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1.
Rev Sci Instrum ; 79(10): 10E915, 2008 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-19044570

RESUMO

We have successfully demonstrated a 7.5 ns duration pinhole-apertured backlighter at the Omega laser facility. Pinhole-apertured point-projection backlighting for 8 ns will be useful for imaging evolving features in experiments at the National Ignition Facility. The backlighter consisted of a 20 microm diameter pinhole in a 75 microm thick Ta substrate separated from a Zn emitter (9 keV) by a 400 microm thick high-density carbon piece. The carbon prevented the shock from the laser-driven surface from reaching the substrate before 8 ns and helped minimize x-ray ablation of the pinhole substrate. Grid wires in x-ray framing camera images of a gold grid have a source-limited resolution significantly smaller than the pinhole diameter due to the high aspect ratio of the pinhole, but do not become much smaller at late times.

2.
Phys Rev Lett ; 101(3): 035001, 2008 Jul 18.
Artigo em Inglês | MEDLINE | ID: mdl-18764258

RESUMO

Experiments have been conducted using laser-driven cylindrical hohlraums whose walls are machined from Ta2O5 foams of 100 mg/cc and 4 g/cc densities. Measurements of the radiation temperature demonstrate that the lower density walls produce higher radiation temperatures than the high density walls. This is the first experimental demonstration of the prediction that this would occur [M. D. Rosen and J. H. Hammer, Phys. Rev. E 72, 056403 (2005)10.1103/PhysRevE.72.056403]. For high density walls, the radiation front propagates subsonically, and part of the absorbed energy is wasted by the flow kinetic energy. For the lower wall density, the front velocity is supersonic and can devote almost all of the absorbed energy to heating the wall.

3.
Brain Behav Immun ; 20(3): 201-9, 2006 May.
Artigo em Inglês | MEDLINE | ID: mdl-16504463

RESUMO

Increased serum levels of inflammatory mediators have been associated with numerous disease states including atherosclerosis, Type II diabetes, hypertension, depression, and overall mortality. We hypothesized that a long-term exercise intervention among older adults would reduce serum inflammatory cytokines, and this reduction would be mediated, in part, by improvements in psychosocial factors and/or by beta-adrenergic receptor mechanisms. Adults age 64 were randomly assigned to either an aerobic exercise treatment (CARDIO) or a flexibility/strength exercise treatment (FLEX) 3 days/week, 45 min/day for 10 months. A subgroup of subjects treated with non-selective beta(1)beta(2) adrenergic antagonists were included to evaluate the potential role of beta-adrenergic receptor adaptations as mediators of an exercise-induced change in inflammation. The inflammatory mediators [C-reactive protein (CRP), IL-6, tumor necrosis factor (TNF)-alpha, and IL-18] and the psychosocial factors (depression, perceived stress, optimism, sense of coherence, and social support) were measured pre- and post-intervention. The CARDIO treatment resulted in significant reductions in serum CRP, IL-6, and IL-18 compared to the FLEX treatment (significant treatment x time interaction, p<.05), whereas TNFalpha declined in both groups (main effect of time, p=.001). However, several psychosocial factors (depression, optimism, and sense of coherence) improved in both groups suggesting that the reduction of CRP, IL-6, and IL-18 in the CARDIO group was not mediated by improvements in psychosocial scores. With respect to the potential role of beta-adrenergic receptors, both CARDIO subjects treated with beta-adrenergic antagonists and those who were not treated with those medications demonstrated similar reductions in serum CRP, IL-6, IL-18, and TNFalpha. In summary, we have observed that an aerobic exercise intervention can significantly reduce serum inflammatory mediators, but beta-adrenergic receptors and psychosocial factors do not appear to be involved.


Assuntos
Idoso/fisiologia , Exercício Físico/fisiologia , Exercício Físico/psicologia , Mediadores da Inflamação/sangue , Inflamação/sangue , Adaptação Fisiológica/efeitos dos fármacos , Antagonistas Adrenérgicos beta/farmacologia , Idoso/psicologia , Índice de Massa Corporal , Proteína C-Reativa/análise , Feminino , Humanos , Inflamação/psicologia , Interleucina-18/sangue , Interleucina-6/sangue , Masculino , Esforço Físico/fisiologia , Maleabilidade , Psicologia , Valores de Referência , Fator de Necrose Tumoral alfa/análise
4.
Phys Rev Lett ; 86(13): 2794-7, 2001 Mar 26.
Artigo em Inglês | MEDLINE | ID: mdl-11290041

RESUMO

We report the first measurement of a reduction in the conductivity of liquid sodium due to turbulence in a spherical flow (the beta effect). The sodium is contained in a 0.15 m diameter sphere, typical flow speeds are about 1 m/s, and magnetic Reynold's numbers range from 1 to 8. We find a reduction from the molecular value of the conductivity of about 4%. Results are in rough agreement with simple predictions from mean-field electrodynamics.

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