[Specificity and mechanism of serotonin stimulation of adenylate deaminase activity]. / O spetsifichnosti i mekhanizme stimuliatsii serotoninom adenilatdezaminaznoi aktivnosti

Adenylate deaminating activity was stimulated in the liver mitochondria of rats in vivo not only by serotonin or synthetic indolylalkylamines, but also by phenyl- and imidazolalkyamines. Actinomycin D and cycloheximide protein biosynthesis inhibitors prevented stimulation of adenylate deaminating activity. Theophylline, phosphodiesterase inhibitor, produced a similar effect only when the extent of stimulation of adenylate deaminating activity was comparatively high.