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1.
Rev. chil. neuro-psiquiatr ; 57(2): 129-138, jun. 2019. tab, graf
Artigo em Espanhol | LILACS | ID: biblio-1042682

RESUMO

Resumen La vejez se ha caracterizado por la existencia de una declinación natural de la memoria, como asimismo de su autoeficacia. La relación entre ambas ha sido objeto de varias investigaciones que confirman que la autoeficacia de la memoria afecta el rendimiento en tareas de memoria. Sin embargo, existe un grupo menor de investigaciones donde no se presenta dicha relación. El objetivo del estudio fue comparar la percepción de autoeficacia de la memoria con el rendimiento en tareas de memoria en adultos mayores y jóvenes. Los participantes fueron 200 adultos mayores y 111 jóvenes universitarios quienes respondieron dos instrumentos: uno de percepción de autoeficacia de memoria, y otro de rendimiento en tareas memoria operativa y/o memoria de corto plazo, ambos instrumentos fueron construidos y adaptados de forma tal que fueran comparables entre sí. Los resultados muestran que los adultos mayores presentan un menor rendimiento en casi todas las tareas de memoria y una leve superioridad en la percepción de autoeficacia de la memoria, existe una relación significativa entre ambas medicinas. En cambio, en los jóvenes su percepción de autoeficacia fue levemente inferior, pero su rendimiento fue superior.


Aging has been characterized by a natural decline of memory, as well as by a decline in the perception of memory self-efficacy. The relationship between these two variables has been the subject of several studies, confirming that the perception of mnemonic self-efficacy affects actual performance on memory tasks. However, there is a smaller group of studies where this relationship has not been found. The objective of the present study was to compare the perception of self-efficacy of memory with performance in memory tasks in older and younger adults. Two hundred older adults and 111 university students participated in the study by responding two instruments: one Perception of Memory Self-Efficacy, and another one on Performance in Operational Memory tasks. Both instruments were constructed and adapted so that they be comparable. The results showed that older adults have a lower performance in almost all memory tasks and a slight superiority in the perception of memory self-efficacy, and a significant relationship was found between the two. On the other hand, in younger people's beliefs about their memory were slightly lower, but they performed better.


Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Pessoa de Meia-Idade , Idoso , Percepção , Estudantes , Envelhecimento , Autoeficácia , Memória de Curto Prazo
2.
Mol Biol Rep ; 46(1): 1349-1356, 2019 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-30554313

RESUMO

In this work we investigated the possible cellular changes induced by C-phycocyanin (C-PC) in erythroleukemic cells with (K562-Lucena and FEPS) and without (K562) the multidrug resistance (MDR) phenotype. The reactive oxygen levels (ROS) (evaluated by fluorimetry) were increased relative to the control in K562 and K562-Lucena cells treated with 100 µg/mL and were not increased in FEPS cells. The expression of the following genes related to resistance was evaluated by real-time PCR: COX2, ALOX5, ABCB1 and ABCC1. Treatment with 100 µg/mL of C-PC increased COX2 and ABCB1 expression in K562-Lucena cells and reduced expression of ALOX5 in K562-Lucena and FEPS cells. ROS levels appear to be involved in biological responses to C-PC in K562 and K562-Lucena cells, although expression of the genes studied here was only modified by C-PC in the K562-Lucena cell line. Thus, it is possible to suggest that C-PC modulates the expression of COX2 and ABCB1 for the K562-Lucena in a ROS-dependent manner and the expression of ALOX5 for the FEPS in a ROS-independent manner; however, more studies are needed to elucidate these mechanisms.


