RESUMO
Non-immune hydrops fetalis represents the end-stage status of a variety of diseases, including metastatic tumors. We report a case of non-immune hydrops fetalis associated with multiple disseminated echogenic nodular lesions detected by ultrasound and confirmed by magnetic resonance. Cordocentesis demonstrated anemia and thrombopenia. Differential diagnosis included histiocytosis X, acute leukemia or metastatic disease. A stillbirth was diagnosed at week 25 + 6. The autopsy revealed hydrops fetalis, a right adrenal gland mass, multiple disseminated nodules histologically composed of small round blue cells positive for synaptophysin, and placental involvement, concordant findings with congenital undifferentiated neuroblastoma Stage M. No chromosomal abnormalities were associated, nor amplification abnormalities in MYCN and ALK genes. Metastatic neuroblastoma should be considered in the differential diagnosis of non-immune hydrops fetalis associated with multiple nodular lesions.
Assuntos
Hidropisia Fetal , Neuroblastoma , Humanos , Feminino , Gravidez , Neoplasias das Glândulas Suprarrenais , Adulto , Complicações Neoplásicas na Gravidez/patologia , Placenta/patologiaRESUMO
En la actualidad, la inyección de materiales en el subcutáneo con fin estético es frecuente. Comunicamos el caso de una paciente con lesiones esclerodermiformesen ambas regiones pretibiales, en cuyo estudio histopatológico se observó un granuloma por silicona. Años atrás la paciente se había sometido ala inyección de un material de relleno en la región glútea. Se trata, por tanto, de un granuloma de cuerpo extraño por silicona que ha migrado a distanciadel lugar de la inoculación. El diagnóstico de este cuadro puede ser difícil. El tratamiento es complicado y, en general, no satisfactorio
Nowadays inoculation of materials for soft tissues augmentation is common. We report the case of a woman with sclerodermiform lessions in pretibialregions, characterized by a silicone granuloma. The histopathologic study in some years ago, she have seen inoculated of an unknown material in glutealregion. This case is a foreing body granuloma caused by silicone migrated from the inoculation site. Diagnosis of this conditions disease may bedifficult, and treatment is often unsatisfactory
Assuntos
Humanos , Feminino , Pessoa de Meia-Idade , Granuloma/etiologia , Silicones/efeitos adversos , Migração de Corpo Estranho/complicações , Falha de PróteseRESUMO
El granuloma elastolítico anular de células gigantes (GEACG) es una entidad poco frecuente, caracterizada clínicamente por placas eritematosas anulares de centro atrófico e hipopigmentado, que predominan en zonas fotoexpuestas. En la histología presentan un infiltrado granulomatoso sin formación de imagen en empalizada, compuesto por linfocitos, histiocitos y células gigantes, con fagocitosis de fibras elásticas, sin necrobiosis ni depósito de mucina. Presentamos el caso de un paciente con manifestaciones clínicas atípicas en piel no fotoexpuesta, y una histología característica de GEACG
Annular elastolytic giant cell granuloma (AEGCG) is an uncommon entity clinically characterized by erythematous annular plaques with atrophic and hypopigmented center, that predominates in sun-exposed zones. The histology shows a granulomatous infiltrate without palisading image, made up of lymphocytes, histiocytes and giant cells, with phagocytosis of elastic fibers, without necrobiosis or mucin deposit. We present the case of a male patient with atypical clinical manifestation on the non-sun exposed skin and AEGCG characteristic histology