris was detected at a high frequency. The changing prevalence of nematode infections can be attributed to changes in effective sanitation or other factors that affect these faecal-oral transmitted parasites and the presence of cestode infections reflect dietary and culinary preferences. These results indicate that the impact of helminth infections on past populations varied over time, and that some locations witnessed a dramatic reduction in parasite prevalence during the industrial era (18th-19th century), whereas other locations continued to experience high prevalence levels. The factors underlying these reductions and the variation in prevalence provide a key historical context for modern anthelmintic programs.

Epidemiological insights from a large-scale investigation of intestinal helminths in Medieval Europe.

Helminth infections are among the World Health Organization's top neglected diseases with significant impact in many Less Economically Developed Countries. Despite no longer being endemic in Europe, the widespread presence of helminth eggs in archaeological deposits indicates that helminths represented a considerable burden in past European populations. Prevalence of infection is a key epidemiological feature that would influence the elimination of endemic intestinal helminths, for example, low prevalence rates may have made it easier to eliminate these infections in Europe without the use of modern anthelminthic drugs. To determine historical prevalence rates we analysed 589 grave samples from 7 European sites dated between 680 and 1700 CE, identifying two soil transmitted nematodes (Ascaris spp. and Trichuris trichiura) at all locations, and two food derived cestodes (Diphyllobothrium latum and Taenia spp.) at 4 sites. The rates of nematode infection in the medieval populations (1.5 to 25.6% for T. trichiura; 9.3-42.9% for Ascaris spp.) were comparable to those reported within modern endemically infected populations. There was some evidence of higher levels of nematode infection in younger individuals but not at all sites. The genetic diversity of T. trichiura ITS-1 in single graves was variable but much lower than with communal medieval latrine deposits. The prevalence of food derived cestodes was much lower (1.0-9.9%) than the prevalence of nematodes. Interestingly, sites that contained Taenia spp. eggs also contained D. latum which may reflect local culinary practices. These data demonstrate the importance of helminth infections in Medieval Europe and provide a baseline for studies on the epidemiology of infection in historical and modern contexts. Since the prevalence of medieval STH infections mirror those in modern endemic countries the factors affecting STH decline in Europe may also inform modern intervention campaigns.

Single Parasternal-Long-Axis-View-Sweep Screening Echocardiographic Protocol to Detect Rheumatic Heart Disease: A Prospective Study of Diagnostic Accuracy.

BACKGROUND: Echocardiographic screening in school-aged children can detect rheumatic heart disease (RHD) prior to the manifestation of symptoms of heart failure. The challenge is making this practical and affordable on a global scale. This study aims to evaluate the diagnostic utility of an ultra-abbreviated echocardiographic screening protocol involving a single parasternal-long-axis-view-sweep of the heart (SPLASH) in two dimensional (2D) and colour Doppler imaging (index test). METHODS: This prospective study of diagnostic accuracy compared the diagnostic utility of the index screening test with a comprehensive reference test (standard echocardiographic screening protocols) as per World Heart Federation (WHF) echocardiographic criteria. School students in Timor-Leste aged 5-20 years were enrolled. Both index and reference test images were acquired by cardiologists on Vivid I or Q machines (GE Healthcare, Marlborough, MA, USA). RESULTS: A total of 1,365 participants were screened; median age was 11 years. The estimated prevalence of definite and borderline RHD was 35.2 per 1,000. Congenital heart disease was identified in 11 children (0.8%) with two needing cardiac surgery. Abnormal SPLASH views were found in 109/1365 (7.99%). No cases of RHD or significant congenital heart disease were missed. Sensitivity and specificity of the abbreviated protocol for detecting RHD were 1.0 and 0.95 respectively. CONCLUSIONS: A simplified echocardiography screening protocol using SPLASH is highly sensitive and specific and could significantly improve the efficiency of RHD screening. It has the potential to expedite training of health workers whilst protecting the modesty of students.

Case Report: Fatal Pediatric Melioidosis Despite Optimal Intensive Care.

With prompt administration of appropriate antimicrobial therapy and access to modern intensive care support, fatal pediatric melioidosis is very unusual. We describe cases of two children in whom the possibility of melioidosis was recognized relatively early, but who died of the disease, despite receiving optimal supportive care. We discuss the resulting implications for bacterial virulence factors in disease pathogenesis.

High prevalence of rheumatic heart disease in Fiji detected by echocardiography screening.

AIM: Rheumatic heart disease poses a huge burden for developing countries, with Pacific Island nations having among the highest prevalence reported in the world. It is recognised that echocardiography is much more sensitive than clinical examination for detection of rheumatic heart disease, but resource and cost limitations are delaying implementation of screening programmes in developing nations. Rapid echocardiography using low-cost portable machines and a non-expert operator may be a useful compromise, allowing widespread screening and control of rheumatic heart disease in developing countries. METHODS: In-school echocardiography and clinical examination was carried out on primary school children (aged five to 14) in Lautoka, Fiji. All of the children with abnormal findings were then recalled for complete in-hospital clinical and echocardiographic assessment by a paediatrician with expertise in rheumatic heart disease and echocardiography. RESULTS: Using screening echocardiography averaging less than 4 min per patient, the prevalence of definite rheumatic heart disease detected by echocardiogram screening was 55.2 per 1000 compared with 11 per 1000 detected by clinical examination (P < 0.001). It was demonstrated that echocardiography is five times more sensitive at detecting rheumatic heart disease compared with clinical examination. A comprehensive screening programme is estimated to cost less than US$40 per patient detected. CONCLUSION: This study confirms that Fiji has the highest documented prevalence of rheumatic heart disease in the world. Rapid echocardiography has the potential to screen large numbers of patients by non-specialist operators, which encourages its use in larger scale screening and prevention strategies in developing countries.

The use of computer software for planning care in a resource-scarce setting.

Even in the best resourced units, certain situations (e.g. resuscitations) can benefit from anticipation and preplanning. A resource-scarce environment can indirectly lead to poor planning and organization. Here we share our experience of using computer software (Microsoft Office Excel) to improve the planning of patient care. This technology is now widely available and we suggest that it is feasible and, indeed, particularly valuable in a resource-poor setting. We focus on the steps taken to minimize the chances of errors rooted in the program.

Fijian seasonal scourge of mango tree falls.

BACKGROUND: Mango tree falls are a frequent presentation at any health facility in the South Pacific. This study aims to identify (i) the number of admissions because of falls from mango trees; (ii) epidemiology; (iii) seasonal trend; (iv) injury profile; and (v) hospital care provided. METHODS: Retrospective case review on all mango tree falls related injuries resulting in admissions at the Lautoka Hospital, Fiji during a 1-year period (2007). Patient records were analysed to identify specific injury patterns such as upper/lower limb fractures, spinal cord injury and head injury, caused by mango tree falls. RESULTS: Thirty-nine cases were identified. Eighty-two percent (n = 32) of the falls occurred in the mango season (June-November). Seventy-two percent (n = 28) of the patients were males and 28% (n = 11) were females. Seventy-six percent were aged 5-13 and only 21% were adults. Also, 77% (n = 30) of the patients were ethnic Fijians and 23% (n = 9) were Fijian-Indians. Sixty-four percent (n = 25) had closed fractures and 17% (n = 7) had open fractures. Fifty-six percent (n = 22) of the fractures were of the fore arm. There were two cases of spinal cord injury, four cases of head injury, one ICU admission and one death. Average hospital stay was 7.56 days. CONCLUSION: All these injuries were recreational and the majority in the urban setting. They were all avoidable.