Prevalence and clinical characteristics of hyperuricemia among patients with chronic kidney disease under haemodialysis in a tertiary care center: a cross-sectional study.

Background: Hyperuricemia is common in chronic kidney disease patients. This study aimed to investigate the prevalence and clinical characteristics of hyperuricemia in patients with chronic kidney disease undergoing haemodialysis. Materials and methods: This cross-sectional study was conducted among 104 patients with chronic kidney disease who visited the haemodialysis unit of a tertiary centre hospital from 11 September 2022, to 11 November 2022. A convenience sampling technique was used. The data were collected using a proforma form, entered into, and analyzed using the Statistical Package for Social Sciences version 21. Results: The mean age group of the study participants was 54.02 ± 14.03 years, and around two-thirds were male (n=70, 67.3%). Almost half of the participants (50, 48.07%) had hyperuricemia with a mean uric acid level of 6.76 ± 2.62 mg/dl. The majority of the participants had associated hypertension (n=100, 96.2%). More than three-fourths of the respondents (83, 79.8%) had haemoglobin levels below the target range. Conclusion: Nearly half of the study participants had hyperuricemia.

Aluminum Phosphide Poisoning, an Institutional Experience: Case Series.

BACKGROUND: The growing concern over pesticide use has been linked to self-harm and suicide especially in agricultural countries like Nepal.  Pesticides like organophosphorus and aluminum phosphide cause the majority of deaths. Although organophosphorus poisoning is common means for suicide, Aluminum phosphide poisoning is also encountered occasionally. Our case series aims to look after the intent of poisoning and the outcome of the patients following Aluminum phosphide poisoning. METHODS: This hospital record-based study includes Aluminum phosphide poisoning patients presenting to the emergency department of Scheer Memorial Adventist Hospital from first January 2017 to 31st December 2020. Data were analyzed using SPSS version-22. RESULTS:   Out of 25 total poisoning cases, most of them were female (60%) and married (56%).  The case fatality rate was 84% among which 20% cases were brought dead while 64% died in the hospital. All poisoning cases were suicidal in intent. CONCLUSIONS: Herein we report a case series on 25 Aluminum phosphide poisoning cases with high case fatality rate and all cases being suicidal in intent.

Psychological and clinical-epidemiological profile of poisoning in Nepal: an institutional experience.

Background  Poisoning has become a major public health problem, with the intent in most cases being self-harm and commit suicide. This study highlights the psychological and clinical-epidemiological profile of patients visiting Scheer Memorial Adventist Hospital after poisoning.  Methods  This retrospective record-based study was done among poisoning patients of a hospital in Nepal from 1st January 2018 to 31st December 2020. Data were analyzed using STATA version-15.  Results  Out of 134 total poisoning cases, 71 had consumed organophosphate compounds. The majority of the cases were female (59.2% in organophosphate groups, 69.8% in non-organophosphate groups). The circumstances of poisoning were mostly suicidal (95.8% in organophosphate groups, 90.5% in non-organophosphate groups) and the reasons for this being mostly family disputes. Organophosphate groups had 8.41 times higher odds of having complications when compared to non-organophosphorus compounds.   Conclusions  The majority of the poisoning cases were suicidal in nature and family disputes being the major reason for the intake of a poisonous substance. This demands that more attention be given to psychological and family counseling to resolve any disputes, as well as psychological management of poisoning cases after medical management. Also, a strong regulatory mechanism should be imposed to control the easy access to poisonous substances.