Return to work after sickness absence: a register-based comparison of two indigenous population groups.

OBJECTIVES: The objective of the article was to analyse how Finnish and Swedish speakers in Finland differ in health and labour market outcomes after sickness absence. Apart from many similarities, these two population groups differ in life expectancy and union stability and are supposed to be culturally distinct. Our analyses, therefore, help to shed light on the interrelation between culture and health. STUDY DESIGN: We monitored health and labour market-related status 3 years after the first sickness absence. METHODS: The register-based longitudinal data covered the years 1988-2010. Multinomial logistic regressions were used to quantify the odds of being unemployed, retired due to disability, otherwise outside the labour force or dead, as compared with being employed. The analyses were controlled for age, educational level, region of residence, population density, birth region, family status, job industry, income, homeownership, time period and time on sick leave. RESULTS: Unemployment after sickness absence was notably more common for Finnish speakers than for Swedish speakers. In the fully adjusted models, the odds ratios were 1.48 (95% confidence interval [CI] 1.23-1.67) in men and 1.29 (95% CI 1.07-1.48) in women. Disability pension, being outside the labour force and having died were also more frequent outcomes for Finnish speakers than for Swedish speakers, although most of this variation could be attributed to socio-economic and demographic characteristics. CONCLUSIONS: The article illustrates that register-based analyses can be effective tools for assessing and identifying persons with latent problems that impede their functioning in the labour market. These findings also suggest that culturally related factors presumably play an important role in this concern.

BRCT domain-containing protein TopBP1 functions in DNA replication and damage response.

Topoisomerase IIbeta-binding protein (TopBP1), a human protein with eight BRCT domains, is similar to Saccharomyces cerevisiae Dpb11 and Schizosaccharomyces pombe Cut5 checkpoint proteins and closely related to Drosophila Mus101. We show that human TopBP1 is required for DNA replication and that it interacts with DNA polymerase epsilon. In S phase TopBP1 colocalizes with Brca1 to foci that do not represent sites of ongoing DNA replication. Inhibition of DNA synthesis leads to relocalization of TopBP1 together with Brca1 to replication forks, suggesting a role in rescue of stalled forks. DNA damage induces formation of distinct TopBP1 foci that colocalize with Brca1 in S phase, but not in G(1) phase. We also show that TopBP1 interacts with the checkpoint protein hRad9. Thus, these results implicate TopBP1 in replication and checkpoint functions.