Use of tetracycline and niacinamide for treatment of autoimmune skin disease in 31 dogs.

A combination of niacinamide and tetracycline was used to treat 31 dogs with various autoimmune skin diseases (discoid lupus erythematosus, pemphigus foliaceus, pemphigus erythematosus, and bullous pemphigoid). Of the 20 dogs with discoid lupus erythematosus, 70% had excellent or good response to treatment. Serious side effects were not noticed in any dog.

The clinical approach to the pruritic dog.

Diagnosis of pruritic skin disease can be a time-consuming process. Careful attention must be paid to history, clinical examination, laboratory and clinical testing, methodical elimination of the differential diagnoses, and client communication in order to achieve success.

Dermatosis associated with feeding generic dog food: 13 cases (1981-1982).

The records of 13 dogs with a crusting dermatosis of the mucocutaneous junctions, pressure points, and trunk were evaluated. All of the dogs had been fed corn- and wheat-based commercial dry dog foods that failed to meet the National Research Council's recommendations for balanced nutrition. The dermatosis in all 13 dogs resolved completely after the diet was changed to one that met the National Research Council's recommendations. The disease was similar to that which has previously been called canine dry pyoderma, but is now known to be a zinc-responsive dermatosis.

Histopathologic features of pyotraumatic dermatitis.

The skin of 17 dogs with pyotraumatic dermatitis was studied microscopically. Two patterns were seen. The first pattern was a superficial, ulcerative, inflammatory process of undetermined cause and pathogenesis. Current recommended treatment, which includes corticosteroids, was believed to be appropriate for such lesions. The second pattern, suppurative folliculitis, was considered to be localized pyoderma. Dogs with severe folliculitis were believed to represent those cases of pyotraumatic dermatitis in which the response to corticosteroid treatment has been poor. It was concluded that antibiotics should be used for treating pyotraumatic dermatitis with suppurative folliculitis, in lesions responding poorly to treatment with corticosteroids, or possibly in any severe lesion of pyotraumatic dermatitis, especially in Golden Retrievers and Saint Bernards.

Actinomycotic mycetoma in a cat.

Actinomycotic mycetoma, a chronic, progressive infection of the subcutaneous tissue characterized by tumefaction, draining sinuses, and grains, was diagnosed in the right hindlimb of a young adult, male cat. The organisms that cause actinomycetoma are soil or plant saprophytes that gain entrance to the skin through abrasion or traumatic implantation. Streptomyces griseus, an organism generally considered to be a saprophyte, was cultured bacteriologically. Despite extensive surgery and long-term antibiotic therapy, the infection persisted, and the cat was euthanatized.

Cutaneous atypical mycobacteriosis in cats.

Cutaneous infection with atypical mycobacteria was observed in 6 cats. All cats had cutaneous or subcutaneous masses, with or without fistulous tracts. Diagnosis was determined by microbial culture. Transmission studies were done in 1 case. Treatment, which included antibiotics or surgery, or both, was usually unsuccessful, but remission without treatment did occur. In 3 cats available for long-term evaluation, there has been no recurrence of disease.