Assuntos
Resistencia a Medicamentos Antineoplásicos/genética , Regulação Neoplásica da Expressão Gênica/efeitos dos fármacos , Ficocianina/farmacologia , Espécies Reativas de Oxigênio/metabolismo , Apoptose/efeitos dos fármacos , Apoptose/efeitos da radiação , Linhagem Celular Tumoral , Resistencia a Medicamentos Antineoplásicos/efeitos dos fármacos , Humanos , Necrose
3.
Rev. chil. neuro-psiquiatr ; 56(4): 241-250, 2018. tab, graf
Artigo em Espanhol | LILACS | ID: biblio-990863

RESUMO

Resumen La vejez se ha caracterizado por la existencia de una declinación natural de la memoria, como asimismo de su autoeficacia. La relación entre ambas ha sido objeto de varias investigaciones que confirman que la autoeficacia de la memoria afecta el rendimiento en tareas de memoria. Sin embargo, existe un grupo menor de investigaciones donde no se presenta dicha relación. El objetivo del estudio fue comparar la percepción de autoeficacia de la memoria con el rendimiento en tareas de memoria en adultos mayores y jóvenes. Los participantes fueron 200 adultos mayores y 111 jóvenes universitarios quienes respondieron dos instrumentos: uno de percepción de autoeficacia de memoria, y otro de rendimiento en tareas memoria operativa y/o memoria de corto plazo, ambos instrumentos fueron construidos y adaptados de forma tal que fueran comparables entre sí. Los resultados muestran que los adultos mayores presentan un menor rendimiento en casi todas las tareas de memoria y una leve superioridad en la percepción de autoeficacia de la memoria, existe una relación significativa entre ambas medicines. En cambio, en los jóvenes su percepción de autoeficacia fue levemente inferior, pero su rendimiento fue superior.


Aging has been characterized by a natural decline of memory, as well as by a decline in the perception of memory self-efficacy. The relationship between these two variables has been the subject of several studies, confirming that the perception of mnemonic self-efficacy affects actual performance on memory tasks. However, there is a smaller group of studies where this relationship has not been found. The objective of the present study was to compare the perception of self-efficacy of memory with performance in memory tasks in older and younger adults. Two hundred older adults and 111 university students participated in the study by responding two instruments: one Perception of Memory Self-Efficacy, and another one on Performance in Operational Memory tasks. Both instruments were constructed and adapted so that they be comparable. The results showed that older adults have a lower performance in almost all memory tasks and a slight superiority in the perception of memory self-efficacy, and a significant relationship was found between the two. On the other hand, in younger people's beliefs about their memory were slightly lower, but they performed better.


Assuntos
Humanos , Masculino , Feminino , Adolescente , Adulto , Pessoa de Meia-Idade , Idoso , Adulto Jovem , Percepção/fisiologia , Autoeficácia , Memória de Curto Prazo/fisiologia , Fatores Etários
4.
Nervenarzt ; 84(5): 569-75, 2013 May.
Artigo em Alemão | MEDLINE | ID: mdl-23549839

RESUMO

The use of interactive screen media is widespread and for some users leads to pathological symptoms that are phenomenologically similar to signs of addictive disorders. Addictive use of computer games and other Internet applications, such as social media can be distinguished. In the past standard criteria to classify this new disorder were lacking. In DSM-5, nine criteria are proposed for diagnosing Internet gaming disorder. The focus is currently on video games as most studies have been done in this field. Prevalence estimations are difficult to interpret due to the lack of standard diagnostic measures and result in a range of the frequency of Internet addiction between 1 % and 4.2 % in the general German population. Rates are higher in younger individuals. For computer game addiction prevalence rates between 0.9 % and 1.7  % can be found in adolescents. Despite substantial comorbidity among those affected current research points to addictive media use as a stand-alone disorder.


Assuntos
Comportamento Aditivo/epidemiologia , Comportamento Aditivo/psicologia , Transtornos Disruptivos, de Controle do Impulso e da Conduta/epidemiologia , Transtornos Disruptivos, de Controle do Impulso e da Conduta/psicologia , Internet/estatística & dados numéricos , Jogos de Vídeo/psicologia , Adolescente , Medicina Baseada em Evidências , Humanos , Modelos Psicológicos , Prevalência , Jogos de Vídeo/estatística & dados numéricos , Adulto Jovem
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