RESUMO
RESUMO A partir do desastre socioambiental ocorrido em Mariana (MG), em 5 de novembro de 2015, o estudo buscou compreender a atividade dos técnicos da Defesa Civil que atuaram no desastre. A reflexão que aqui se desenvolve parte do esforço de dar visibilidade à atividade desses profissionais que atuam em condições permeadas de imprevisibilidades e pressões. O estudo tem como referenciais os aportes do campo da Saúde do Trabalhador e da ergologia. Trata-se de uma pesquisa empírica, de abordagem qualitativa, realizada por meio de observação direta e entrevistas individuais semiestruturadas com trabalhadores da Defesa Civil. A análise dos resultados foi organizada em duas grandes seções com os seus respectivos desdobramentos: a primeira traz uma contextualização do desastre narrada pelos diversificados profissionais que atuaram; a segunda evidencia desafios e perspectivas que os agentes de defesa civil puderam tirar da catástrofe. Diante da complexidade das situações e da dimensão imprevisível do risco, os agentes de defesa civil são constantemente convocados a 'renormatizar' e a operar escolhas a partir de sua história e de seus valores para lidar com as infidelidades do meio.
ABSTRACT From the socio-environmental disaster that took place on November 5th, 2015 in Mariana (MG), the study sought to understand the activity of Civil Defense technicians who acted in the disaster, aiming to collaborate for actions of worker's health surveillance. The reflection that develops here is part of the effort to give visibility to the activity of those professionals who work in conditions permeated with unpredictability and pressure. The study has as references the contributions from the field of Occupational Health and ergology. This is an empirical research with a qualitative approach, conducted through direct observation and semi-structured individual interviews with Civil Defense professionals. The analysis of the results was organized in two large sections with their respective consequences: the first brings a contextualization of the disaster narrated by the several professionals who worked during it; the second focuses on the challenges and perspectives that civil defense agents have been able to draw from the disaster. Faced with the complexity of situations and the unpredictable dimension of risk, civil defense agents are constantly called upon to 'renormatize' and operate choices based on their history and their values to deal with environmental infidelities.
RESUMO
BACKGROUND: Rotator cuff disease (RCD) is a complex process influenced by a multitude of factors, and a number of gene pathways are altered in rotator cuff tears. Polymorphisms in these genes can lead to an extended tendon degeneration process, which explains why subsets of patients are more susceptible to RCD. MATERIALS AND METHODS: Twenty-three single-nucleotide polymorphisms within 6 genes involved in repair and degenerative processes (DEFB1, DENND2C, ESRRB, FGF3, FGF10, and FGFR1) were investigated in 410 patients, 203 with a diagnosis of RCD and 207 presenting with absence of RCD. Exclusion criteria were patients older than 60 years and younger than 45 years with a history of trauma, rheumatoid arthritis, autoimmune syndrome, pregnancy, and use of corticosteroids. Genomic DNA was obtained from saliva samples. Genetic markers were genotyped with TaqMan real-time polymerase chain reaction. The χ(2) test compared genotypes and haplotype differences between groups. Multivariate logistic regression analyzed the significance of many covariates and the incidence of RCD. RESULTS: Statistical analysis revealed female sex (P = .001; odds ratio, 2.07 [1.30-3.30]) and being white (P = .002; odds ratio, 1.88 [1.21-2.90]) to be risk factors for RCD development. A significant association of haplotypes CCTTCCAG in ESRRB (P = .05), CGACG in FGF3 (P = .01), CC in DEFB1 (P = .03), and FGFR1 rs13317 (P = .02) with RCD could be observed. Also, association between FGF10 rs11750845 (P = .03) and rs1011814 (P = .01) was observed after adjustment by ethnic group and sex. CONCLUSIONS: Our work clearly supports the role of DEFB1, ESRRB, FGF3, FGF10, and FGFR1 genes in RCD. Identification of these variants can clarify causal pathways and provide a clue for therapeutic targets.