RESUMO
Morphological variation of the Y chromosome has been observed in different populations. This variation is mostly related to the heteromorphic Yq12 band, which is composed of a variable block of constitutive heterochromatin. The Yqh+ heteromorphism has a worldwide frequency of 2.85% and is considered clinically innocuous. The aim of this study was to identify the ancestry of the Yqh+ heteromorphism present in individuals from western Mexico. For this purpose, 17 Y-chromosome single nucleotide polymorphisms were analysed by multiplex polymerase chain reaction and SNaPshot assays. In 28 Yqh+ males, only five haplogroups were observed; with a haplogroup diversity of 0.4841 ± 0.1094, which was less than that observed in a study of unselected Mexican mestizo population. Differences were specifically conferred by the high frequencies of haplogroups R1b1 and P*(xQ,R), and by the absence of the Amerindian haplogroup Q (Q*(xQ1a3a) plus Q1a3a) from the Yqh+ group. This study suggests a post-1492 incorporation for Yqh+ chromosomes into the Mexican northwestern population.
Assuntos
Cromossomos Humanos Y/genética , Genética Populacional/métodos , Haplótipos/genética , Polimorfismo de Nucleotídeo Único , Frequência do Gene , Geografia , Humanos , Cariótipo , Masculino , MéxicoAssuntos
Linfócitos B/imunologia , Aberrações Cromossômicas , Linfocitose/genética , Linfocitose/imunologia , Idoso , Idoso de 80 Anos ou mais , Células da Medula Óssea/patologia , Antígenos CD5/metabolismo , Cromossomos Humanos Par 14/genética , Cromossomos Humanos Par 6/genética , Feminino , Humanos , Cariotipagem , Translocação GenéticaRESUMO
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