RESUMO
Ocimum sanctum fixed oil produced hypotensive effect in anaesthetised dog, which seems to be due to its peripheral vasodilatory action. The oil increased blood-clotting time and percentage increase was comparable to aspirin and could be due to inhibition of platelet aggregation. The oil also increased pentobarbitone-induced sleeping time in rats indicating probable inhibitory effect of oil towards cytochromic enzyme responsible for hepatic metabolism of pentobarbitone.
Assuntos
Antibacterianos/farmacologia , Coagulação Sanguínea/efeitos dos fármacos , Pressão Sanguínea/efeitos dos fármacos , Óleos de Plantas/farmacologia , Sono/efeitos dos fármacos , Animais , Anti-Inflamatórios não Esteroides/farmacologia , Anti-Hipertensivos/farmacologia , Aspirina/farmacologia , Cães , Relação Dose-Resposta a Droga , Hipnóticos e Sedativos/farmacologia , Masculino , Camundongos , Pentobarbital/farmacologia , Ratos , Ratos WistarRESUMO
The capacity of stem cells of peritonium of mesodermal origin to undergo metaplastic transformation and form different tissues developed from mesoderm germ layer is exploited with ulterior motive to use it in the management of human diseases. The excised fallopian tube was replaced with a tube on a stent constructed from autogenous peritoneum from a suitable donor site. The effect of the surroundings environment of the new tissue system to which the peritoneum stem cells are now exposed was studied for 3, 6 and 12 months period in live animal models. The gross and histological studies revealed development of all the component of the wall of the fallopian tube. The lumen of the constructed peritoneal tube was well preserved in its whole length including the anastomotic sites. The scientific rationale of the working hypothesis on which the work is based, is discussed.
Assuntos
Tubas Uterinas/fisiologia , Tubas Uterinas/cirurgia , Regeneração/fisiologia , Anastomose Cirúrgica , Animais , Cães , Tubas Uterinas/citologia , Feminino , Humanos , Mesoderma/citologia , Metaplasia , Peritônio/citologia , Peritônio/transplante , Transplante de Células-Tronco , Células-Tronco/citologia , Transplante AutólogoRESUMO
The fixed oil of Ocimum sanctum (Labiatae) was found to possess significant anti-inflammatory activity against carrageenan- and different other mediator-induced paw edema in rats. Significant inhibitory effect was also observed in castor oil-induced diarrhoea in rats. It also inhibited arachidonic acid and leukotriene-induced paw edema. The results of anti-inflammatory activity of Ocimum sanctum support the dual inhibition of arachidonate metabolism as indicated by its activity in inflammation models that are insensitive to selective cyclooxygenase inhibitors. On the basis of the findings it may be inferred that Ocimum sanctum may be a useful anti-inflammatory agent which blocks both the pathways, i.e. cyclooxygenase and lipoxygenase, or arachidonic acid metabolism.
Assuntos
Anti-Inflamatórios/farmacologia , Ácido Araquidônico/metabolismo , Inibidores de Ciclo-Oxigenase/farmacologia , Inibidores de Lipoxigenase/farmacologia , Óleos de Plantas/farmacologia , Adrenalectomia , Animais , Anti-Inflamatórios/administração & dosagem , Anti-Inflamatórios/uso terapêutico , Ácido Araquidônico/toxicidade , Inibidores de Ciclo-Oxigenase/administração & dosagem , Inibidores de Ciclo-Oxigenase/uso terapêutico , Diarreia/tratamento farmacológico , Modelos Animais de Doenças , Edema/tratamento farmacológico , Leucotrienos/toxicidade , Inibidores de Lipoxigenase/administração & dosagem , Inibidores de Lipoxigenase/uso terapêutico , Óleos de Plantas/administração & dosagem , Óleos de Plantas/uso terapêutico , Ratos , Ratos WistarRESUMO
Regeneration of ureter in vivo is possible from peritoneal stem cells as both are derivative of embryonal germ layer mesoderm. The peritoneal stem cells are engaged in repair of loss due to normal wear and tear by differentiation and proliferation. With pluripotent nature, they have a capacity to undergo metaplastic transformation to various mesodermal tissues. The intrinsic cell factor along with regional tissue organisers coupled with functional need of the region, a desired metaplastic transformation to ureteric wall components is possible.
