Metástasis intracanalicular de la vía biliar por carcinoma colorrectal como causa de ictericia obstructiva / Intracanalicular metastasis of biliary tract from colorectal carcinoma as cause of obstructive jaundice

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[Non-immunoallergic hepatotoxicity due to mesalazine]. / Hepatotoxicidad no inmunoalérgica por mesalazina.

Mesalazine is an aminosalicillic derivative considered as a safe alternative to the relative frequency (5-55%) of adverse effects observed with sulfasalazine. The well known hepatoxicity associated with sulfasalazine and attributed to its sulfamidic fraction is limited to few cases described in the treatment with mesalazine. We herein present a new case of hepatoxicity by mesalazine in a patient with lymphocytic colitis. The possible pathogenic mechanism is also commented upon.